Development Level

Tchem 20 | 1,598
Tbio 17 | 11,445
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97
small testis 1 | 58

Disease

Carcinoma 35 | 11,493
osteosarcoma 35 | 7,950
ovarian cancer 33 | 8,520
Cancer 28 | 2,499
lung cancer 22 | 4,740
glioblastoma 20 | 5,792
medulloblastoma, large-cell 19 | 6,241
psoriasis 19 | 6,694
Breast cancer 17 | 3,578
diabetes mellitus 16 | 1,728
interstitial cystitis 15 | 2,312
invasive ductal carcinoma 15 | 2,951
lung carcinoma 15 | 2,843
Kidney cancer 14 | 2,613
adult high grade glioma 13 | 3,801
atypical teratoid / rhabdoid tumor 13 | 5,112
pancreatic cancer 13 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
subependymal giant cell astrocytoma 12 | 2,287
juvenile dermatomyositis 11 | 1,187
primary Sjogren syndrome 11 | 735
cutaneous lupus erythematosus 10 | 1,057
ulcerative colitis 10 | 1,819
Astrocytoma, Pilocytic 9 | 3,081
Autosomal recessive predisposition 9 | 1,442
Breast Neoplasms 9 | 445
Waldenstrons macroglobulinemia 9 | 765
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
non-small cell lung cancer 9 | 2,890
tuberculosis 9 | 2,010
Blastic phase chronic myeloid leukemia 8 | 58
Chronic Myelocytic Leukemia Accelerated Phase 8 | 59
Failure to gain weight 8 | 365
Mammary Neoplasms 8 | 425
Melanoma 8 | 711
Pediatric failure to thrive 8 | 365
Stomach Neoplasms 8 | 300
astrocytoma 8 | 1,146
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
Byzanthine arch palate 7 | 194
Chronic Lymphocytic Leukemia 7 | 262
Diarrhea 7 | 253
Frontal bossing 7 | 157
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
Orbital separation excessive 7 | 244
Renal Cell Carcinoma 7 | 214
acute myeloid leukemia 7 | 783
ductal carcinoma in situ 7 | 1,745
oligodendroglioma 7 | 2,850
pancreatic carcinoma 7 | 562
Acquired scoliosis 6 | 281
Agammaglobulinemia 6 | 34
Arthritis 6 | 290
Big calvaria 6 | 147
Chronic phase chronic myeloid leukemia 6 | 45
Concave bridge of nose 6 | 195
Curvature of spine 6 | 282
Delayed bone age 6 | 136
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Downward slant of palpebral fissure 6 | 158
Dull intelligence 6 | 645
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Fibrous skin tumor of tuberous sclerosis 6 | 18
Hemangioma 6 | 69
Hemangioma, Cavernous 6 | 20
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Melanocytic nevus 6 | 43
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Noncancerous mole 6 | 28
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 6 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 6 | 47
Poor school performance 6 | 645
Sebaceous adenoma 6 | 26
Seizures 6 | 596
Short stature 6 | 531
Splenomegaly 6 | 190
Transitional cell carcinoma of bladder 6 | 17
Upper respiratory tract disease 6 | 15
Vascular disease 6 | 319
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
dermatomyositis 6 | 966
primitive neuroectodermal tumor 6 | 3,035
Schizophrenia 5 | 1,160
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Respiratory system 46 | 16,393
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678
Nervous System 45 | 16,725

Target Family

Kinase 19 | 634
Enzyme 15 | 4,145
Non-IDG 11 | 12,091
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 ARAP3 Tbio Non-IDG -0.96067 13.8 85
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Cytohesin-3 CYTH3 Tbio Non-IDG -1.83094 69.1 156
Cytohesin-1 CYTH1 Tbio Non-IDG -2.10475 140.2 194