Development Level

Tbio 25 | 11,445
Tchem 4 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased vertical activity 3 | 208
preweaning lethality, complete... 3 | 979
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retinal outer nuclear... 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
female infertility 1 | 60
hydrometra 1 | 53
hydrops fetalis 1 | 1
increased circulating insulin ... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
microphthalmia 1 | 26
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 20 | 11,493
psoriasis 19 | 6,694
ovarian cancer 16 | 8,520
Cancer 15 | 2,499
osteosarcoma 15 | 7,950
atypical teratoid / rhabdoid tumor 13 | 5,112
medulloblastoma, large-cell 13 | 6,241
glioblastoma 12 | 5,792
group 3 medulloblastoma 12 | 4,104
interstitial cystitis 12 | 2,312
ependymoma 11 | 4,679
Breast cancer 9 | 3,578
lung adenocarcinoma 9 | 2,716
non-small cell lung cancer 9 | 2,890
Autosomal recessive predisposition 8 | 1,442
breast carcinoma 8 | 1,638
cystic fibrosis 8 | 1,696
lung cancer 8 | 4,740
primitive neuroectodermal tumor 8 | 3,035
malignant mesothelioma 7 | 3,232
Astrocytoma, Pilocytic 6 | 3,081
Osteoporosis 6 | 363
adrenocortical carcinoma 6 | 1,428
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
osteoporosis-pseudoglioma syndrome 6 | 9
pediatric high grade glioma 6 | 1,064
Hypoplastic mandible condyle 5 | 275
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Orbital separation excessive 5 | 244
ductal carcinoma in situ 5 | 1,745
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
Big calvaria 4 | 147
Broad flat nasal bridge 4 | 236
Cleft Palate 4 | 271
Cryptorchidism 4 | 296
Dull intelligence 4 | 645
Frequent fractures 4 | 53
Frontal bossing 4 | 157
Hypotrophic malar bone 4 | 129
Increased fracture rate 4 | 53
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Infantile onset 4 | 238
Intellectual disability 4 | 1,016
Juvenile osteoporosis 4 | 4
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Malar flattening 4 | 129
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nasal bridge wide 4 | 236
Osteoporosis, Juvenile 4 | 4
Poor school performance 4 | 645
Robinow syndrome 4 | 11
Short stature 4 | 531
Varying degree of multiple fractures 4 | 53
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Atopic dermatitis 3 | 952
Bone pain 3 | 42
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Congenital clinodactyly 3 | 57
Congenital hypoplasia of penis 3 | 176
Craniofacial Abnormalities 3 | 151
Curvature of digit 3 | 57
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Duchenne muscular dystrophy 3 | 601
Exophthalmos 3 | 112
Gait abnormality 3 | 135
Global developmental delay 3 | 608
Long philtrum 3 | 137
Mental and motor retardation 3 | 608
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Slow progression 3 | 89
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
tuberculosis 3 | 2,010

Tissue

Digestive Tract 29 | 17,369
Female tissues 29 | 17,400
Blood and immune system 28 | 16,909
Endocrine System 28 | 18,159
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Skin and soft tissues 28 | 17,230
Liver and Pancreas 26 | 16,750
Respiratory system 26 | 16,393
Urinary Tract 26 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 18 | 12,091
GPCR 9 | 408
Kinase 2 | 634

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Collagen triple helix repeat-containing protein 1 CTHRC1 Tbio Non-IDG -1.72221 62.3 202
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Wnt inhibitory factor 1 WIF1 Tbio Non-IDG -2.11284 143.2 350
Kremen protein 1 KREMEN1 Tbio Non-IDG -1.25099 14.5 263