Development Level

Tchem 23 | 1,598
Tbio 21 | 11,445
Tclin 12 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 5 | 979
decreased vertical activity 3 | 208
abnormal behavior 2 | 298
abnormal testis morphology 2 | 43
decreased circulating alanine ... 2 | 47
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
increased circulating alkaline... 2 | 122
male infertility 2 | 123
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal duodenum morphology 1 | 4
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
shortened RR interval 1 | 17
vertebral fusion 1 | 23

Disease

Carcinoma 44 | 11,493
osteosarcoma 40 | 7,950
ovarian cancer 32 | 8,520
Cancer 29 | 2,499
medulloblastoma, large-cell 28 | 6,241
glioblastoma 26 | 5,792
psoriasis 25 | 6,694
lung cancer 22 | 4,740
lung carcinoma 22 | 2,843
non-small cell lung cancer 20 | 2,890
adult high grade glioma 19 | 3,801
atypical teratoid / rhabdoid tumor 19 | 5,112
ependymoma 19 | 4,679
interstitial cystitis 18 | 2,312
Astrocytoma, Pilocytic 17 | 3,081
diabetes mellitus 16 | 1,728
invasive ductal carcinoma 16 | 2,951
group 3 medulloblastoma 15 | 4,104
subependymal giant cell astrocytoma 15 | 2,287
ulcerative colitis 15 | 1,819
lung adenocarcinoma 14 | 2,716
malignant mesothelioma 14 | 3,232
oligodendroglioma 14 | 2,850
primitive neuroectodermal tumor 14 | 3,035
Breast cancer 13 | 3,578
Kidney cancer 13 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Hypertension 12 | 396
Schizophrenia 12 | 1,160
group 4 medulloblastoma 12 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Rheumatoid arthritis 11 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
pancreatic cancer 11 | 2,398
primary Sjogren syndrome 11 | 735
tuberculosis 11 | 2,010
Asthma 10 | 385
Liver Cirrhosis, Experimental 10 | 769
Pick disease 10 | 1,894
cutaneous lupus erythematosus 10 | 1,057
Bipolar Disorder 9 | 666
Blastic phase chronic myeloid leukemia 9 | 58
Cardiomegaly 9 | 116
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Depressive disorder 9 | 409
Heart disease 9 | 306
Hypertensive disease 9 | 292
Kidney disease 9 | 430
Lung disease 9 | 142
Waldenstrons macroglobulinemia 9 | 765
active ulcerative colitis 9 | 764
astrocytic glioma 9 | 2,597
astrocytoma 9 | 1,146
Obesity 8 | 678
cystic fibrosis 8 | 1,696
ductal carcinoma in situ 8 | 1,745
pituitary cancer 8 | 1,972
Breast Neoplasms 7 | 445
Cerebrovascular disease 7 | 238
Chronic phase chronic myeloid leukemia 7 | 45
Coronary artery disease 7 | 268
Mammary Neoplasms 7 | 425
Melanoma 7 | 711
Myocardial Ischemia 7 | 169
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 7 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 7 | 47
Stomach Neoplasms 7 | 300
adrenocortical carcinoma 7 | 1,428
colon cancer 7 | 1,478
juvenile dermatomyositis 7 | 1,187
primary pancreatic ductal adenocarcinoma 7 | 1,109
Allergic rhinitis 6 | 94
Arthritis 6 | 290
Atherosclerosis 6 | 291
Cardiovascular Diseases 6 | 59
Colorectal Neoplasms 6 | 243
Crohn's disease 6 | 321
Intellectual disability 6 | 1,016
Multiple myeloma 6 | 1,332
Prostatic Neoplasms 6 | 495
Vascular disease 6 | 319
active Crohn's disease 6 | 922
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
sarcoidosis 6 | 370
Alzheimer's disease 5 | 658
Cardiomyopathies 5 | 110
Dermatitis 5 | 157
Diabetes Mellitus, Experimental 5 | 108
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Hypersensitivity reaction type II disease 5 | 253
Impotence 5 | 42
Mental Depression 5 | 333
Multiple Sclerosis 5 | 540
Peripheral vascular disease 5 | 87
Skin cancer 5 | 469
esophageal adenocarcinoma 5 | 737
mucosa-associated lymphoid tissue lymphoma 5 | 484
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
spina bifida 5 | 1,074

Tissue

Blood and immune system 56 | 16,909
Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Skin and soft tissues 56 | 17,230
Cardiovascular System 55 | 15,192
Respiratory system 55 | 16,393
Urinary Tract 55 | 16,678

Target Family

Kinase 27 | 634
Non-IDG 18 | 12,091
Enzyme 7 | 4,145
GPCR 3 | 408
Transporter 1 | 473

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
http://pathwaycommons.org/pc2/... 87 | 87
http://pathwaycommons.org/pc2/... 87 | 87
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http://pathwaycommons.org/pc2/... 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Protein kinase C gamma type PRKCG Tchem Kinase -2.04120 103.9 435
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 SLC9A3R1 Tbio Transporter -3.11679 1295.9 249
Thromboxane A2 receptor TBXA2R Tclin GPCR -2.17674 123.4 112