Development Level

Tbio 58 | 11,445
Tchem 17 | 1,598
Tclin 4 | 613
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
enlarged heart 5 | 210
preweaning lethality, incomple... 5 | 499
cataract 3 | 92
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
corneal opacity 2 | 32
decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal limb morphology 1 | 13
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality 1 | 28
protruding tongue 1 | 3
small spleen 1 | 19
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 60 | 11,493
ovarian cancer 49 | 8,520
atypical teratoid / rhabdoid tumor 44 | 5,112
psoriasis 44 | 6,694
Cancer 43 | 2,499
lung cancer 43 | 4,740
osteosarcoma 43 | 7,950
glioblastoma 37 | 5,792
medulloblastoma, large-cell 35 | 6,241
ependymoma 31 | 4,679
Breast cancer 30 | 3,578
malignant mesothelioma 24 | 3,232
interstitial cystitis 23 | 2,312
oligodendroglioma 23 | 2,850
primitive neuroectodermal tumor 23 | 3,035
Kidney cancer 22 | 2,613
adult high grade glioma 22 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
invasive ductal carcinoma 22 | 2,951
pancreatic cancer 22 | 2,398
Schizophrenia 21 | 1,160
group 3 medulloblastoma 20 | 4,104
non-small cell lung cancer 20 | 2,890
astrocytic glioma 19 | 2,597
astrocytoma 19 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
lung adenocarcinoma 19 | 2,716
Astrocytoma, Pilocytic 18 | 3,081
cystic fibrosis 18 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
lung carcinoma 18 | 2,843
ulcerative colitis 18 | 1,819
Multiple myeloma 17 | 1,332
breast carcinoma 17 | 1,638
diabetes mellitus 17 | 1,728
subependymal giant cell astrocytoma 17 | 2,287
Breast Neoplasms 16 | 445
acute quadriplegic myopathy 16 | 1,158
Mammary Neoplasms 15 | 425
ductal carcinoma in situ 15 | 1,745
group 4 medulloblastoma 15 | 1,855
colon cancer 14 | 1,478
medulloblastoma 14 | 720
pituitary cancer 14 | 1,972
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Prostatic Neoplasms 13 | 495
Rheumatoid arthritis 13 | 1,191
adrenocortical carcinoma 13 | 1,428
juvenile dermatomyositis 13 | 1,187
Bipolar Disorder 12 | 666
Intellectual disability 12 | 1,016
primary pancreatic ductal adenocarcinoma 12 | 1,109
Lymphoid leukemia 11 | 160
Melanoma 11 | 711
Mental Depression 11 | 333
Pick disease 11 | 1,894
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Carcinoma, Squamous Cell 10 | 110
Colonic Neoplasms 10 | 142
Colorectal Neoplasms 10 | 243
Immune system cancer 10 | 140
Squamous cell carcinoma 10 | 129
esophageal adenocarcinoma 10 | 737
Endometriosis 9 | 540
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
dermatomyositis 9 | 966
tuberculosis 9 | 2,010
Alcoholic Intoxication, Chronic 8 | 289
Cell Transformation, Neoplastic 8 | 97
Cognitive delay 8 | 608
Duchenne muscular dystrophy 8 | 601
Endometrial cancer 8 | 311
Epilepsy 8 | 792
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Neoplasm Metastasis 8 | 168
Neoplastic Cell Transformation 8 | 89
Ovarian Neoplasms 8 | 102
Short stature 8 | 531
Skin cancer 8 | 469
Small head 8 | 374
Strabismus 8 | 270
Vascular disease 8 | 319
gastric carcinoma 8 | 807
ovarian neoplasm 8 | 99
sarcoidosis 8 | 370
Broad flat nasal bridge 7 | 236
Depressive disorder 7 | 409
Muscle hypotonia 7 | 571
Seizures 7 | 596
aldosterone-producing adenoma 7 | 665
chronic lymphosyte leukemia 7 | 204
cutaneous lupus erythematosus 7 | 1,057
nasopharyngeal carcinoma 7 | 1,058
pediatric high grade glioma 7 | 1,064
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074

Tissue

Endocrine System 76 | 18,159
Digestive Tract 75 | 17,369
Skin and soft tissues 74 | 17,230
Blood and immune system 73 | 16,909
Male tissues 73 | 17,142
Female tissues 72 | 17,400
Liver and Pancreas 71 | 16,750
Urinary Tract 70 | 16,678
Nervous System 69 | 16,725
Respiratory system 69 | 16,393
Cardiovascular System 63 | 15,192

Target Family

Non-IDG 41 | 12,091
Transcription Factor 21 | 1,400
Enzyme 8 | 4,145
Epigenetic 5 | 242
Ion Channel 2 | 344
Kinase 2 | 634
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Transcription factor Sp5 SP5 Tdark Transcription Factor 0.30 0.34 21
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G Tclin Ion Channel -2.16668 140.8 217
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
Insulin-like growth factor 2 mRNA-binding protein 1 IGF2BP1 Tbio Non-IDG -1.85997 76.0 207
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.25853 1689.4 685
Mediator of RNA polymerase II transcription subunit 12 MED12 Tbio Enzyme -2.60835 402.9 124
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114