Development Level

Tbio 29 | 11,651
Tchem 11 | 1,388
Tclin 5 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
decreased bone mineral density 2 | 126
impaired glucose tolerance 2 | 75
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
increased circulating alkaline... 1 | 122
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 30 | 11,493
Obesity 24 | 678
diabetes mellitus 24 | 1,728
psoriasis 24 | 6,694
Cancer 23 | 2,499
ovarian cancer 20 | 8,520
Autosomal recessive predisposition 18 | 1,442
Hyperglycemia 17 | 137
Hypoglycemia 17 | 152
medulloblastoma, large-cell 17 | 6,241
Epilepsy 15 | 792
glioblastoma 15 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Seizures 13 | 596
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung cancer 13 | 4,740
lung carcinoma 13 | 2,843
osteosarcoma 13 | 7,950
ulcerative colitis 13 | 1,819
Hyperinsulinism 12 | 133
Liver Cirrhosis, Experimental 12 | 769
malignant mesothelioma 12 | 3,232
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Hepatomegaly 11 | 285
Mental and motor retardation 11 | 608
invasive ductal carcinoma 11 | 2,951
Breast cancer 10 | 3,578
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Diabetes Mellitus, Type 2 10 | 142
Diarrhea 10 | 253
Dull intelligence 10 | 645
Intellectual disability 10 | 1,016
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Schizophrenia 10 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
primitive neuroectodermal tumor 10 | 3,035
Alzheimer's disease 9 | 658
Diabetes Mellitus, Experimental 9 | 108
Hypertension 9 | 396
Hypertensive disease 9 | 292
Kidney disease 9 | 430
Lethargy 9 | 77
Lipid metabolism disorder 9 | 114
Liver carcinoma 9 | 240
Vomiting 9 | 116
astrocytoma 9 | 1,146
atypical teratoid / rhabdoid tumor 9 | 5,112
breast carcinoma 9 | 1,638
group 3 medulloblastoma 9 | 4,104
Anemia 8 | 365
Carcinoma, Hepatocellular 8 | 228
Comatose 8 | 56
Glycosuria 8 | 29
Hyperinsulinemic hypoglycemia 8 | 17
Muscle Weakness 8 | 170
Neuropathy 8 | 261
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 4,679
maturity-onset diabetes of the young 8 | 32
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Adenoma 7 | 167
Blepharoptosis 7 | 231
Diabetes Mellitus, Noninsulin-Dependent 7 | 31
Failure to gain weight 7 | 365
Fatty liver disease 7 | 103
Hyperinsulinaemic hypoglycaemia 7 | 16
Hypoketotic hypoglycemia 7 | 11
Pediatric failure to thrive 7 | 365
Peripheral Neuropathy 7 | 134
Pick disease 7 | 1,894
adult high grade glioma 7 | 3,801
colon cancer 7 | 1,478
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
Cerebrovascular disease 6 | 238
Congenital heart disease 6 | 93
Elevated hepatic transaminases 6 | 81
Fetal Growth Retardation 6 | 189
Heart disease 6 | 306
Hepatic enzyme increased 6 | 81
Kidney cancer 6 | 2,613
Liver Dysfunction 6 | 99
Liver enzymes abnormal 6 | 81
Liver function test increased 6 | 81
Liver function tests abnormal finding 6 | 81
Mammary Neoplasms 6 | 425
Motor delay 6 | 147
No development of motor milestones 6 | 147
Prostatic Neoplasms 6 | 495
Subclinical abnormal liver function tests 6 | 81
Tachycardia 6 | 43
Transaminases increased 6 | 81
Type 2 diabetes mellitus 6 | 272
acute quadriplegic myopathy 6 | 1,158
lung adenocarcinoma 6 | 2,716
pituitary cancer 6 | 1,972

Tissue

Digestive Tract 44 | 17,369
Endocrine System 44 | 18,159
Liver and Pancreas 44 | 16,750
Skin and soft tissues 43 | 17,230
Urinary Tract 42 | 16,678
Blood and immune system 40 | 16,909
Female tissues 40 | 17,400
Male tissues 40 | 17,142
Nervous System 38 | 16,725
Respiratory system 37 | 16,393
Cardiovascular System 34 | 15,192

Target Family

Enzyme 14 | 4,145
Transcription Factor 12 | 1,400
Non-IDG 10 | 12,091
Kinase 4 | 634
Nuclear Receptor 2 | 48
Transporter 2 | 473
Ion Channel 1 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carnitine O-palmitoyltransferase 1, liver isoform CPT1A Tchem Enzyme -2.38489 225.0 306
Transthyretin TTR Tclin Non-IDG -3.79596 6198.3 750
Tyrosine aminotransferase TAT Tbio Enzyme -3.06741 1138.7 162
Hepatocyte nuclear factor 4-alpha HNF4A Tchem Nuclear Receptor -3.19918 1373.3 664
Insulin INS Tbio Non-IDG -5.17849 146933.7 2197
Apolipoprotein A-I APOA1 Tbio Non-IDG -3.62534 3592.8 1151
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial ACADVL Tbio Enzyme -2.27608 186.5 190
Transcription factor Sp1 SP1 Tbio Transcription Factor -3.01541 976.7 780
Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 Tchem Transporter -2.81915 616.6 291
Glucokinase GCK Tchem Kinase -2.90428 758.6 336