Development Level

Tchem 13 | 1,598
Tbio 11 | 11,445
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
decreased bone mineral content 1 | 151
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
small superior vagus ganglion 1 | 74

Disease

Cancer 23 | 2,499
Carcinoma 18 | 11,493
ovarian cancer 18 | 8,520
glioblastoma 16 | 5,792
lung cancer 13 | 4,740
osteosarcoma 12 | 7,950
atypical teratoid / rhabdoid tumor 11 | 5,112
psoriasis 11 | 6,694
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Autosomal recessive predisposition 8 | 1,442
Breast cancer 8 | 3,578
ependymoma 8 | 4,679
medulloblastoma, large-cell 8 | 6,241
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
Arthritis 6 | 290
Stomach Neoplasms 6 | 300
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Breast Neoplasms 5 | 445
Failure to gain weight 5 | 365
Kidney cancer 5 | 2,613
Lung Neoplasms 5 | 232
Mammary Neoplasms 5 | 425
Neoplasm Metastasis 5 | 168
Pediatric failure to thrive 5 | 365
Schizophrenia 5 | 1,160
acute myeloid leukemia 5 | 783
cutaneous lupus erythematosus 5 | 1,057
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
oligodendroglioma 5 | 2,850
Dull intelligence 4 | 645
Gaucher disease type 1 4 | 180
Hyperglycemia 4 | 137
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Ovarian Neoplasms 4 | 102
Pick disease 4 | 1,894
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
Short stature 4 | 531
Splenomegaly 4 | 190
Squamous cell carcinoma 4 | 129
Vascular disease 4 | 319
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,855
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Asthma 3 | 385
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Epilepsy 3 | 792
Fatigue 3 | 182
Frontal bossing 3 | 157
Global developmental delay 3 | 608
Hyperalgesia 3 | 83
Immunologic Deficiency Syndromes 3 | 113
Infantile onset 3 | 238
Kidney Neoplasm 3 | 29
Kidney Neoplasms 3 | 37
Lens Opacities 3 | 231
Leukemia 3 | 104
Liver carcinoma 3 | 240
Mental and motor retardation 3 | 608
Multiple Sclerosis 3 | 540
Neoplasm Invasiveness 3 | 161
Neurodegenerative disease 3 | 414
Osteoporosis 3 | 363
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Parkinson's disease 3 | 392
Seizures 3 | 596
Small head 3 | 374
Somatic mutation 3 | 61
Toxic encephalopathy 3 | 141
Type 2 diabetes mellitus 3 | 272
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
pancreatic carcinoma 3 | 562
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Kinase 12 | 634
Non-IDG 10 | 12,091
Enzyme 3 | 4,145

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
28S ribosomal protein S29, mitochondrial DAP3 Tbio Non-IDG -1.22289 22.6 312
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Tumor necrosis factor ligand superfamily member 10 TNFSF10 Tbio Non-IDG -2.87006 661.9 949
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683