Development Level

Tbio 38 | 11,445
Tchem 9 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 5 | 239
abnormal bone structure 3 | 187
increased mean corpuscular vol... 3 | 92
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cornea ulcer 1 | 1
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased heart rate variabili... 1 | 13
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
fused cornea and lens 1 | 5
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
iris synechia 1 | 3
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 36 | 11,493
ovarian cancer 36 | 8,520
group 3 medulloblastoma 29 | 4,104
osteosarcoma 29 | 7,950
psoriasis 26 | 6,694
lung cancer 25 | 4,740
Cancer 24 | 2,499
malignant mesothelioma 24 | 3,232
medulloblastoma, large-cell 23 | 6,241
Fanconi anemia 22 | 56
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 19 | 5,112
Breast cancer 17 | 3,578
Short stature 17 | 531
primitive neuroectodermal tumor 17 | 3,035
Anemia 16 | 365
Chromosome Breakage 16 | 36
Small head 16 | 374
non-small cell lung cancer 16 | 2,890
Dull intelligence 15 | 645
Intellectual disability 15 | 1,016
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Autosomal recessive predisposition 14 | 1,442
Increased chromosomal breakage 14 | 27
Esophageal atresia with or without tracheoesophageal fistula 13 | 21
ependymoma 13 | 4,679
esophageal atresia/tracheoesophageal fistula 13 | 22
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Decreased platelet count 12 | 111
Kidney cancer 12 | 2,613
Thrombocytopenia 12 | 197
ductal carcinoma in situ 12 | 1,745
invasive ductal carcinoma 12 | 2,951
Almond-shaped eyes 11 | 23
Ataxia telangiectasia 11 | 34
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Irregular hyperpigmentation 11 | 33
Leukopenia 11 | 72
Mental and motor retardation 11 | 608
Pyridoxine-responsive sideroblastic anemia 11 | 17
Radial aplasia/hypoplasia 11 | 29
Short palpebral fissure 11 | 38
hypopigmented skin patch 11 | 59
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Bloom syndrome 10 | 29
Esophageal atresia 10 | 43
Tracheoesophageal Fistula 10 | 36
adult high grade glioma 10 | 3,801
colon cancer 10 | 1,478
Breast Neoplasms 9 | 445
Fanconi Anemia, Complementation Group a 9 | 9
Mammary Neoplasms 9 | 425
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
Birthmark 8 | 35
Cafe-au-Lait Spots 8 | 37
Hemoglobin low 8 | 124
Nijmegen breakage syndrome 8 | 24
adrenocortical carcinoma 8 | 1,428
nasopharyngeal carcinoma 8 | 1,058
Hematologic Neoplasms 7 | 22
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Leukemia 7 | 104
Pick disease 7 | 1,894
Schizophrenia 7 | 1,160
Strabismus 7 | 270
Cryptorchidism 6 | 296
Pancytopenia 6 | 45
breast carcinoma 6 | 1,638
pancreatic cancer 6 | 2,398
Absence of radius and ulna 5 | 15
Absent radius 5 | 15
Atopic dermatitis 5 | 952
Congenital absence of kidney 5 | 31
Endometriosis 5 | 540
Hypoplasia of thumb 5 | 26
Malignant neoplasm of breast 5 | 15
Microcephaly 5 | 166
Neutrophil count decreased 5 | 47
Prostatic Neoplasms 5 | 495
Radial aplasia 5 | 15
Seckel syndrome 5 | 34
Thumb aplasia 5 | 16
Waldenstrons macroglobulinemia 5 | 765
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group F 5 | 22
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung carcinoma 5 | 2,843
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 47 | 15,192

Target Family

Non-IDG 38 | 12,091
Enzyme 5 | 4,145
Kinase 3 | 634
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
Fanconi-associated nuclease 1 FAN1 Tbio Enzyme -2.06970 115.9 85
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Fanconi anemia group C protein FANCC Tbio Non-IDG -2.85516 703.4 348
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Fanconi anemia group B protein FANCB Tbio Non-IDG -2.33079 210.0 96