Development Level

Tbio 34 | 11,445
Tchem 20 | 1,598

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased circulating fructosa... 3 | 30
abnormal bone structure 2 | 187
abnormal startle reflex 2 | 15
decreased bone mineral content 2 | 151
decreased circulating insulin ... 2 | 76
decreased total body fat amoun... 2 | 207
edema 2 | 59
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased mean corpuscular vol... 2 | 92
persistence of hyaloid vascula... 2 | 33
preweaning lethality, incomple... 2 | 499
small testis 2 | 58
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal hair texture 1 | 4
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
absent urinary bladder 1 | 1
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
embryonic growth retardation 1 | 106
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
short tibia 1 | 97
stereotypic behavior 1 | 3
thrombocytopenia 1 | 56
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

osteosarcoma 39 | 7,950
Carcinoma 37 | 11,493
ovarian cancer 37 | 8,520
glioblastoma 35 | 5,792
atypical teratoid / rhabdoid tumor 29 | 5,112
medulloblastoma, large-cell 29 | 6,241
psoriasis 26 | 6,694
Cancer 23 | 2,499
lung cancer 23 | 4,740
adult high grade glioma 22 | 3,801
Breast cancer 21 | 3,578
ependymoma 20 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Astrocytoma, Pilocytic 18 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
pancreatic cancer 16 | 2,398
primitive neuroectodermal tumor 16 | 3,035
invasive ductal carcinoma 15 | 2,951
diabetes mellitus 14 | 1,728
group 4 medulloblastoma 14 | 1,855
non-small cell lung cancer 14 | 2,890
tuberculosis 13 | 2,010
lung carcinoma 12 | 2,843
subependymal giant cell astrocytoma 12 | 2,287
Kidney cancer 11 | 2,613
Waldenstrons macroglobulinemia 11 | 765
juvenile dermatomyositis 11 | 1,187
Breast Neoplasms 10 | 445
Kidney disease 10 | 430
Mammary Neoplasms 10 | 425
breast carcinoma 10 | 1,638
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
oligodendroglioma 10 | 2,850
Rheumatoid arthritis 9 | 1,191
astrocytic glioma 9 | 2,597
group 3 medulloblastoma 9 | 4,104
Schizophrenia 8 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pediatric high grade glioma 8 | 1,064
pituitary cancer 8 | 1,972
primary pancreatic ductal adenocarcinoma 8 | 1,109
ulcerative colitis 8 | 1,819
Alzheimer's disease 7 | 658
Multiple myeloma 7 | 1,332
Neoplasm Metastasis 7 | 168
Obesity 7 | 678
Pick disease 7 | 1,894
Precancerous Conditions 7 | 80
Vascular disease 7 | 319
acute quadriplegic myopathy 7 | 1,158
interstitial cystitis 7 | 2,312
primary Sjogren syndrome 7 | 735
Atherosclerosis 6 | 291
Cell Transformation, Neoplastic 6 | 97
Neoplastic Cell Transformation 6 | 89
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
ductal carcinoma in situ 6 | 1,745
Arthritis 5 | 290
Colonic Neoplasms 5 | 142
Duchenne muscular dystrophy 5 | 601
Hypertension 5 | 396
Inflammatory bowel disease 5 | 151
Lung Neoplasms 5 | 232
Parkinson's disease 5 | 392
Proteinuria 5 | 144
Reperfusion Injury 5 | 86
Stomach Neoplasms 5 | 300
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
colon cancer 5 | 1,478
esophageal adenocarcinoma 5 | 737
gastric cancer 5 | 459
medulloblastoma 5 | 720
Amyotrophic lateral sclerosis 4 | 451
Atopic dermatitis 4 | 952
Attention deficit hyperactivity disorder 4 | 278
Brain Ischemia 4 | 110
Carcinoma, Hepatocellular 4 | 228
Depressive disorder 4 | 409
Endometriosis 4 | 540
Eye disease 4 | 62
Heart disease 4 | 306
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Liver neoplasms 4 | 130
Lung disease 4 | 142
Malabsorption 4 | 82
Neoplasm Invasiveness 4 | 161
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Toxic encephalopathy 4 | 141
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 25 | 12,091
Kinase 15 | 634
Enzyme 9 | 4,145
Transcription Factor 4 | 1,400
Ion Channel 1 | 344

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 54 | 54
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
http://pathwaycommons.org/pc2/... 102 | 102
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
Actin-related protein 2 ACTR2 Tbio Non-IDG -1.88412 78.5 211
Rho GDP-dissociation inhibitor 1 ARHGDIA Tchem Non-IDG -2.56885 370.1 382
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.90666 762.6 254
Abl interactor 1 ABI1 Tbio Non-IDG -1.99953 104.1 264
Actin-related protein 2/3 complex subunit 2 ARPC2 Tbio Non-IDG -1.31089 16.9 270
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Actin-related protein 2/3 complex subunit 4 ARPC4 Tbio Non-IDG -1.00650 0.00000 120
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513