Development Level

Tbio 30 | 11,445
Tchem 8 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 2 | 239
increased circulating chloride... 2 | 41
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
excessive tearing 1 | 2
fusion of vertebral arches 1 | 7
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased granulocyte number 1 | 1
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 31 | 8,520
Carcinoma 30 | 11,493
atypical teratoid / rhabdoid tumor 26 | 5,112
lung cancer 26 | 4,740
medulloblastoma, large-cell 25 | 6,241
glioblastoma 24 | 5,792
group 3 medulloblastoma 24 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
primitive neuroectodermal tumor 23 | 3,035
Breast cancer 22 | 3,578
adult high grade glioma 22 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
non-small cell lung cancer 22 | 2,890
psoriasis 22 | 6,694
ependymoma 20 | 4,679
lung adenocarcinoma 20 | 2,716
adrenocortical carcinoma 19 | 1,428
malignant mesothelioma 18 | 3,232
Cancer 17 | 2,499
breast carcinoma 17 | 1,638
osteosarcoma 17 | 7,950
pancreatic cancer 17 | 2,398
colon cancer 15 | 1,478
ductal carcinoma in situ 14 | 1,745
Atopic dermatitis 13 | 952
Endometriosis 11 | 540
nasopharyngeal carcinoma 11 | 1,058
Kidney cancer 9 | 2,613
oligodendroglioma 9 | 2,850
Multiple myeloma 8 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
Astrocytoma, Pilocytic 6 | 3,081
Mammary Neoplasms, Experimental 6 | 154
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
pancreatic carcinoma 6 | 562
primary Sjogren syndrome 6 | 735
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Animal Mammary Neoplasms 5 | 136
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
Mammary Neoplasms, Animal 5 | 136
Renal Cell Carcinoma 5 | 214
Stomach Neoplasms 5 | 300
Waldenstrons macroglobulinemia 5 | 765
astrocytic glioma 5 | 2,597
Disease Models, Animal 4 | 155
Melanoma 4 | 711
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
acute quadriplegic myopathy 4 | 1,158
cystic fibrosis 4 | 1,696
hepatocellular carcinoma 4 | 547
mucosa-associated lymphoid tissue lymphoma 4 | 484
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis 4 | 2,010
tuberculosis and treatment for 6 months 4 | 409
Adenocarcinoma of lung 3 | 142
Autosomal recessive predisposition 3 | 1,442
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Duchenne muscular dystrophy 3 | 601
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Neoplasm Invasiveness 3 | 161
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
diabetes mellitus 3 | 1,728
non-small cell lung carcinoma 3 | 317
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
Attention deficit hyperactivity disorder 2 | 278
Chronic Lymphocytic Leukemia 2 | 262
Congenital Epicanthus 2 | 177
Down syndrome 2 | 499
Glaucoma 2 | 239
Hypertension 2 | 396
Male infertility 2 | 206
Myocardial Ischemia 2 | 169
Polycystic ovary syndrome 2 | 360
Strabismus 2 | 270
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
fibroadenoma 2 | 559
juvenile dermatomyositis 2 | 1,187
spina bifida 2 | 1,074

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Non-IDG 27 | 12,091
Enzyme 7 | 4,145
Kinase 5 | 634
Epigenetic 1 | 242

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Vimentin VIM Tbio Non-IDG -3.27433 1830.9 2236
Cullin-3 CUL3 Tbio Non-IDG -3.26322 1670.8 307
Nucleophosmin NPM1 Tbio Non-IDG -3.12496 1315.8 912
Aurora kinase A AURKA Tchem Kinase -3.08347 1158.0 702
Stathmin STMN1 Tbio Non-IDG -2.90296 824.2 1052
Aurora kinase B AURKB Tchem Kinase -2.91521 803.4 692
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Nucleolin NCL Tbio Non-IDG -2.84337 683.3 487
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.73322 567.0 386