Development Level

Tbio 38 | 11,445
Tchem 14 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal behavior 4 | 298
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased circulating phosphat... 2 | 26
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
thrombocytopenia 2 | 56
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal esophagus morphology 1 | 5
abnormal eyelid morphology 1 | 7
abnormal head morphology 1 | 10
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
absent testes 1 | 6
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
irregularly shaped pupil 1 | 7
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16

Disease

ovarian cancer 40 | 8,520
Carcinoma 38 | 11,493
osteosarcoma 37 | 7,950
Cancer 29 | 2,499
glioblastoma 27 | 5,792
medulloblastoma, large-cell 25 | 6,241
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 23 | 5,112
ependymoma 21 | 4,679
Breast cancer 18 | 3,578
lung cancer 17 | 4,740
Kidney cancer 16 | 2,613
adult high grade glioma 15 | 3,801
Astrocytoma, Pilocytic 14 | 3,081
non-small cell lung cancer 14 | 2,890
Multiple myeloma 13 | 1,332
group 3 medulloblastoma 13 | 4,104
lung adenocarcinoma 13 | 2,716
malignant mesothelioma 13 | 3,232
astrocytic glioma 12 | 2,597
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
invasive ductal carcinoma 12 | 2,951
juvenile dermatomyositis 12 | 1,187
lung carcinoma 12 | 2,843
pancreatic cancer 12 | 2,398
subependymal giant cell astrocytoma 12 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Hypertensive disease 10 | 292
Liver Cirrhosis, Experimental 10 | 769
Pick disease 10 | 1,894
ductal carcinoma in situ 10 | 1,745
oligodendroglioma 10 | 2,850
Orbital separation excessive 9 | 244
acute quadriplegic myopathy 9 | 1,158
cystic fibrosis 9 | 1,696
dermatomyositis 9 | 966
group 4 medulloblastoma 9 | 1,855
primary pancreatic ductal adenocarcinoma 9 | 1,109
primitive neuroectodermal tumor 9 | 3,035
Kidney disease 8 | 430
Pulmonary Fibrosis 8 | 106
Schizophrenia 8 | 1,160
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
interstitial cystitis 8 | 2,312
tuberculosis 8 | 2,010
Aortic Valve Insufficiency 7 | 40
Neoplasm Metastasis 7 | 168
Ureteral obstruction 7 | 33
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
pediatric high grade glioma 7 | 1,064
pituitary cancer 7 | 1,972
Acquired scoliosis 6 | 281
Bipolar Disorder 6 | 666
Byzanthine arch palate 6 | 194
Cardiomegaly 6 | 116
Colorectal Neoplasms 6 | 243
Craniofacial Abnormalities 6 | 151
Curvature of spine 6 | 282
Hypertension 6 | 396
Liver Cirrhosis 6 | 181
Liver disease 6 | 237
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Breast Neoplasms 5 | 445
Cleft Palate 5 | 271
Coronary artery disease 5 | 268
Duchenne muscular dystrophy 5 | 601
Increase in blood pressure 5 | 119
Inflammatory bowel disease 5 | 151
Intellectual disability 5 | 1,016
Loeys-Dietz syndrome 5 | 23
Malabsorption 5 | 82
Osteoporosis 5 | 363
Short stature 5 | 531
Vascular disease 5 | 319
cutaneous lupus erythematosus 5 | 1,057
gastric carcinoma 5 | 807
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Depressive disorder 4 | 409
Glaucoma 4 | 239
Heart disease 4 | 306
Hepatomegaly 4 | 285
Liver cancer 4 | 604
Lung Neoplasms 4 | 232
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Strabismus 4 | 270
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
mucosa-associated lymphoid tissue lymphoma 4 | 484

Tissue

Blood and immune system 52 | 16,909
Cardiovascular System 52 | 15,192
Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Liver and Pancreas 51 | 16,750

Target Family

Non-IDG 26 | 12,091
Enzyme 15 | 4,145
Kinase 7 | 634
Transcription Factor 5 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 82 | 82
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 80 | 80
http://pathwaycommons.org/pc2/... 77 | 77
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 71 | 71
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 70 | 70
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 67 | 67
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 66 | 66
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 65 | 65
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 62 | 62
http://pathwaycommons.org/pc2/... 61 | 61
http://pathwaycommons.org/pc2/... 60 | 60
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 58 | 58
http://pathwaycommons.org/pc2/... 57 | 57
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 55 | 55
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 53 | 53
http://pathwaycommons.org/pc2/... 51 | 51
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 50 | 50
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 47 | 47
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 46 | 46
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 45 | 45
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 43 | 43
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 42 | 42
http://pathwaycommons.org/pc2/... 41 | 41
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 40 | 40
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming growth factor-beta receptor-associated protein 1 TGFBRAP1 Tbio Non-IDG -1.03126 9.10 179
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Eukaryotic translation initiation factor 2A EIF2A Tbio Non-IDG -0.62095 4.12 272
Dapper homolog 2 DACT2 Tbio Non-IDG -1.13921 19.1 55
Dynein light chain roadblock-type 1 DYNLRB1 Tbio Non-IDG -2.23639 168.6 41
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Zinc finger FYVE domain-containing protein 16 ZFYVE16 Tbio Non-IDG -0.84581 9.36 116
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605