Development Level

Tchem 24 | 1,598
Tbio 19 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
decreased circulating sodium l... 2 | 22
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased leukocyte cell numbe... 2 | 47
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased thermal nociceptive ... 1 | 9
premature death 1 | 5
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 35 | 8,520
Cancer 34 | 2,499
Carcinoma 34 | 11,493
glioblastoma 29 | 5,792
psoriasis 26 | 6,694
lung cancer 23 | 4,740
osteosarcoma 22 | 7,950
ependymoma 21 | 4,679
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 17 | 3,232
medulloblastoma, large-cell 16 | 6,241
oligodendroglioma 16 | 2,850
Schizophrenia 14 | 1,160
Astrocytoma, Pilocytic 13 | 3,081
Breast Neoplasms 13 | 445
Breast cancer 13 | 3,578
Mammary Neoplasms 13 | 425
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Prostatic Neoplasms 12 | 495
Vascular disease 12 | 319
adult high grade glioma 12 | 3,801
astrocytic glioma 12 | 2,597
Autosomal recessive predisposition 11 | 1,442
Intellectual disability 11 | 1,016
group 3 medulloblastoma 11 | 4,104
lung carcinoma 11 | 2,843
subependymal giant cell astrocytoma 11 | 2,287
Alzheimer's disease 10 | 658
Bipolar Disorder 10 | 666
Brain Ischemia 10 | 110
Dull intelligence 10 | 645
Liver Cirrhosis, Experimental 10 | 769
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
tuberculosis 10 | 2,010
Kidney cancer 9 | 2,613
Lung Neoplasms 9 | 232
Multiple myeloma 9 | 1,332
Short stature 9 | 531
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Arthritis 8 | 290
Carcinoma, Hepatocellular 8 | 228
Diabetes Mellitus, Experimental 8 | 108
Kidney disease 8 | 430
Liver carcinoma 8 | 240
Neoplasm Invasiveness 8 | 161
Neoplasm Metastasis 8 | 168
Pick disease 8 | 1,894
Splenomegaly 8 | 190
Stomach Neoplasms 8 | 300
Adenocarcinoma 7 | 122
Asthma 7 | 385
Depressive disorder 7 | 409
Heart disease 7 | 306
Hyperalgesia 7 | 83
Inflammatory bowel disease 7 | 151
Lung disease 7 | 142
Neurodegenerative disease 7 | 414
Obesity 7 | 678
Osteoporosis 7 | 363
Reperfusion Injury 7 | 86
acute myeloid leukemia 7 | 783
cystic fibrosis 7 | 1,696
interstitial cystitis 7 | 2,312
Acquired scoliosis 6 | 281
Blepharoptosis 6 | 231
Cognitive delay 6 | 608
Colonic Neoplasms 6 | 142
Curvature of spine 6 | 282
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Diabetes Mellitus, Type 2 6 | 142
Disease Models, Animal 6 | 155
Global developmental delay 6 | 608
Hypertension 6 | 396
Leukemia 6 | 104
Liver Neoplasms, Experimental 6 | 59
Mental Depression 6 | 333
Mental and motor retardation 6 | 608
Neoplastic Cell Transformation 6 | 89
Nerve Degeneration 6 | 121
Parkinson's disease 6 | 392
Polycystic ovary syndrome 6 | 360
Renal Cell Carcinoma 6 | 214
Toxic encephalopathy 6 | 141
acute quadriplegic myopathy 6 | 1,158
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
dermatomyositis 6 | 966
hepatocellular carcinoma 6 | 547
invasive ductal carcinoma 6 | 2,951
juvenile dermatomyositis 6 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary Sjogren syndrome 6 | 735

Tissue

Blood and immune system 49 | 16,909
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 22 | 12,091
Kinase 18 | 634
Enzyme 6 | 4,145
Transcription Factor 3 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 49 | 49
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-activating death domain protein MADD Tbio Enzyme -1.86555 79.6 121
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
Death domain-containing protein CRADD CRADD Tbio Non-IDG -1.34614 23.0 400
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Eukaryotic translation initiation factor 2A EIF2A Tbio Non-IDG -0.62095 4.12 272
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
PRKC apoptosis WT1 regulator protein PAWR Tbio Non-IDG -1.93678 105.8 292
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Interferon-inducible double-stranded RNA-dependent protein kinase activator A PRKRA Tbio Kinase -1.51727 34.3 299