Development Level

Tbio 32 | 11,445
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal placement of pupils 1 | 6
absent testes 1 | 6
corneal opacity 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
short tibia 1 | 97
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 30 | 11,493
ovarian cancer 27 | 8,520
osteosarcoma 24 | 7,950
psoriasis 23 | 6,694
medulloblastoma, large-cell 22 | 6,241
Cancer 21 | 2,499
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 15 | 4,679
Breast cancer 14 | 3,578
non-small cell lung cancer 14 | 2,890
oligodendroglioma 14 | 2,850
Pick disease 13 | 1,894
lung cancer 13 | 4,740
Astrocytoma, Pilocytic 12 | 3,081
group 3 medulloblastoma 12 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
invasive ductal carcinoma 12 | 2,951
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
adult high grade glioma 11 | 3,801
astrocytic glioma 11 | 2,597
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
cystic fibrosis 10 | 1,696
tuberculosis 10 | 2,010
juvenile dermatomyositis 9 | 1,187
ductal carcinoma in situ 8 | 1,745
interstitial cystitis 8 | 2,312
pancreatic cancer 8 | 2,398
Fibrodysplasia ossificans progressiva 7 | 17
Kidney cancer 7 | 2,613
Short stature 7 | 531
acute myeloid leukemia 7 | 783
colon cancer 7 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
subependymal giant cell astrocytoma 7 | 2,287
Brachydactyly 6 | 156
Rheumatoid arthritis 6 | 1,191
Stomach Neoplasms 6 | 300
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
pediatric high grade glioma 6 | 1,064
Amyotrophic lateral sclerosis 5 | 451
Anemia 5 | 365
Atopic dermatitis 5 | 952
Duchenne muscular dystrophy 5 | 601
Multiple myeloma 5 | 1,332
Myopia 5 | 176
Orbital separation excessive 5 | 244
Osteoarthritis 5 | 184
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
diabetes mellitus 5 | 1,728
gastric carcinoma 5 | 807
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Bilateral fifth finger clinodactyly 4 | 110
Breast Neoplasms 4 | 445
Cognitive delay 4 | 608
Colorectal Neoplasms 4 | 243
Craniofacial Abnormalities 4 | 151
Curvature of little finger 4 | 110
Downward slant of palpebral fissure 4 | 158
Global developmental delay 4 | 608
Hemochromatosis 4 | 54
Hypoplastic feet 4 | 66
Liver Cirrhosis, Experimental 4 | 769
Mammary Neoplasms 4 | 425
Mental and motor retardation 4 | 608
Osteoporosis 4 | 363
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Simple syndactyly of toes, first web space 4 | 23
Vascular disease 4 | 319
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
spina bifida 4 | 1,074
Autistic Disorder 3 | 364
Bipolar Disorder 3 | 666
Congenital Epicanthus 3 | 177
Craniosynostosis 3 | 74
Eye Abnormalities 3 | 35
Failure to gain weight 3 | 365
Flexion contracture of proximal interphalangeal joint 3 | 75
Hemoglobin low 3 | 124
Hypertension 3 | 396
Kidney disease 3 | 430
Microstomia 3 | 78
Pediatric failure to thrive 3 | 365
Strabismus 3 | 270
esophageal adenocarcinoma 3 | 737
nasopharyngeal carcinoma 3 | 1,058
progressive supranuclear palsy 3 | 676

Tissue

Digestive Tract 42 | 17,369
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Nervous System 41 | 16,725
Blood and immune system 40 | 16,909
Cardiovascular System 39 | 15,192
Respiratory system 39 | 16,393

Target Family

Non-IDG 19 | 12,091
Enzyme 10 | 4,145
Kinase 7 | 634
Transcription Factor 6 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.21660 1658.5 540
Bone morphogenetic protein 7 BMP7 Tbio Non-IDG -3.16189 1536.8 736
E3 ubiquitin-protein ligase XIAP XIAP Tchem Enzyme -3.13488 1375.8 504
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Alpha-2-HS-glycoprotein AHSG Tbio Non-IDG -3.09085 1300.3 437
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Follistatin FST Tbio Non-IDG -3.07812 1179.4 356
Noggin NOG Tbio Non-IDG -2.95258 841.0 338
Gremlin-1 GREM1 Tbio Non-IDG -2.91296 826.9 397