Development Level

Tbio 45 | 11,651
Tchem 10 | 1,388
Tclin 7 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased bone mineral density 3 | 126
decreased erythrocyte cell num... 3 | 62
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
preweaning lethality, incomple... 3 | 499
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
decreased body length 2 | 101
decreased body weight 2 | 161
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
thrombocytopenia 2 | 56
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39

Disease

Cancer 47 | 2,499
psoriasis 42 | 6,694
Carcinoma 40 | 11,493
osteosarcoma 38 | 7,950
ovarian cancer 38 | 8,520
glioblastoma 34 | 5,792
lung cancer 31 | 4,740
group 3 medulloblastoma 28 | 4,104
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 25 | 5,112
malignant mesothelioma 24 | 3,232
Breast cancer 23 | 3,578
subependymal giant cell astrocytoma 23 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
non-small cell lung cancer 20 | 2,890
ependymoma 18 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
invasive ductal carcinoma 16 | 2,951
primitive neuroectodermal tumor 16 | 3,035
ulcerative colitis 16 | 1,819
Astrocytoma, Pilocytic 15 | 3,081
cystic fibrosis 15 | 1,696
ductal carcinoma in situ 15 | 1,745
pancreatic cancer 15 | 2,398
Kidney cancer 14 | 2,613
Liver Cirrhosis, Experimental 14 | 769
adult high grade glioma 14 | 3,801
interstitial cystitis 14 | 2,312
lung adenocarcinoma 14 | 2,716
acute quadriplegic myopathy 13 | 1,158
colon cancer 13 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
juvenile dermatomyositis 13 | 1,187
lung carcinoma 13 | 2,843
pituitary cancer 13 | 1,972
Schizophrenia 12 | 1,160
astrocytoma 12 | 1,146
dermatomyositis 12 | 966
diabetes mellitus 12 | 1,728
tuberculosis 12 | 2,010
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
Prostatic Neoplasms 11 | 495
nasopharyngeal carcinoma 11 | 1,058
oligodendroglioma 11 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Multiple myeloma 10 | 1,332
astrocytic glioma 10 | 2,597
breast carcinoma 10 | 1,638
primary pancreatic ductal adenocarcinoma 10 | 1,109
Lung Neoplasms 9 | 232
Stomach Neoplasms 9 | 300
Adenoma 8 | 167
Leukemia, Myelocytic, Acute 8 | 120
Leukemia, Myeloid, Acute 8 | 105
Multiple Sclerosis 8 | 540
Pick disease 8 | 1,894
Waldenstrons macroglobulinemia 8 | 765
acute myeloid leukemia 8 | 783
adrenocortical carcinoma 8 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
group 4 medulloblastoma 8 | 1,855
pediatric high grade glioma 8 | 1,064
Autosomal recessive predisposition 7 | 1,442
Bipolar Disorder 7 | 666
Carcinoma, Squamous Cell 7 | 110
Colonic Neoplasms 7 | 142
Depressive disorder 7 | 409
Duchenne muscular dystrophy 7 | 601
Epilepsy 7 | 792
Lymphoid leukemia 7 | 160
Obesity 7 | 678
Seizures 7 | 596
Squamous cell carcinoma 7 | 129
Vascular disease 7 | 319
cutaneous lupus erythematosus 7 | 1,057
esophageal adenocarcinoma 7 | 737
non primary Sjogren syndrome sicca 7 | 891
Alzheimer's disease 6 | 658
Amyotrophic lateral sclerosis 6 | 451
Carcinoma, Non-Small-Cell Lung 6 | 107
Cell Transformation, Neoplastic 6 | 97
Down syndrome 6 | 499
Immune system cancer 6 | 140
Neoplastic Cell Transformation 6 | 89
Pancreatic Neoplasm 6 | 85
Pancreatic Neoplasms 6 | 85
Arthritis, Juvenile 5 | 126
Crohn's disease 5 | 321
Failure to gain weight 5 | 365
Juvenile arthritis 5 | 126
Kidney disease 5 | 430
Pediatric failure to thrive 5 | 365
Rheumatoid arthritis 5 | 1,191
active ulcerative colitis 5 | 764
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 559
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
urothelial carcinoma 5 | 318

Tissue

Blood and immune system 63 | 16,909
Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 62 | 17,400
Liver and Pancreas 62 | 16,750
Male tissues 62 | 17,142
Respiratory system 62 | 16,393
Skin and soft tissues 62 | 17,230
Urinary Tract 62 | 16,678
Nervous System 61 | 16,725
Cardiovascular System 60 | 15,192

Target Family

Non-IDG 28 | 12,091
Transcription Factor 21 | 1,400
Enzyme 7 | 4,145
Epigenetic 4 | 242
Kinase 2 | 634
Transporter 1 | 473

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 63 | 63
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.57508 40.4 92
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
Protein NDRG2 NDRG2 Tbio Non-IDG -1.94343 142.1 289
Nuclear transcription factor Y subunit gamma NFYC Tbio Transcription Factor -1.89858 75.4 191
Sideroflexin-3 SFXN3 Tdark Non-IDG -0.50060 3.38 107
Dickkopf-related protein 1 DKK1 Tchem Non-IDG -2.79271 621.8 694
Protein max MAX Tbio Transcription Factor -2.14268 110.6 398
Ferritin heavy chain FTH1 Tbio Non-IDG -3.00480 982.1 562
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859