Development Level

Tbio 35 | 11,445
Tchem 7 | 1,598
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 4 | 220
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased circulating triglyce... 2 | 42
increased startle reflex 2 | 112
abnormal bone mineralization 1 | 38
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal skin appearance 1 | 3
abnormal startle reflex 1 | 15
aorta stenosis 1 | 2
decreased caudal vertebrae num... 1 | 53
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
enlarged liver 1 | 2
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39

Disease

Carcinoma 43 | 11,493
osteosarcoma 29 | 7,950
glioblastoma 27 | 5,792
ovarian cancer 27 | 8,520
psoriasis 22 | 6,694
Cancer 19 | 2,499
ependymoma 19 | 4,679
Kidney cancer 18 | 2,613
atypical teratoid / rhabdoid tumor 18 | 5,112
medulloblastoma, large-cell 17 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
lung cancer 15 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Breast cancer 13 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
adult high grade glioma 12 | 3,801
diabetes mellitus 12 | 1,728
invasive ductal carcinoma 12 | 2,951
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
tuberculosis 11 | 2,010
Astrocytoma, Pilocytic 10 | 3,081
group 3 medulloblastoma 10 | 4,104
group 4 medulloblastoma 10 | 1,855
lung adenocarcinoma 10 | 2,716
primitive neuroectodermal tumor 10 | 3,035
Autosomal recessive predisposition 9 | 1,442
breast carcinoma 9 | 1,638
lung carcinoma 9 | 2,843
malignant mesothelioma 9 | 3,232
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
oligodendroglioma 8 | 2,850
Alzheimer's disease 7 | 658
Obesity 7 | 678
acute quadriplegic myopathy 7 | 1,158
colon cancer 7 | 1,478
juvenile dermatomyositis 7 | 1,187
ulcerative colitis 7 | 1,819
astrocytic glioma 6 | 2,597
dermatomyositis 6 | 966
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
subependymal giant cell astrocytoma 6 | 2,287
Gliosis 5 | 56
Kidney disease 5 | 430
Motor delay 5 | 147
Neoplasm Invasiveness 5 | 161
Neoplasm Metastasis 5 | 168
No development of motor milestones 5 | 147
Stomach Neoplasms 5 | 300
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
Adenoma 4 | 167
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Coronary artery disease 4 | 268
Diarrhea 4 | 253
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Dull intelligence 4 | 645
Heart failure 4 | 162
Hypertension 4 | 396
Hypertensive disease 4 | 292
Insulin Resistance 4 | 72
Intellectual disability 4 | 1,016
Liver cancer 4 | 604
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Poor school performance 4 | 645
Prenatal onset 4 | 139
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Vascular disease 4 | 319
fibroadenoma 4 | 559
pancreatic carcinoma 4 | 562
Arthritis 3 | 290
Cerebrovascular disease 3 | 238
Endometrial cancer 3 | 311
Endometriosis 3 | 540
Failure to gain weight 3 | 365
Heart disease 3 | 306
Liver Cirrhosis 3 | 181
Lung Neoplasms 3 | 232
Myopathy 3 | 185
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074

Tissue

Blood and immune system 47 | 16,909
Cardiovascular System 47 | 15,192
Digestive Tract 47 | 17,369
Endocrine System 47 | 18,159
Female tissues 47 | 17,400
Liver and Pancreas 47 | 16,750
Skin and soft tissues 47 | 17,230
Urinary Tract 47 | 16,678
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Respiratory system 46 | 16,393

Target Family

Non-IDG 34 | 12,091
Enzyme 7 | 4,145
GPCR 4 | 408
Kinase 2 | 634
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 ASAP2 Tbio Non-IDG -1.14527 15.1 71
Integrin alpha-7 ITGA7 Tbio Non-IDG -1.63563 42.4 193
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Integrin alpha-8 ITGA8 Tbio Non-IDG -1.36974 22.0 145
Carboxypeptidase E CPE Tbio Enzyme -3.01460 1019.8 229
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.99077 863.1 945
Secretory carrier-associated membrane protein 2 SCAMP2 Tbio Non-IDG -1.03513 11.2 191
Integrin alpha-4 ITGA4 Tclin Non-IDG -2.53262 310.4 1312
Exocyst complex component 4 EXOC4 Tbio Non-IDG -1.61492 39.1 121