Development Level

Tbio 19 | 11,445
Tchem 17 | 1,598
Tclin 17 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased leukocyte cell numbe... 3 | 73
abnormal behavior 2 | 298
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
decreased lymphocyte cell numb... 2 | 83
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
thrombocytopenia 2 | 56
abnormal femur morphology 1 | 14
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal testis morphology 1 | 43
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged liver 1 | 2
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39
trunk curl 1 | 16

Disease

Cancer 47 | 2,499
Carcinoma 42 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 31 | 7,950
diabetes mellitus 23 | 1,728
glioblastoma 23 | 5,792
psoriasis 23 | 6,694
Breast cancer 21 | 3,578
lung cancer 21 | 4,740
invasive ductal carcinoma 20 | 2,951
medulloblastoma, large-cell 19 | 6,241
interstitial cystitis 17 | 2,312
pancreatic cancer 17 | 2,398
Kidney cancer 16 | 2,613
Liver Cirrhosis, Experimental 16 | 769
Breast Neoplasms 15 | 445
atypical teratoid / rhabdoid tumor 15 | 5,112
malignant mesothelioma 15 | 3,232
Mammary Neoplasms 14 | 425
Obesity 14 | 678
Schizophrenia 13 | 1,160
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Arthritis 12 | 290
Kidney disease 12 | 430
ductal carcinoma in situ 12 | 1,745
lung carcinoma 12 | 2,843
Atherosclerosis 11 | 291
Autosomal recessive predisposition 11 | 1,442
Blastic phase chronic myeloid leukemia 11 | 58
Chronic Myelocytic Leukemia Accelerated Phase 11 | 59
Heart disease 11 | 306
Prostatic Neoplasms 11 | 495
pituitary cancer 11 | 1,972
tuberculosis 11 | 2,010
Anemia 10 | 365
Astrocytoma, Pilocytic 10 | 3,081
Hyperglycemia 10 | 137
Hypertension 10 | 396
Rheumatoid arthritis 10 | 1,191
adult high grade glioma 10 | 3,801
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
ependymoma 10 | 4,679
juvenile dermatomyositis 10 | 1,187
non-small cell lung cancer 10 | 2,890
pancreatic carcinoma 10 | 562
primary pancreatic ductal adenocarcinoma 10 | 1,109
Chronic phase chronic myeloid leukemia 9 | 45
Insulin Resistance 9 | 72
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 9 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 9 | 47
Stomach Neoplasms 9 | 300
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
ulcerative colitis 9 | 1,819
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Hyperinsulinism 8 | 133
adrenocortical carcinoma 8 | 1,428
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Adenocarcinoma 7 | 122
Animal Mammary Neoplasms 7 | 136
Cerebrovascular disease 7 | 238
Coronary artery disease 7 | 268
Depressive disorder 7 | 409
Lung Neoplasms 7 | 232
Mammary Neoplasms, Animal 7 | 136
Mammary Neoplasms, Experimental 7 | 154
Neoplasm Invasiveness 7 | 161
Neoplasm Metastasis 7 | 168
Osteoporosis 7 | 363
Polycystic ovary syndrome 7 | 360
Thrombocytopenia 7 | 197
astrocytoma 7 | 1,146
cutaneous lupus erythematosus 7 | 1,057
subependymal giant cell astrocytoma 7 | 2,287
Adenoma 6 | 167
Alzheimer's disease 6 | 658
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Carcinoma, Hepatocellular 6 | 228
Colonic Neoplasms 6 | 142
Crohn's disease 6 | 321
Diabetes Mellitus, Type 2 6 | 142
Hypertensive disease 6 | 292
Hypothyroidism 6 | 122
Immune system cancer 6 | 140
Liver carcinoma 6 | 240
Liver disease 6 | 237
Lung disease 6 | 142
Multiple myeloma 6 | 1,332
Polycythemia vera 6 | 27
Seizures 6 | 596
Vascular disease 6 | 319
astrocytic glioma 6 | 2,597
gastric carcinoma 6 | 807
oligodendroglioma 6 | 2,850
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735

Tissue

Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Skin and soft tissues 53 | 17,230
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Urinary Tract 52 | 16,678
Blood and immune system 51 | 16,909
Cardiovascular System 51 | 15,192
Nervous System 51 | 16,725
Respiratory system 51 | 16,393

Target Family

Non-IDG 24 | 12,091
Kinase 20 | 634
Enzyme 4 | 4,145
Transcription Factor 4 | 1,400
Ion Channel 1 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Cadherin-2 CDH2 Tbio Non-IDG -3.19431 1382.9 993
Transient receptor potential cation channel subfamily V member 6 TRPV6 Tchem Ion Channel -2.38299 247.1 126
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Integrin alpha-IIb ITGA2B Tclin Non-IDG -3.52120 3309.8 1170
Tyrosine-protein kinase Fgr FGR Tchem Kinase -2.37977 226.9 400
Macrophage colony-stimulating factor 1 receptor CSF1R Tclin Kinase -3.19109 1432.9 1169