Development Level

Tbio 34 | 11,445
Tchem 9 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating triglyce... 2 | 79
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal esophagus morphology 1 | 5
abnormal lung morphology 1 | 26
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
shortened RR interval 1 | 17
shortened ST segment 1 | 10
tremors 1 | 39

Disease

Carcinoma 37 | 11,493
lung cancer 33 | 4,740
ovarian cancer 32 | 8,520
Cancer 31 | 2,499
psoriasis 28 | 6,694
medulloblastoma, large-cell 27 | 6,241
glioblastoma 25 | 5,792
osteosarcoma 25 | 7,950
atypical teratoid / rhabdoid tumor 24 | 5,112
Breast cancer 22 | 3,578
ependymoma 22 | 4,679
malignant mesothelioma 20 | 3,232
pancreatic cancer 19 | 2,398
group 3 medulloblastoma 18 | 4,104
non-small cell lung cancer 18 | 2,890
primitive neuroectodermal tumor 18 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Breast Neoplasms 16 | 445
interstitial cystitis 16 | 2,312
oligodendroglioma 16 | 2,850
Mammary Neoplasms 15 | 425
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
Astrocytoma, Pilocytic 13 | 3,081
tuberculosis 13 | 2,010
breast carcinoma 12 | 1,638
cystic fibrosis 12 | 1,696
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
ulcerative colitis 12 | 1,819
Autosomal recessive predisposition 11 | 1,442
Kidney cancer 11 | 2,613
acute quadriplegic myopathy 11 | 1,158
colon cancer 10 | 1,478
diabetes mellitus 10 | 1,728
esophageal adenocarcinoma 10 | 737
invasive ductal carcinoma 10 | 2,951
pituitary cancer 10 | 1,972
nasopharyngeal carcinoma 9 | 1,058
Liver Cirrhosis, Experimental 8 | 769
Melanoma 8 | 711
Prostatic Neoplasms 8 | 495
Skin cancer 8 | 469
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
pediatric high grade glioma 8 | 1,064
spina bifida 8 | 1,074
Bipolar Disorder 7 | 666
Carcinoma, Squamous Cell 7 | 110
Liver cancer 7 | 604
Lung Neoplasms 7 | 232
group 4 medulloblastoma 7 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
subependymal giant cell astrocytoma 7 | 2,287
Cell Transformation, Neoplastic 6 | 97
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
Lymphoma 6 | 81
Neoplastic Cell Transformation 6 | 89
Polycystic ovary syndrome 6 | 360
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Short stature 6 | 531
Squamous cell carcinoma 6 | 129
gastric carcinoma 6 | 807
juvenile dermatomyositis 6 | 1,187
Adenocarcinoma of lung 5 | 142
Adenoid Cystic Carcinoma 5 | 99
Carcinoma, Adenoid Cystic 5 | 99
Carcinoma, Hepatocellular 5 | 228
Carcinoma, Non-Small-Cell Lung 5 | 107
Endometriosis 5 | 540
Esophageal Squamous Cell Carcinoma 5 | 77
Fever 5 | 138
Liver carcinoma 5 | 240
Pancreatic Neoplasm 5 | 85
Pancreatic Neoplasms 5 | 85
Squamous cell carcinoma of esophagus 5 | 77
aldosterone-producing adenoma 5 | 665
inflammatory breast cancer 5 | 286
non-small cell lung carcinoma 5 | 317
primary pancreatic ductal adenocarcinoma 5 | 1,109
Alzheimer's disease 4 | 658
Depressive disorder 4 | 409
Duchenne muscular dystrophy 4 | 601
Hypertension 4 | 396
Kidney disease 4 | 430
Mental Depression 4 | 333
Multiple Sclerosis 4 | 540
Neuroblastoma 4 | 80
Pick disease 4 | 1,894
Vascular disease 4 | 319
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
medulloblastoma 4 | 720
primary Sjogren syndrome 4 | 735

Tissue

Blood and immune system 47 | 16,909
Digestive Tract 47 | 17,369
Endocrine System 47 | 18,159
Skin and soft tissues 47 | 17,230
Female tissues 46 | 17,400
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Urinary Tract 46 | 16,678
Liver and Pancreas 45 | 16,750
Respiratory system 45 | 16,393
Cardiovascular System 42 | 15,192

Target Family

Non-IDG 20 | 12,091
Enzyme 12 | 4,145
Transcription Factor 11 | 1,400
Kinase 3 | 634
GPCR 1 | 408
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 48 | 48
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SEC14-like protein 2 SEC14L2 Tbio Non-IDG -1.94705 87.1 159
Brachyury protein TBXT Tbio Transcription Factor -2.24737 158.4 337
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.88264 723.0 847
Keratin, type I cytoskeletal 14 KRT14 Tbio Non-IDG -2.90790 721.6 780
CCAAT/enhancer-binding protein delta CEBPD Tbio Transcription Factor -2.49029 299.9 179
Glutathione peroxidase 2 GPX2 Tbio Enzyme -2.29928 197.6 144
GTP-binding protein RAD RRAD Tbio Enzyme -2.52208 334.4 122
Keratin, type II cytoskeletal 5 KRT5 Tbio Non-IDG -2.87489 691.1 885
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575