Development Level

Tchem 22 | 1,598
Tbio 11 | 11,445
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased circulating creatini... 2 | 39
embryonic growth retardation 2 | 106
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased CD4-positive, alpha ... 1 | 4
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
small superior vagus ganglion 1 | 74

Disease

Cancer 31 | 2,499
Carcinoma 28 | 11,493
ovarian cancer 28 | 8,520
glioblastoma 23 | 5,792
lung cancer 19 | 4,740
psoriasis 19 | 6,694
osteosarcoma 18 | 7,950
atypical teratoid / rhabdoid tumor 17 | 5,112
adult high grade glioma 14 | 3,801
medulloblastoma, large-cell 14 | 6,241
Astrocytoma, Pilocytic 13 | 3,081
Arthritis 11 | 290
ependymoma 11 | 4,679
tuberculosis 11 | 2,010
Breast cancer 10 | 3,578
Kidney cancer 10 | 2,613
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Schizophrenia 9 | 1,160
group 3 medulloblastoma 9 | 4,104
interstitial cystitis 9 | 2,312
lung carcinoma 9 | 2,843
subependymal giant cell astrocytoma 9 | 2,287
Breast Neoplasms 8 | 445
Lung Neoplasms 8 | 232
Mammary Neoplasms 8 | 425
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
malignant mesothelioma 8 | 3,232
Autosomal recessive predisposition 7 | 1,442
Splenomegaly 7 | 190
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Failure to gain weight 6 | 365
Pediatric failure to thrive 6 | 365
breast carcinoma 6 | 1,638
group 4 medulloblastoma 6 | 1,855
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pituitary cancer 6 | 1,972
Agammaglobulinemia 5 | 34
Alzheimer's disease 5 | 658
Autoimmune lymphoproliferative syndrome 5 | 11
Bipolar Disorder 5 | 666
Cardiomyopathies 5 | 110
Cataract 5 | 297
Diffuse large B-cell lymphoma 5 | 39
Dull intelligence 5 | 645
Epilepsy 5 | 792
Fatigue 5 | 182
Hyperglycemia 5 | 137
Intellectual disability 5 | 1,016
Lens Opacities 5 | 231
Low intelligence 5 | 645
Lung disease 5 | 142
Lymphoma, Large B-Cell, Diffuse 5 | 34
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Obesity 5 | 678
Osteoporosis 5 | 363
Parkinson's disease 5 | 392
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
Short stature 5 | 531
Toxic encephalopathy 5 | 141
active Crohn's disease 5 | 922
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
primary Sjogren syndrome 5 | 735
Asthma 4 | 385
Disease Models, Animal 4 | 155
Fever 4 | 138
Heart disease 4 | 306
Hepatomegaly 4 | 285
Hypersensitivity reaction type II disease 4 | 253
Infantile onset 4 | 238
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Leukemia 4 | 104
Melanoma 4 | 711
Multiple Sclerosis 4 | 540
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Reperfusion Injury 4 | 86
Seizures 4 | 596
Sensorineural Hearing Loss (disorder) 4 | 284
Type 2 diabetes mellitus 4 | 272
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
lung adenocarcinoma 4 | 2,716
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074

Tissue

Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678

Target Family

Kinase 20 | 634
Non-IDG 11 | 12,091
Enzyme 5 | 4,145

PathwayCommons: pid Pathway

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http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Protein lifeguard 2 FAIM2 Tbio Non-IDG -2.37264 234.7 176
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.23001 181.6 129
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.62553 373.2 500
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351