Development Level

Tbio 39 | 11,445
Tchem 18 | 1,598
Tclin 8 | 613
Tdark 1 | 6,588

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal femur morphology 2 | 14
abnormal retina morphology 2 | 71
decreased hematocrit 2 | 46
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
abnormal behavioral response t... 1 | 66
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal snout morphology 1 | 23
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 56 | 11,493
ovarian cancer 47 | 8,520
glioblastoma 40 | 5,792
osteosarcoma 40 | 7,950
Cancer 39 | 2,499
Breast cancer 38 | 3,578
Kidney cancer 37 | 2,613
psoriasis 35 | 6,694
atypical teratoid / rhabdoid tumor 32 | 5,112
ependymoma 31 | 4,679
medulloblastoma, large-cell 31 | 6,241
lung cancer 29 | 4,740
Astrocytoma, Pilocytic 27 | 3,081
pancreatic cancer 26 | 2,398
invasive ductal carcinoma 25 | 2,951
lung adenocarcinoma 24 | 2,716
adult high grade glioma 23 | 3,801
malignant mesothelioma 23 | 3,232
breast carcinoma 22 | 1,638
interstitial cystitis 22 | 2,312
diabetes mellitus 20 | 1,728
non-small cell lung cancer 20 | 2,890
ductal carcinoma in situ 19 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
primitive neuroectodermal tumor 19 | 3,035
Autosomal recessive predisposition 18 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
oligodendroglioma 18 | 2,850
Liver Cirrhosis, Experimental 17 | 769
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
juvenile dermatomyositis 17 | 1,187
lung carcinoma 17 | 2,843
Duchenne muscular dystrophy 16 | 601
Kidney disease 16 | 430
gastric carcinoma 16 | 807
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
Melanoma 15 | 711
Pick disease 15 | 1,894
cystic fibrosis 15 | 1,696
limb girdle muscular dystrophy 2A 15 | 213
ulcerative colitis 15 | 1,819
Becker muscular dystrophy 14 | 191
Myopia 14 | 176
Schizophrenia 14 | 1,160
Short stature 14 | 531
adrenocortical carcinoma 14 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 510
group 4 medulloblastoma 14 | 1,855
nasopharyngeal carcinoma 14 | 1,058
Acquired scoliosis 13 | 281
Arthritis 13 | 290
Curvature of spine 13 | 282
Hypoplastic mandible condyle 13 | 275
Mandibular hypoplasia 13 | 275
Micrognathism 13 | 275
Skin cancer 13 | 469
group 3 medulloblastoma 13 | 4,104
pituitary cancer 13 | 1,972
Hypertension 12 | 396
acute quadriplegic myopathy 12 | 1,158
pediatric high grade glioma 12 | 1,064
subependymal giant cell astrocytoma 12 | 2,287
Liver cancer 11 | 604
Neoplasm Metastasis 11 | 168
Osteoporosis 11 | 363
Pectus excavatum 11 | 100
Prostatic Neoplasms 11 | 495
primary pancreatic ductal adenocarcinoma 11 | 1,109
urothelial carcinoma 11 | 318
Atherosclerosis 10 | 291
Degenerative polyarthritis 10 | 115
Heart disease 10 | 306
Hypertensive disease 10 | 292
Joint laxity 10 | 54
Orbital separation excessive 10 | 244
Vascular disease 10 | 319
astrocytic glioma 10 | 2,597
Abortion, Spontaneous 9 | 109
Cataract 9 | 297
Cognitive delay 9 | 608
Depressive disorder 9 | 409
Global developmental delay 9 | 608
Hyperkyphosis 9 | 111
Joint hyperflexibility 9 | 78
Kyphosis deformity of spine 9 | 114
Lung Neoplasms 9 | 232
Mental and motor retardation 9 | 608
Neoplasm Invasiveness 9 | 161
Spontaneous abortion 9 | 113
Squamous cell carcinoma 9 | 129
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
esophageal adenocarcinoma 9 | 737
interstitial lung disease 9 | 298
tuberculosis 9 | 2,010
Alzheimer's disease 8 | 658
dermatomyositis 8 | 966
pterygium 8 | 76

Tissue

Digestive Tract 66 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Skin and soft tissues 65 | 17,230
Blood and immune system 64 | 16,909
Respiratory system 64 | 16,393
Urinary Tract 64 | 16,678
Nervous System 63 | 16,725
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 40 | 12,091
Kinase 18 | 634
Enzyme 6 | 4,145
GPCR 1 | 408
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-2(V) chain COL5A2 Tbio Non-IDG -1.69982 44.6 96
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Adhesion G protein-coupled receptor A2 ADGRA2 Tbio GPCR -1.45203 30.0 211
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Collagen alpha-3(VI) chain COL6A3 Tbio Non-IDG -1.79687 61.3 32
Collagen alpha-1(XI) chain COL11A1 Tbio Non-IDG -2.15516 138.4 96
Collagen alpha-1(VI) chain COL6A1 Tbio Non-IDG -2.03348 104.7 204
Collagen alpha-2(VI) chain COL6A2 Tbio Non-IDG -1.80531 59.2 151