Development Level

Tchem 13 | 1,598
Tclin 11 | 613
Tbio 10 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased vertical activity 2 | 208
increased blood urea nitrogen ... 2 | 48
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
hyperactivity 1 | 148
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 26 | 11,493
osteosarcoma 22 | 7,950
ovarian cancer 20 | 8,520
Cancer 17 | 2,499
lung cancer 17 | 4,740
psoriasis 15 | 6,694
medulloblastoma, large-cell 14 | 6,241
diabetes mellitus 12 | 1,728
atypical teratoid / rhabdoid tumor 11 | 5,112
glioblastoma 11 | 5,792
group 3 medulloblastoma 11 | 4,104
interstitial cystitis 11 | 2,312
Neurodegenerative disease 10 | 414
ependymoma 10 | 4,679
lung carcinoma 10 | 2,843
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 9 | 3,578
Autosomal recessive predisposition 8 | 1,442
Blastic phase chronic myeloid leukemia 8 | 58
Chronic Myelocytic Leukemia Accelerated Phase 8 | 59
Parkinson's disease 8 | 392
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
subependymal giant cell astrocytoma 8 | 2,287
Alzheimer's disease 7 | 658
Bipolar Disorder 7 | 666
Dystonia 7 | 164
Parkinsonian Disorders 7 | 56
Pick disease 7 | 1,894
Toxic encephalopathy 7 | 141
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
pancreatic cancer 7 | 2,398
ulcerative colitis 7 | 1,819
Alcoholic Intoxication, Chronic 6 | 289
Brain disease 6 | 96
Chronic phase chronic myeloid leukemia 6 | 45
Depressive disorder 6 | 409
Multiple system atrophy 6 | 29
Muscle Rigidity 6 | 49
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 6 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 6 | 47
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 3,801
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
tuberculosis 6 | 2,010
Bradykinesia 5 | 34
Dementia 5 | 175
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Major Depressive Disorder 5 | 301
Melanoma 5 | 711
Nerve Degeneration 5 | 121
Parkinson Disease 5 | 64
Progressive disorder 5 | 142
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
pediatric high grade glioma 5 | 1,064
primitive neuroectodermal tumor 5 | 3,035
Atopic dermatitis 4 | 952
Attention deficit hyperactivity disorder 4 | 278
Chronic Lymphocytic Leukemia 4 | 262
Dysarthria 4 | 192
Heart disease 4 | 306
Infantile onset 4 | 238
Kidney cancer 4 | 2,613
Mood Disorders 4 | 184
Multiple myeloma 4 | 1,332
PARKINSON DISEASE 19, JUVENILE-ONSET 4 | 10
PARKINSON DISEASE, LATE-ONSET 4 | 20
Tremor 4 | 113
Unipolar Depression 4 | 250
Young onset Parkinson disease 4 | 10
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
non primary Sjogren syndrome sicca 4 | 891
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676
Arthritis 3 | 290
Carcinoma, Hepatocellular 3 | 228
Colonic Neoplasms 3 | 142
Crohn's disease 3 | 321
Hypertension 3 | 396
Liver carcinoma 3 | 240
Mental Depression 3 | 333
Vascular disease 3 | 319
aldosterone-producing adenoma 3 | 665
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972

Tissue

Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 31 | 15,192
Respiratory system 31 | 16,393

Target Family

Kinase 13 | 634
Enzyme 12 | 4,145
Non-IDG 8 | 12,091
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Sodium-dependent dopamine transporter SLC6A3 Tclin Transporter -3.59848 3752.4 324
Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Tbio Non-IDG -1.74801 58.4 325
Ubiquitin carboxyl-terminal hydrolase isozyme L1 UCHL1 Tchem Enzyme -3.16318 1414.2 1378
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804
Tyrosine-protein kinase Fgr FGR Tchem Kinase -2.37977 226.9 400