Development Level

Tbio 15 | 11,445
Tchem 15 | 1,598
Tclin 5 | 613

IMPC Phenotype

increased mean corpuscular hem... 3 | 96
preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased total body fat amoun... 2 | 207
increased circulating LDL chol... 2 | 13
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased cardiac stroke volum... 1 | 1
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 26 | 11,493
ovarian cancer 25 | 8,520
Cancer 24 | 2,499
psoriasis 21 | 6,694
osteosarcoma 19 | 7,950
medulloblastoma, large-cell 18 | 6,241
diabetes mellitus 14 | 1,728
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
Breast cancer 12 | 3,578
ependymoma 12 | 4,679
lung cancer 12 | 4,740
Kidney cancer 11 | 2,613
adult high grade glioma 11 | 3,801
Vascular disease 10 | 319
acute quadriplegic myopathy 9 | 1,158
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
oligodendroglioma 9 | 2,850
Bipolar Disorder 8 | 666
Alzheimer's disease 7 | 658
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Multiple myeloma 7 | 1,332
Obesity 7 | 678
Pick disease 7 | 1,894
Prostatic Neoplasms 7 | 495
Schizophrenia 7 | 1,160
astrocytic glioma 7 | 2,597
dermatomyositis 7 | 966
subependymal giant cell astrocytoma 7 | 2,287
Parkinson's disease 6 | 392
Rheumatoid arthritis 6 | 1,191
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Diabetes Mellitus, Experimental 5 | 108
Epilepsy 5 | 792
Hyperglycemia 5 | 137
Lung Neoplasms 5 | 232
Muscular atrophy 5 | 71
Stomach Neoplasms 5 | 300
Toxic encephalopathy 5 | 141
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
spina bifida 5 | 1,074
Adenoma 4 | 167
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Hepatocellular 4 | 228
Cardiomegaly 4 | 116
Depressive disorder 4 | 409
Hyperinsulinism 4 | 133
Liver carcinoma 4 | 240
Orbital separation excessive 4 | 244
Polycystic ovary syndrome 4 | 360
Renal Cell Carcinoma 4 | 214
Seizures 4 | 596
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
pancreatic cancer 4 | 2,398
primary pancreatic ductal adenocarcinoma 4 | 1,109
primitive neuroectodermal tumor 4 | 3,035
Cardiomyopathies 3 | 110
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Diarrhea 3 | 253
Downward slant of palpebral fissure 3 | 158
Endometrial cancer 3 | 311
Global developmental delay 3 | 608
Heart disease 3 | 306
High forehead 3 | 102
Hypertension 3 | 396
Hypertensive disease 3 | 292
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Major Depressive Disorder 3 | 301
Mental and motor retardation 3 | 608
Microstomia 3 | 78
Mood Disorders 3 | 184
Multiple Sclerosis 3 | 540
Neurodegenerative disease 3 | 414
Osteoarthritis 3 | 184
Osteoporosis 3 | 363
Tall forehead 3 | 102
Waldenstrons macroglobulinemia 3 | 765
ductal carcinoma in situ 3 | 1,745
nasopharyngeal carcinoma 3 | 1,058
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972

Tissue

Blood and immune system 35 | 16,909
Cardiovascular System 35 | 15,192
Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678

Target Family

Non-IDG 15 | 12,091
Kinase 13 | 634
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400
Transporter 1 | 473

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
TBC1 domain family member 4 TBC1D4 Tbio Non-IDG -2.06751 113.5 300