Development Level

Tchem 9 | 1,598
Tclin 7 | 613
Tbio 5 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal gait 1 | 69
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278

Disease

Carcinoma 16 | 11,493
ovarian cancer 15 | 8,520
Cancer 14 | 2,499
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
lung cancer 12 | 4,740
osteosarcoma 12 | 7,950
medulloblastoma, large-cell 10 | 6,241
Breast cancer 9 | 3,578
adult high grade glioma 9 | 3,801
Obesity 8 | 678
Schizophrenia 8 | 1,160
atypical teratoid / rhabdoid tumor 8 | 5,112
diabetes mellitus 8 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
malignant mesothelioma 8 | 3,232
Asthma 7 | 385
Astrocytoma, Pilocytic 7 | 3,081
Kidney disease 7 | 430
lung carcinoma 7 | 2,843
primitive neuroectodermal tumor 7 | 3,035
Arthritis 6 | 290
Brain Ischemia 6 | 110
Depressive disorder 6 | 409
Endometriosis 6 | 540
Heart disease 6 | 306
Inflammatory bowel disease 6 | 151
Lung Neoplasms 6 | 232
Mental Depression 6 | 333
Multiple Sclerosis 6 | 540
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
cystic fibrosis 6 | 1,696
ependymoma 6 | 4,679
juvenile dermatomyositis 6 | 1,187
pancreatic cancer 6 | 2,398
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Alzheimer's disease 5 | 658
Atherosclerosis 5 | 291
Bipolar Disorder 5 | 666
Breast Neoplasms 5 | 445
Coronary artery disease 5 | 268
Dermatitis 5 | 157
Disease Models, Animal 5 | 155
Hyperglycemia 5 | 137
Hypersensitivity 5 | 63
Hypersensitivity reaction type II disease 5 | 253
Hypertension 5 | 396
Kidney cancer 5 | 2,613
Lung disease 5 | 142
Mammary Neoplasms 5 | 425
Neoplasm Invasiveness 5 | 161
Neoplasm Metastasis 5 | 168
Radiation Injuries, Experimental 5 | 11
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
sarcoidosis 5 | 370
Adenocarcinoma 4 | 122
Cardiomyopathies 4 | 110
Cholestasis, Extrahepatic 4 | 25
Diarrhea 4 | 253
Eye disease 4 | 62
Female infertility 4 | 30
Glomerulonephritis 4 | 46
Hyperalgesia 4 | 83
Hypertensive disease 4 | 292
Infertility 4 | 188
Liver Cirrhosis, Experimental 4 | 769
Major Depressive Disorder 4 | 301
Mammary Neoplasms, Experimental 4 | 154
Multiple myeloma 4 | 1,332
Neurodegenerative disease 4 | 414
Osteoporosis 4 | 363
Parkinson's disease 4 | 392
Pick disease 4 | 1,894
Pneumonia 4 | 174
Premature Birth 4 | 77
Prostatic Neoplasms 4 | 495
Salmonellosis 4 | 42
Stomach Neoplasms 4 | 300
Synovitis 4 | 78
Toxic encephalopathy 4 | 141
Trigeminal Neuralgia 4 | 24
Unipolar Depression 4 | 250
Urticaria 4 | 67
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 807
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non-small cell lung cancer 4 | 2,890
Allergic rhinitis 3 | 94
Hypereosinophilic syndrome 3 | 71
Vasculitis 3 | 80
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478

Tissue

Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678
Cardiovascular System 20 | 15,192
Nervous System 20 | 16,725

Target Family

Kinase 8 | 634
Non-IDG 8 | 12,091
Nuclear Receptor 3 | 48
Enzyme 2 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 21 | 21
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
NACHT, LRR and PYD domains-containing protein 1 NLRP1 Tbio Non-IDG -2.03558 116.5 183
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636