Development Level

Tbio 41 | 11,445
Tchem 16 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged spleen 2 | 41
increased circulating HDL chol... 2 | 80
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal eating behavior 1 | 1
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart atrium 1 | 4
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small seminal vesicle 1 | 10
small spleen 1 | 19
small testis 1 | 58
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 46 | 11,493
Cancer 40 | 2,499
glioblastoma 38 | 5,792
medulloblastoma, large-cell 38 | 6,241
ovarian cancer 35 | 8,520
atypical teratoid / rhabdoid tumor 33 | 5,112
psoriasis 33 | 6,694
osteosarcoma 31 | 7,950
lung cancer 26 | 4,740
ependymoma 24 | 4,679
primitive neuroectodermal tumor 24 | 3,035
adult high grade glioma 21 | 3,801
Astrocytoma, Pilocytic 20 | 3,081
group 3 medulloblastoma 20 | 4,104
oligodendroglioma 20 | 2,850
Breast cancer 19 | 3,578
malignant mesothelioma 18 | 3,232
Kidney cancer 16 | 2,613
astrocytic glioma 15 | 2,597
lung carcinoma 15 | 2,843
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pituitary cancer 14 | 1,972
Alzheimer's disease 13 | 658
Pick disease 13 | 1,894
invasive ductal carcinoma 13 | 2,951
non-small cell lung cancer 13 | 2,890
pediatric high grade glioma 13 | 1,064
Schizophrenia 12 | 1,160
astrocytoma 12 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
pancreatic cancer 12 | 2,398
Multiple myeloma 10 | 1,332
Rheumatoid arthritis 10 | 1,191
juvenile dermatomyositis 10 | 1,187
primary pancreatic ductal adenocarcinoma 10 | 1,109
subependymal giant cell astrocytoma 10 | 2,287
Carcinoma, Squamous Cell 9 | 110
Immune system cancer 9 | 140
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Adenoid Cystic Carcinoma 8 | 99
Carcinoma, Adenoid Cystic 8 | 99
Waldenstrons macroglobulinemia 8 | 765
ductal carcinoma in situ 8 | 1,745
Duchenne muscular dystrophy 7 | 601
Esophageal Squamous Cell Carcinoma 7 | 77
Failure to gain weight 7 | 365
Liver cancer 7 | 604
Lymphoid leukemia 7 | 160
Pediatric failure to thrive 7 | 365
Squamous cell carcinoma of esophagus 7 | 77
acute myeloid leukemia 7 | 783
breast carcinoma 7 | 1,638
diabetes mellitus 7 | 1,728
tuberculosis 7 | 2,010
Bipolar Disorder 6 | 666
Carcinoma, Pancreatic Ductal 6 | 20
Lung Neoplasms 6 | 232
Orbital separation excessive 6 | 244
Short stature 6 | 531
Strabismus 6 | 270
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
colon cancer 6 | 1,478
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
lung adenocarcinoma 6 | 2,716
medulloblastoma 6 | 720
nasopharyngeal carcinoma 6 | 1,058
Acquired scoliosis 5 | 281
Brachydactyly 5 | 156
Cataract 5 | 297
Colonic Neoplasms 5 | 142
Cryptorchidism 5 | 296
Curvature of spine 5 | 282
Downward slant of palpebral fissure 5 | 158
Endometriosis 5 | 540
Fetal Growth Retardation 5 | 189
Hypoplastic mandible condyle 5 | 275
Lens Opacities 5 | 231
Liver carcinoma 5 | 240
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Seizures 5 | 596
Short distal phalanges 5 | 50
Squamous cell carcinoma 5 | 129
Stomach Neoplasms 5 | 300
Uterine Cervical Neoplasm 5 | 25
Uterine Cervical Neoplasms 5 | 26
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Down syndrome 4 | 499
Epilepsy 4 | 792
Vascular disease 4 | 319
Ventricular Septal Defects 4 | 119
cystic fibrosis 4 | 1,696
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Endocrine System 58 | 18,159
Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Female tissues 57 | 17,400
Male tissues 57 | 17,142
Respiratory system 57 | 16,393
Urinary Tract 57 | 16,678
Liver and Pancreas 56 | 16,750
Skin and soft tissues 56 | 17,230
Nervous System 55 | 16,725
Cardiovascular System 54 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 18 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 3 | 242
Kinase 1 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 58 | 58
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.09204 13.1 165
Contactin-1 CNTN1 Tbio Non-IDG -1.93017 87.6 211
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.18767 13.9 219
Contactin-6 CNTN6 Tbio Non-IDG -2.09155 109.6 79
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.65805 49.1 185