Development Level

Tbio 36 | 11,445
Tchem 28 | 1,598
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
decreased circulating fructosa... 3 | 30
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
abnormal startle reflex 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal coping response 1 | 1
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal digestive system phys... 1 | 1
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
fusion of vertebral arches 1 | 7
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased vertical activity 1 | 24
long tibia 1 | 25
mammalian phenotype 1 | 17
pallor 1 | 34
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 58 | 11,493
ovarian cancer 53 | 8,520
medulloblastoma, large-cell 47 | 6,241
osteosarcoma 47 | 7,950
glioblastoma 45 | 5,792
Cancer 42 | 2,499
atypical teratoid / rhabdoid tumor 42 | 5,112
psoriasis 38 | 6,694
ependymoma 34 | 4,679
Breast cancer 32 | 3,578
adult high grade glioma 28 | 3,801
lung cancer 27 | 4,740
Astrocytoma, Pilocytic 26 | 3,081
oligodendroglioma 24 | 2,850
primitive neuroectodermal tumor 24 | 3,035
Kidney cancer 23 | 2,613
group 3 medulloblastoma 22 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
pancreatic cancer 21 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
diabetes mellitus 19 | 1,728
group 4 medulloblastoma 19 | 1,855
malignant mesothelioma 19 | 3,232
Schizophrenia 18 | 1,160
astrocytic glioma 18 | 2,597
subependymal giant cell astrocytoma 18 | 2,287
Pick disease 16 | 1,894
non-small cell lung cancer 16 | 2,890
breast carcinoma 15 | 1,638
invasive ductal carcinoma 15 | 2,951
juvenile dermatomyositis 15 | 1,187
Intellectual disability 13 | 1,016
tuberculosis 13 | 2,010
Alzheimer's disease 12 | 658
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Stomach Neoplasms 12 | 300
Vascular disease 12 | 319
Lung Neoplasms 11 | 232
Waldenstrons macroglobulinemia 11 | 765
astrocytoma 11 | 1,146
ductal carcinoma in situ 11 | 1,745
lung adenocarcinoma 11 | 2,716
pituitary cancer 11 | 1,972
Endometrial cancer 10 | 311
Neoplasm Invasiveness 10 | 161
Parkinson's disease 10 | 392
Rheumatoid arthritis 10 | 1,191
cystic fibrosis 10 | 1,696
Carcinoma, Hepatocellular 9 | 228
Dull intelligence 9 | 645
Liver carcinoma 9 | 240
Liver neoplasms 9 | 130
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Neoplasm Metastasis 9 | 168
Poor school performance 9 | 645
Renal Cell Carcinoma 9 | 214
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Kidney disease 8 | 430
Mental and motor retardation 8 | 608
Multiple myeloma 8 | 1,332
Obesity 8 | 678
Prostatic Neoplasms 8 | 495
acute quadriplegic myopathy 8 | 1,158
colon cancer 8 | 1,478
dermatomyositis 8 | 966
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pediatric high grade glioma 8 | 1,064
spina bifida 8 | 1,074
Arthritis 7 | 290
Colorectal Neoplasms 7 | 243
Hyperalgesia 7 | 83
Hypoplastic mandible condyle 7 | 275
Liver cancer 7 | 604
Mandibular hypoplasia 7 | 275
Melanoma 7 | 711
Micrognathism 7 | 275
Precancerous Conditions 7 | 80
adrenocortical carcinoma 7 | 1,428
lung carcinoma 7 | 2,843
pancreatic carcinoma 7 | 562
progressive supranuclear palsy 7 | 676
Adenoma 6 | 167
Autosomal recessive predisposition 6 | 1,442
Congenital Epicanthus 6 | 177
Depressive disorder 6 | 409
Endometriosis 6 | 540
Heart disease 6 | 306
Short stature 6 | 531
Strabismus 6 | 270
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,312
primary Sjogren syndrome 6 | 735
ulcerative colitis 6 | 1,819

Tissue

Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Endocrine System 70 | 18,159
Female tissues 70 | 17,400
Liver and Pancreas 70 | 16,750
Male tissues 70 | 17,142
Nervous System 70 | 16,725
Skin and soft tissues 70 | 17,230
Urinary Tract 70 | 16,678
Cardiovascular System 69 | 15,192
Respiratory system 69 | 16,393

Target Family

Kinase 29 | 634
Non-IDG 28 | 12,091
Enzyme 9 | 4,145
Transcription Factor 4 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Actin-related protein 2 ACTR2 Tbio Non-IDG -1.88412 78.5 211
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Rho GDP-dissociation inhibitor 1 ARHGDIA Tchem Non-IDG -2.56885 370.1 382
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.80594 64.5 160
Actin-related protein 2/3 complex subunit 2 ARPC2 Tbio Non-IDG -1.31089 16.9 270
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Actin-related protein 2/3 complex subunit 4 ARPC4 Tbio Non-IDG -1.00650 0.00000 120
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998