Development Level

Tbio 13 | 11,445
Tchem 10 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
female infertility 1 | 60
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Cancer 19 | 2,499
Carcinoma 19 | 11,493
ovarian cancer 16 | 8,520
osteosarcoma 14 | 7,950
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
medulloblastoma, large-cell 12 | 6,241
invasive ductal carcinoma 11 | 2,951
malignant mesothelioma 10 | 3,232
psoriasis 10 | 6,694
Breast cancer 9 | 3,578
atypical teratoid / rhabdoid tumor 9 | 5,112
lung adenocarcinoma 9 | 2,716
group 4 medulloblastoma 8 | 1,855
Multiple myeloma 7 | 1,332
adult high grade glioma 7 | 3,801
breast carcinoma 7 | 1,638
ependymoma 7 | 4,679
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
Schizophrenia 6 | 1,160
astrocytoma 6 | 1,146
ductal carcinoma in situ 6 | 1,745
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
Anemia 5 | 365
Astrocytoma, Pilocytic 5 | 3,081
Kidney cancer 5 | 2,613
Liver Cirrhosis, Experimental 5 | 769
Rheumatoid arthritis 5 | 1,191
astrocytic glioma 5 | 2,597
hepatocellular carcinoma 5 | 547
interstitial cystitis 5 | 2,312
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Crohn's disease 4 | 321
Fatigue 4 | 182
Mammary Neoplasms, Experimental 4 | 154
Waldenstrons macroglobulinemia 4 | 765
cystic fibrosis 4 | 1,696
group 3 medulloblastoma 4 | 4,104
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Adenocarcinoma 3 | 122
Animal Mammary Neoplasms 3 | 136
Arthritis 3 | 290
Breast Neoplasms 3 | 445
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Squamous Cell 3 | 110
Down syndrome 3 | 499
Hypoplastic mandible condyle 3 | 275
Immune system cancer 3 | 140
Leukemia 3 | 104
Liver carcinoma 3 | 240
Lung Neoplasms 3 | 232
Lymphoid leukemia 3 | 160
Mammary Neoplasms 3 | 425
Mammary Neoplasms, Animal 3 | 136
Mandibular hypoplasia 3 | 275
Mastocytosis 3 | 27
Micrognathism 3 | 275
Myocardial Ischemia 3 | 169
Myopia 3 | 176
Neoplasm Metastasis 3 | 168
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Polycythemia vera 3 | 27
Precancerous Conditions 3 | 80
Primary polycythemia 3 | 8
Prostatic Neoplasms 3 | 495
Somatic mutation 3 | 61
Squamous cell carcinoma 3 | 129
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic carcinoma 3 | 562
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Congenital Epicanthus 2 | 177
Curvature of spine 2 | 282
Delayed bone age 2 | 136
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Failure to gain weight 2 | 365
Hepatomegaly 2 | 285
Hypereosinophilic syndrome 2 | 71
Nasal bridge wide 2 | 236
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Ventricular Septal Defects 2 | 119
pediatric high grade glioma 2 | 1,064

Tissue

Endocrine System 27 | 18,159
Male tissues 27 | 17,142
Blood and immune system 26 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Non-IDG 12 | 12,091
Kinase 7 | 634
Transcription Factor 4 | 1,400
Enzyme 3 | 4,145
Epigenetic 1 | 242

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 27 | 27
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
DNA-binding protein inhibitor ID-1 ID1 Tbio Transcription Factor -2.62261 440.3 311
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Signal recognition particle 9 kDa protein SRP9 Tbio Non-IDG -1.52679 31.8 33