Development Level

Tbio 29 | 11,445
Tchem 12 | 1,598
Tclin 7 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased vertical activity 2 | 208
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

ovarian cancer 37 | 8,520
Carcinoma 36 | 11,493
Cancer 34 | 2,499
glioblastoma 27 | 5,792
psoriasis 25 | 6,694
medulloblastoma, large-cell 24 | 6,241
lung cancer 23 | 4,740
Breast cancer 21 | 3,578
osteosarcoma 21 | 7,950
malignant mesothelioma 18 | 3,232
ependymoma 17 | 4,679
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
atypical teratoid / rhabdoid tumor 15 | 5,112
invasive ductal carcinoma 15 | 2,951
adult high grade glioma 14 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
oligodendroglioma 14 | 2,850
Astrocytoma, Pilocytic 13 | 3,081
astrocytoma 13 | 1,146
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
astrocytic glioma 12 | 2,597
group 3 medulloblastoma 12 | 4,104
lung adenocarcinoma 12 | 2,716
primitive neuroectodermal tumor 12 | 3,035
Kidney cancer 11 | 2,613
Short stature 11 | 531
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
tuberculosis 11 | 2,010
Intellectual disability 10 | 1,016
Prostatic Neoplasms 10 | 495
interstitial cystitis 10 | 2,312
pituitary cancer 10 | 1,972
subependymal giant cell astrocytoma 10 | 2,287
Failure to gain weight 9 | 365
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Pediatric failure to thrive 9 | 365
Rheumatoid arthritis 9 | 1,191
breast carcinoma 9 | 1,638
ductal carcinoma in situ 9 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
ulcerative colitis 9 | 1,819
Brachydactyly 8 | 156
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
pancreatic cancer 8 | 2,398
Alzheimer's disease 7 | 658
Bilateral fifth finger clinodactyly 7 | 110
Cleft Palate 7 | 271
Curvature of little finger 7 | 110
Dull intelligence 7 | 645
Endometriosis 7 | 540
Immune system cancer 7 | 140
Low intelligence 7 | 645
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
Poor school performance 7 | 645
Small head 7 | 374
Strabismus 7 | 270
Uranostaphyloschisis 7 | 167
acute quadriplegic myopathy 7 | 1,158
juvenile dermatomyositis 7 | 1,187
Acquired scoliosis 6 | 281
Broad flat nasal bridge 6 | 236
Colorectal Neoplasms 6 | 243
Congenital Epicanthus 6 | 177
Convex nasal ridge 6 | 37
Cryptorchidism 6 | 296
Curvature of spine 6 | 282
Exophthalmos 6 | 112
Fetal Growth Retardation 6 | 189
Heart disease 6 | 306
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Isolated cases 6 | 72
Low set ears 6 | 181
Nasal bridge wide 6 | 236
Obesity 6 | 678
Orbital separation excessive 6 | 244
Pick disease 6 | 1,894
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Schizophrenia 6 | 1,160
pediatric high grade glioma 6 | 1,064
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Bipolar Disorder 5 | 666
adrenocortical carcinoma 5 | 1,428
gastric carcinoma 5 | 807
primary Sjogren syndrome 5 | 735

Tissue

Digestive Tract 48 | 17,369
Endocrine System 47 | 18,159
Female tissues 47 | 17,400
Male tissues 47 | 17,142
Liver and Pancreas 46 | 16,750
Nervous System 46 | 16,725
Skin and soft tissues 46 | 17,230
Blood and immune system 45 | 16,909
Respiratory system 45 | 16,393
Cardiovascular System 44 | 15,192
Urinary Tract 44 | 16,678

Target Family

Transcription Factor 23 | 1,400
Non-IDG 11 | 12,091
Enzyme 5 | 4,145
Epigenetic 5 | 242
Kinase 3 | 634
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.44791 277.6 405
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.60800 401.4 317
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Msx2-interacting protein SPEN Tbio Non-IDG -2.94650 839.8 43
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Transcription cofactor HES-6 HES6 Tbio Transcription Factor -1.72013 55.3 218
Transcriptional activator Myb MYB Tbio Transcription Factor -2.97697 938.9 642