Development Level

Tbio 16 | 11,445
Tchem 10 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
fused cornea and lens 1 | 5
fused phalanges 1 | 1
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 28 | 11,493
ovarian cancer 24 | 8,520
osteosarcoma 21 | 7,950
glioblastoma 19 | 5,792
psoriasis 19 | 6,694
Cancer 18 | 2,499
medulloblastoma, large-cell 18 | 6,241
atypical teratoid / rhabdoid tumor 17 | 5,112
oligodendroglioma 15 | 2,850
Kidney cancer 14 | 2,613
Astrocytoma, Pilocytic 13 | 3,081
ependymoma 13 | 4,679
Breast cancer 12 | 3,578
group 3 medulloblastoma 12 | 4,104
lung cancer 12 | 4,740
astrocytic glioma 11 | 2,597
primitive neuroectodermal tumor 10 | 3,035
pancreatic cancer 9 | 2,398
Intellectual disability 8 | 1,016
Liver cancer 8 | 604
Pick disease 8 | 1,894
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Renal Cell Carcinoma 7 | 214
Schizophrenia 7 | 1,160
Stomach Neoplasms 7 | 300
diabetes mellitus 7 | 1,728
group 4 medulloblastoma 7 | 1,855
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Neoplasm Invasiveness 6 | 161
Rheumatoid arthritis 6 | 1,191
cystic fibrosis 6 | 1,696
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
Endometrial cancer 5 | 311
Multiple myeloma 5 | 1,332
Neoplasm Metastasis 5 | 168
Squamous cell carcinoma 5 | 129
Vascular disease 5 | 319
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung carcinoma 5 | 2,843
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
Alzheimer's disease 4 | 658
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Carcinoma, Renal Cell 4 | 124
Carcinoma, Squamous Cell 4 | 110
Cognitive delay 4 | 608
Colorectal cancer 4 | 25
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Kidney disease 4 | 430
Low intelligence 4 | 645
Lung Neoplasms 4 | 232
Melanoma 4 | 711
Mental Depression 4 | 333
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Myopia 4 | 176
Poor school performance 4 | 645
breast carcinoma 4 | 1,638
interstitial cystitis 4 | 2,312
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Attention deficit hyperactivity disorder 3 | 278
Brain Ischemia 3 | 110
Byzanthine arch palate 3 | 194
Carcinoma, Hepatocellular 3 | 228
Cocaine-Related Disorders 3 | 92
Concave bridge of nose 3 | 195
Congenital Epicanthus 3 | 177
Curvature of spine 3 | 282
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Down syndrome 3 | 499
Failure to gain weight 3 | 365
Heart disease 3 | 306
Liver carcinoma 3 | 240
Parkinson's disease 3 | 392
Pectus excavatum 3 | 100
Pediatric failure to thrive 3 | 365
Skin cancer 3 | 469
Ventricular Septal Defects 3 | 119
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
dermatomyositis 3 | 966
lung adenocarcinoma 3 | 2,716
pancreatic carcinoma 3 | 562

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Liver and Pancreas 31 | 16,750
Cardiovascular System 30 | 15,192

Target Family

Kinase 14 | 634
Non-IDG 13 | 12,091
Enzyme 5 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 32 | 32
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Phosphatidylinositol transfer protein alpha isoform PITPNA Tbio Non-IDG -1.53999 36.3 126
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Microtubule-associated protein 1B MAP1B Tchem Non-IDG -2.62090 412.6 168
Triple functional domain protein TRIO Tbio Kinase -2.04084 103.8 39
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452