Development Level

Tbio 52 | 11,445
Tchem 26 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 5 | 239
enlarged heart 4 | 210
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
small testis 3 | 58
abnormal behavior 2 | 298
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal testis morphology 2 | 43
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
short tibia 2 | 97
abnormal allantois morphology 1 | 8
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart looping 1 | 5
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal spleen morphology 1 | 55
abnormal tail bud morphology 1 | 8
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
cataract 1 | 92
convulsive seizures 1 | 13
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased granulocyte number 1 | 6
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
urinary bladder obstruction 1 | 4

Disease

Cancer 61 | 2,499
ovarian cancer 59 | 8,520
Carcinoma 58 | 11,493
osteosarcoma 50 | 7,950
glioblastoma 46 | 5,792
psoriasis 46 | 6,694
lung cancer 44 | 4,740
medulloblastoma, large-cell 41 | 6,241
Breast cancer 33 | 3,578
atypical teratoid / rhabdoid tumor 33 | 5,112
malignant mesothelioma 27 | 3,232
group 3 medulloblastoma 26 | 4,104
invasive ductal carcinoma 26 | 2,951
pancreatic cancer 25 | 2,398
Rheumatoid arthritis 24 | 1,191
ependymoma 23 | 4,679
adult high grade glioma 22 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
primitive neuroectodermal tumor 22 | 3,035
non-small cell lung cancer 21 | 2,890
subependymal giant cell astrocytoma 21 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
lung adenocarcinoma 20 | 2,716
ulcerative colitis 20 | 1,819
ductal carcinoma in situ 19 | 1,745
pituitary cancer 19 | 1,972
Kidney cancer 18 | 2,613
astrocytic glioma 18 | 2,597
oligodendroglioma 18 | 2,850
breast carcinoma 17 | 1,638
tuberculosis 17 | 2,010
Astrocytoma, Pilocytic 16 | 3,081
cystic fibrosis 16 | 1,696
group 4 medulloblastoma 16 | 1,855
lung carcinoma 16 | 2,843
Multiple myeloma 15 | 1,332
primary pancreatic ductal adenocarcinoma 15 | 1,109
Breast Neoplasms 14 | 445
Carcinoma, Hepatocellular 14 | 228
Immune system cancer 14 | 140
Liver carcinoma 14 | 240
acute quadriplegic myopathy 14 | 1,158
diabetes mellitus 14 | 1,728
juvenile dermatomyositis 14 | 1,187
Anemia 13 | 365
Mammary Neoplasms 13 | 425
Prostatic Neoplasms 13 | 495
adrenocortical carcinoma 13 | 1,428
astrocytoma 13 | 1,146
colon cancer 13 | 1,478
Bipolar Disorder 12 | 666
Bladder Neoplasm 12 | 112
Pick disease 12 | 1,894
Short stature 12 | 531
Stomach Neoplasms 12 | 300
Urinary Bladder Neoplasms 12 | 114
acute myeloid leukemia 12 | 783
interstitial cystitis 12 | 2,312
Intellectual disability 11 | 1,016
Liver Cirrhosis, Experimental 11 | 769
Lung Neoplasms 11 | 232
Lymphoid leukemia 11 | 160
Schizophrenia 11 | 1,160
Waldenstrons macroglobulinemia 11 | 765
cutaneous lupus erythematosus 11 | 1,057
nasopharyngeal carcinoma 11 | 1,058
Acquired scoliosis 10 | 281
Adenoma 10 | 167
Asthma 10 | 385
Autistic Disorder 10 | 364
Autosomal recessive predisposition 10 | 1,442
Carcinoma, Squamous Cell 10 | 110
Curvature of spine 10 | 282
Dull intelligence 10 | 645
Isolated cases 10 | 72
Leukemia, Myelocytic, Acute 10 | 120
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Muscle hypotonia 10 | 571
Poor school performance 10 | 645
Squamous cell carcinoma 10 | 129
Alzheimer's disease 9 | 658
Cryptorchidism 9 | 296
Diarrhea 9 | 253
Epilepsy 9 | 792
Hypoplastic mandible condyle 9 | 275
Leukemia, Myeloid, Acute 9 | 105
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Obesity 9 | 678
Parkinson's disease 9 | 392
Seizures 9 | 596
Splenomegaly 9 | 190
sarcoidosis 9 | 370
Small head 8 | 374
dermatomyositis 8 | 966
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary Sjogren syndrome 8 | 735

Tissue

Digestive Tract 84 | 17,369
Blood and immune system 83 | 16,909
Endocrine System 83 | 18,159
Female tissues 83 | 17,400
Male tissues 83 | 17,142
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Liver and Pancreas 82 | 16,750
Nervous System 81 | 16,725
Respiratory system 81 | 16,393
Cardiovascular System 76 | 15,192

Target Family

Non-IDG 25 | 12,091
Transcription Factor 22 | 1,400
Enzyme 21 | 4,145
Kinase 8 | 634
Epigenetic 7 | 242
Transporter 3 | 473
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
Phosphate carrier protein, mitochondrial SLC25A3 Tbio Transporter -2.85426 703.4 33
Aminopeptidase N ANPEP Tchem Enzyme -3.28127 1843.4 1222
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Hematopoietic progenitor cell antigen CD34 CD34 Tbio Non-IDG -4.14691 13698.4 1952
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174