Development Level

Tclin 10 | 613
Tchem 9 | 1,598
Tbio 7 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
increased blood urea nitrogen ... 2 | 48
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
decreased circulating bilirubi... 1 | 19
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Cancer 23 | 2,499
Carcinoma 19 | 11,493
osteosarcoma 18 | 7,950
ovarian cancer 17 | 8,520
glioblastoma 15 | 5,792
Breast cancer 14 | 3,578
lung cancer 12 | 4,740
Liver Cirrhosis, Experimental 11 | 769
diabetes mellitus 11 | 1,728
non-small cell lung cancer 11 | 2,890
pancreatic cancer 11 | 2,398
psoriasis 11 | 6,694
Heart disease 10 | 306
Schizophrenia 10 | 1,160
cystic fibrosis 10 | 1,696
ependymoma 10 | 4,679
Kidney cancer 9 | 2,613
interstitial cystitis 9 | 2,312
invasive ductal carcinoma 9 | 2,951
medulloblastoma, large-cell 9 | 6,241
Astrocytoma, Pilocytic 8 | 3,081
Bipolar Disorder 8 | 666
Blastic phase chronic myeloid leukemia 8 | 58
Chronic Myelocytic Leukemia Accelerated Phase 8 | 59
Coronary artery disease 8 | 268
Depressive disorder 8 | 409
Kidney disease 8 | 430
adult high grade glioma 8 | 3,801
ulcerative colitis 8 | 1,819
atypical teratoid / rhabdoid tumor 7 | 5,112
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
Alzheimer's disease 6 | 658
Chronic phase chronic myeloid leukemia 6 | 45
Cleft Palate 6 | 271
Hypertension 6 | 396
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 6 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 6 | 47
astrocytic glioma 6 | 2,597
dermatomyositis 6 | 966
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
tuberculosis 6 | 2,010
Arthritis 5 | 290
Cardiomegaly 5 | 116
Cerebrovascular disease 5 | 238
Colorectal Neoplasms 5 | 243
Craniosynostosis 5 | 74
Liver Cirrhosis 5 | 181
Lung disease 5 | 142
Pulmonary Fibrosis 5 | 106
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 764
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
Aortic Valve Insufficiency 4 | 40
Atherosclerosis 4 | 291
Breast Neoplasms 4 | 445
Byzanthine arch palate 4 | 194
Cerebral Hemorrhage 4 | 42
Chronic Lymphocytic Leukemia 4 | 262
Down syndrome 4 | 499
Exophthalmos 4 | 112
Gastrointestinal system disease 4 | 54
Hypertensive disease 4 | 292
Loeys-Dietz syndrome 4 | 23
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
Melanoma 4 | 711
Mental Depression 4 | 333
Neoplasm Metastasis 4 | 168
Orbital separation excessive 4 | 244
Osteoporosis 4 | 363
Prominent eyes 4 | 96
Prominent globes 4 | 96
Prostatic Neoplasms 4 | 495
Protruding eyes 4 | 96
Renal Cell Carcinoma 4 | 214
Seizures 4 | 596
Squamous cell carcinoma 4 | 129
Toxic encephalopathy 4 | 141
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
gastric carcinoma 4 | 807
mucosa-associated lymphoid tissue lymphoma 4 | 484
nephrosclerosis 4 | 333
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Hypersensitivity reaction type II disease 3 | 253

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 24 | 15,192

Target Family

Kinase 12 | 634
Non-IDG 12 | 12,091
Enzyme 1 | 4,145
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Phospholipase A2, membrane associated PLA2G2A Tchem Enzyme -2.83666 743.3 137
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Tyrosine-protein kinase Fgr FGR Tchem Kinase -2.37977 226.9 400
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Major prion protein PRNP Tchem Non-IDG -3.45326 5611.1 484
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548