Development Level

Tbio 34 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
edema 2 | 59
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent teeth 1 | 3
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39

Disease

Carcinoma 32 | 11,493
osteosarcoma 30 | 7,950
ovarian cancer 29 | 8,520
glioblastoma 23 | 5,792
Cancer 21 | 2,499
psoriasis 21 | 6,694
atypical teratoid / rhabdoid tumor 20 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
lung cancer 18 | 4,740
ependymoma 17 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
medulloblastoma, large-cell 17 | 6,241
pancreatic cancer 15 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Astrocytoma, Pilocytic 13 | 3,081
Breast cancer 13 | 3,578
Kidney cancer 13 | 2,613
malignant mesothelioma 12 | 3,232
oligodendroglioma 12 | 2,850
astrocytic glioma 11 | 2,597
group 4 medulloblastoma 11 | 1,855
interstitial cystitis 11 | 2,312
primitive neuroectodermal tumor 11 | 3,035
acute quadriplegic myopathy 10 | 1,158
adult high grade glioma 10 | 3,801
lung carcinoma 10 | 2,843
invasive ductal carcinoma 9 | 2,951
non-small cell lung cancer 9 | 2,890
Autosomal recessive predisposition 8 | 1,442
Kidney disease 8 | 430
Neoplasm Invasiveness 8 | 161
breast carcinoma 8 | 1,638
group 3 medulloblastoma 8 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Neoplasm Metastasis 7 | 168
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
juvenile dermatomyositis 7 | 1,187
pediatric high grade glioma 7 | 1,064
pituitary cancer 7 | 1,972
spina bifida 7 | 1,074
Carcinoma, Hepatocellular 6 | 228
Liver Cirrhosis, Experimental 6 | 769
Liver carcinoma 6 | 240
Pick disease 6 | 1,894
adrenocortical carcinoma 6 | 1,428
gastric carcinoma 6 | 807
lung adenocarcinoma 6 | 2,716
ulcerative colitis 6 | 1,819
Alzheimer's disease 5 | 658
Bladder Neoplasm 5 | 112
Carcinoma, Squamous Cell 5 | 110
Disease Progression 5 | 136
Leukemia, Myelocytic, Acute 5 | 120
Liver cancer 5 | 604
Ovarian Neoplasms 5 | 102
Prostatic Neoplasms 5 | 495
Squamous cell carcinoma 5 | 129
Stomach Neoplasms 5 | 300
Urinary Bladder Neoplasms 5 | 114
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
colon cancer 5 | 1,478
dermatomyositis 5 | 966
ovarian neoplasm 5 | 99
Adenocarcinoma 4 | 122
Adenoma 4 | 167
Cell Transformation, Neoplastic 4 | 97
Intellectual disability 4 | 1,016
Leukemia, Myeloid, Acute 4 | 105
Liver Neoplasms, Experimental 4 | 59
Liver disease 4 | 237
Lung disease 4 | 142
Mesothelioma, Malignant 4 | 105
Multiple myeloma 4 | 1,332
Nonsyndromic deafness 4 | 142
Obesity 4 | 678
Pulmonary Fibrosis 4 | 106
Small head 4 | 374
cystic fibrosis 4 | 1,696
medulloblastoma 4 | 720
pancreatic carcinoma 4 | 562
Arthritis, Juvenile 3 | 126
Endometriosis 3 | 540
Hypertension 3 | 396
Juvenile arthritis 3 | 126
Schizophrenia 3 | 1,160
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 665
cutaneous lupus erythematosus 3 | 1,057
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 547
mucosa-associated lymphoid tissue lymphoma 3 | 484
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 41 | 15,192
Respiratory system 41 | 16,393

Target Family

Non-IDG 31 | 12,091
Kinase 7 | 634
Enzyme 5 | 4,145

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
LIM domain and actin-binding protein 1 LIMA1 Tbio Non-IDG -1.26880 23.6 187
ARF GTPase-activating protein GIT1 GIT1 Tbio Enzyme -1.84352 75.7 358
Lipoma-preferred partner LPP Tbio Non-IDG -2.77949 582.6 164
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Kinesin-like protein KIFC3 KIFC3 Tbio Non-IDG -1.14031 12.8 56
Abl interactor 1 ABI1 Tbio Non-IDG -1.99953 104.1 264
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase MGAT3 Tchem Enzyme -1.26703 17.3 170
Exocyst complex component 4 EXOC4 Tbio Non-IDG -1.61492 39.1 121
Pleckstrin homology domain-containing family A member 7 PLEKHA7 Tbio Non-IDG -0.97160 13.3 46
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982