Development Level

Tbio 19 | 11,445
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cataract 1 | 92
cornea ulcer 1 | 1
corneal opacity 1 | 32
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
fused cornea and lens 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
iris synechia 1 | 3
narrow eye opening 1 | 12
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 23 | 11,493
ovarian cancer 23 | 8,520
Cancer 22 | 2,499
group 3 medulloblastoma 20 | 4,104
lung cancer 20 | 4,740
osteosarcoma 19 | 7,950
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
Short stature 14 | 531
Autosomal recessive predisposition 13 | 1,442
Small head 13 | 374
primitive neuroectodermal tumor 13 | 3,035
Breast cancer 12 | 3,578
Dull intelligence 12 | 645
Intellectual disability 12 | 1,016
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
psoriasis 12 | 6,694
Chromosome Breakage 11 | 36
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
non-small cell lung cancer 11 | 2,890
Anemia 10 | 365
Increased chromosomal breakage 10 | 27
Thrombocytopenia 10 | 197
Acquired scoliosis 9 | 281
Ataxia telangiectasia 9 | 34
Cognitive delay 9 | 608
Curvature of spine 9 | 282
Decreased platelet count 9 | 111
Fanconi anemia 9 | 56
Global developmental delay 9 | 608
Kidney cancer 9 | 2,613
Leukopenia 9 | 72
Mental and motor retardation 9 | 608
Nijmegen breakage syndrome 9 | 24
Almond-shaped eyes 8 | 23
Irregular hyperpigmentation 8 | 33
Pyridoxine-responsive sideroblastic anemia 8 | 17
Radial aplasia/hypoplasia 8 | 29
Short palpebral fissure 8 | 38
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
hypopigmented skin patch 8 | 59
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Birthmark 7 | 35
Cafe-au-Lait Spots 7 | 37
Esophageal atresia 7 | 43
Esophageal atresia with or without tracheoesophageal fistula 7 | 21
Fanconi Anemia, Complementation Group a 7 | 9
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Prostatic Neoplasms 7 | 495
Tracheoesophageal Fistula 7 | 36
breast carcinoma 7 | 1,638
colon cancer 7 | 1,478
esophageal atresia/tracheoesophageal fistula 7 | 22
oligodendroglioma 7 | 2,850
Breast Neoplasms 6 | 445
Hematologic Neoplasms 6 | 22
Hemoglobin low 6 | 124
Leukemia 6 | 104
Mammary Neoplasms 6 | 425
Strabismus 6 | 270
acute quadriplegic myopathy 6 | 1,158
dermatomyositis 6 | 966
Abnormally small eyeball 5 | 97
Adenoid Cystic Carcinoma 5 | 99
Astrocytoma, Pilocytic 5 | 3,081
Carcinoma, Adenoid Cystic 5 | 99
Cryptorchidism 5 | 296
Decreased size of eyeball 5 | 97
Low Birth Weights 5 | 69
Microcephaly 5 | 166
Microphthalmos 5 | 100
Neutrophil count decreased 5 | 47
Pancytopenia 5 | 45
Pick disease 5 | 1,894
Small for gestational age (disorder) 5 | 69
Waldenstrons macroglobulinemia 5 | 765
Werner syndrome 5 | 29
Xeroderma pigmentosum 5 | 43
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
lung adenocarcinoma 5 | 2,716
nasopharyngeal carcinoma 5 | 1,058
Allergic hypersensitivity disease 4 | 126
Bladder Neoplasm 4 | 112
Liver cancer 4 | 604
Melanoma 4 | 711
Urinary Bladder Neoplasms 4 | 114
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 29 | 16,909
Cardiovascular System 29 | 15,192
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678

Target Family

Non-IDG 20 | 12,091
Kinase 4 | 634
Enzyme 3 | 4,145
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Fanconi anemia group C protein FANCC Tbio Non-IDG -2.85516 703.4 348
RNA-binding protein EWS EWSR1 Tbio Non-IDG -3.04399 1141.6 411
Fanconi anemia group D2 protein FANCD2 Tbio Non-IDG -2.59123 391.6 404
Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Tbio Non-IDG -1.74801 58.4 325
DNA topoisomerase 2-binding protein 1 TOPBP1 Tbio Enzyme -2.04312 118.0 230
Fanconi anemia group A protein FANCA Tbio Non-IDG -2.37849 237.4 314
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542