Development Level

Tbio 36 | 11,445
Tchem 33 | 1,598
Tclin 4 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 4 | 979
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal vibrissa morphology 2 | 25
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal limb morphology 1 | 13
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
absent spleen 1 | 3
absent testes 1 | 6
brachydactyly 1 | 19
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
edema 1 | 59
enlarged urinary bladder 1 | 8
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
premature death 1 | 5
respiratory system phenotype 1 | 2
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 50 | 11,493
ovarian cancer 47 | 8,520
Cancer 44 | 2,499
glioblastoma 37 | 5,792
psoriasis 34 | 6,694
osteosarcoma 33 | 7,950
medulloblastoma, large-cell 32 | 6,241
atypical teratoid / rhabdoid tumor 30 | 5,112
ependymoma 29 | 4,679
malignant mesothelioma 22 | 3,232
Alzheimer's disease 20 | 658
adult high grade glioma 20 | 3,801
lung cancer 20 | 4,740
Astrocytoma, Pilocytic 19 | 3,081
Schizophrenia 18 | 1,160
diabetes mellitus 17 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
oligodendroglioma 17 | 2,850
subependymal giant cell astrocytoma 17 | 2,287
Breast cancer 15 | 3,578
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
invasive ductal carcinoma 15 | 2,951
primitive neuroectodermal tumor 15 | 3,035
tuberculosis 15 | 2,010
astrocytoma 14 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
pancreatic cancer 14 | 2,398
Bipolar Disorder 13 | 666
Toxic encephalopathy 13 | 141
astrocytic glioma 13 | 2,597
group 4 medulloblastoma 13 | 1,855
non-small cell lung cancer 13 | 2,890
Neurodegenerative disease 12 | 414
lung carcinoma 12 | 2,843
Depressive disorder 11 | 409
Kidney cancer 11 | 2,613
Parkinson's disease 11 | 392
lung adenocarcinoma 11 | 2,716
pediatric high grade glioma 11 | 1,064
ulcerative colitis 11 | 1,819
Amyotrophic lateral sclerosis 10 | 451
Autosomal recessive predisposition 10 | 1,442
Cerebrovascular disease 10 | 238
Intellectual disability 10 | 1,016
Neuropathy 10 | 261
Prostatic Neoplasms 10 | 495
Seizures 10 | 596
Arthritis 9 | 290
Brain Ischemia 9 | 110
Brain disease 9 | 96
Down syndrome 9 | 499
Epilepsy 9 | 792
Mental Depression 9 | 333
Nerve Degeneration 9 | 121
Pick disease 9 | 1,894
Rheumatoid arthritis 9 | 1,191
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,187
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Multiple Sclerosis 8 | 540
Obesity 8 | 678
Poor school performance 8 | 645
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
Asthma 7 | 385
Breast Neoplasms 7 | 445
Hypersensitivity reaction type II disease 7 | 253
Kidney disease 7 | 430
Mammary Neoplasms 7 | 425
Multiple myeloma 7 | 1,332
Neoplasm Metastasis 7 | 168
colon cancer 7 | 1,478
hepatocellular carcinoma 7 | 547
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Endometriosis 6 | 540
Eye disease 6 | 62
Heart disease 6 | 306
Huntington's disease 6 | 76
Hypertension 6 | 396
Infantile onset 6 | 238
Inflammatory bowel disease 6 | 151
Leukemia 6 | 104
Liver Cirrhosis, Experimental 6 | 769
Lung disease 6 | 142
Splenomegaly 6 | 190
acute quadriplegic myopathy 6 | 1,158
dermatomyositis 6 | 966
interstitial cystitis 6 | 2,312
pancreatic carcinoma 6 | 562

Tissue

Digestive Tract 74 | 17,369
Endocrine System 74 | 18,159
Nervous System 74 | 16,725
Blood and immune system 73 | 16,909
Female tissues 73 | 17,400
Male tissues 73 | 17,142
Respiratory system 73 | 16,393
Skin and soft tissues 73 | 17,230
Urinary Tract 73 | 16,678
Liver and Pancreas 72 | 16,750
Cardiovascular System 70 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 20 | 4,145
Kinase 15 | 634
Transcription Factor 4 | 1,400
GPCR 1 | 408
TF/Epigenetic 1 | 38

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.89 89
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Protein BEX1 BEX1 Tbio Non-IDG -1.32314 23.8 124
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Rho GDP-dissociation inhibitor 1 ARHGDIA Tchem Non-IDG -2.56885 370.1 382
Protein BEX3 BEX3 Tbio Non-IDG -1.94670 88.1 199
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833