Development Level

Tbio 10 | 11,445
Tchem 9 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
absent seminal vesicle 1 | 4
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased hematocrit 1 | 46
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
male infertility 1 | 123
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
small uterus 1 | 3

Disease

Cancer 16 | 2,499
osteosarcoma 15 | 7,950
Carcinoma 14 | 11,493
ovarian cancer 14 | 8,520
psoriasis 12 | 6,694
lung cancer 10 | 4,740
Breast cancer 8 | 3,578
glioblastoma 8 | 5,792
group 3 medulloblastoma 7 | 4,104
lung adenocarcinoma 7 | 2,716
medulloblastoma, large-cell 7 | 6,241
pancreatic cancer 7 | 2,398
Neoplasm Invasiveness 6 | 161
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
primary pancreatic ductal adenocarcinoma 6 | 1,109
Astrocytoma, Pilocytic 5 | 3,081
Multiple myeloma 5 | 1,332
Neoplasm Metastasis 5 | 168
Schizophrenia 5 | 1,160
Stomach Neoplasms 5 | 300
Vascular disease 5 | 319
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Arthritis 4 | 290
Bladder Neoplasm 4 | 112
Cardiomyopathies 4 | 110
Down syndrome 4 | 499
Gliosis 4 | 56
Heart disease 4 | 306
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Lung Neoplasms 4 | 232
Mental Depression 4 | 333
Urinary Bladder Neoplasms 4 | 114
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Asthma 3 | 385
Bipolar Disorder 3 | 666
Brain Ischemia 3 | 110
Carcinoma, Squamous Cell 3 | 110
Cerebrovascular disease 3 | 238
Cocaine-Related Disorders 3 | 92
Colonic Neoplasms 3 | 142
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Gastrointestinal system disease 3 | 54
Heart failure 3 | 162
Hyperalgesia 3 | 83
Hypertension 3 | 396
Hypertrophy 3 | 17
Ovarian Neoplasms 3 | 102
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Reperfusion Injury 3 | 86
Rheumatoid arthritis 3 | 1,191
Squamous cell carcinoma 3 | 129
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
ovarian neoplasm 3 | 99
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
Arthritis, Juvenile 2 | 126
Atherosclerosis 2 | 291
Carcinoma, Hepatocellular 2 | 228
Cardiomyopathy, Dilated 2 | 83
Cholestasis 2 | 155
Chronic obstructive pulmonary disease 2 | 184
Endometriosis 2 | 540
Juvenile arthritis 2 | 126
Liver carcinoma 2 | 240
Lung disease 2 | 142
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Myocardial Ischemia 2 | 169
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
limb girdle muscular dystrophy 2A 2 | 213
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562

Tissue

Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 7 | 12,091
Kinase 5 | 634
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Protein tyrosine phosphatase type IVA 3 PTP4A3 Tchem Enzyme -1.40644 30.3 279
Cyclic AMP-dependent transcription factor ATF-5 ATF5 Tbio Transcription Factor -1.80759 80.3 220
Angiotensinogen AGT Tbio Non-IDG -3.24591 1711.3 695
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Geranylgeranyl transferase type-2 subunit beta RABGGTB Tbio Enzyme -0.69980 4.51 47
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43737 3042.8 1509
Protein tyrosine phosphatase type IVA 1 PTP4A1 Tchem Enzyme -1.83187 67.0 213