Development Level

Tbio 38 | 11,445
Tchem 20 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal lens morphology 3 | 81
cataract 3 | 92
abnormal embryo size 2 | 220
female infertility 2 | 60
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
microphthalmia 1 | 26
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Cancer 51 | 2,499
Carcinoma 44 | 11,493
ovarian cancer 44 | 8,520
osteosarcoma 42 | 7,950
medulloblastoma, large-cell 35 | 6,241
psoriasis 33 | 6,694
glioblastoma 32 | 5,792
lung cancer 31 | 4,740
group 3 medulloblastoma 30 | 4,104
malignant mesothelioma 28 | 3,232
atypical teratoid / rhabdoid tumor 25 | 5,112
Breast cancer 23 | 3,578
ependymoma 19 | 4,679
primitive neuroectodermal tumor 18 | 3,035
lung adenocarcinoma 17 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
Astrocytoma, Pilocytic 15 | 3,081
Kidney cancer 15 | 2,613
Schizophrenia 15 | 1,160
astrocytoma 15 | 1,146
colon cancer 15 | 1,478
subependymal giant cell astrocytoma 15 | 2,287
adult high grade glioma 14 | 3,801
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
Breast Neoplasms 13 | 445
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Mammary Neoplasms 13 | 425
Rheumatoid arthritis 13 | 1,191
oligodendroglioma 13 | 2,850
Intellectual disability 12 | 1,016
Waldenstrons macroglobulinemia 12 | 765
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
juvenile dermatomyositis 12 | 1,187
Multiple myeloma 11 | 1,332
lung carcinoma 11 | 2,843
pancreatic cancer 11 | 2,398
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
Melanoma 10 | 711
acute quadriplegic myopathy 10 | 1,158
diabetes mellitus 10 | 1,728
ductal carcinoma in situ 10 | 1,745
Acquired scoliosis 9 | 281
Broad flat nasal bridge 9 | 236
Curvature of spine 9 | 282
Lung Neoplasms 9 | 232
Nasal bridge wide 9 | 236
Prostatic Neoplasms 9 | 495
Short stature 9 | 531
Small head 9 | 374
Stomach Neoplasms 9 | 300
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
Asthma 8 | 385
Colonic Neoplasms 8 | 142
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Dull intelligence 8 | 645
Epilepsy 8 | 792
Immune system cancer 8 | 140
Leukemia, Myelocytic, Acute 8 | 120
Leukemia, Myeloid, Acute 8 | 105
Liver neoplasms 8 | 130
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Obesity 8 | 678
Orbital separation excessive 8 | 244
Poor school performance 8 | 645
Seizures 8 | 596
Vascular disease 8 | 319
adrenocortical carcinoma 8 | 1,428
dermatomyositis 8 | 966
medulloblastoma 8 | 720
nasopharyngeal carcinoma 8 | 1,058
pituitary cancer 8 | 1,972
Cognitive delay 7 | 608
Deafness 7 | 198
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Lymphoid leukemia 7 | 160
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Muscle hypotonia 7 | 571
Strabismus 7 | 270
acute myeloid leukemia 7 | 783
cystic fibrosis 7 | 1,696
group 4 medulloblastoma 7 | 1,855
hearing impairment 7 | 199
Atopic dermatitis 6 | 952
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
chronic lymphosyte leukemia 6 | 204
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Blood and immune system 65 | 16,909
Female tissues 65 | 17,400
Urinary Tract 65 | 16,678
Liver and Pancreas 64 | 16,750
Nervous System 64 | 16,725
Respiratory system 62 | 16,393
Cardiovascular System 61 | 15,192

Target Family

Transcription Factor 21 | 1,400
Non-IDG 17 | 12,091
Kinase 11 | 634
Epigenetic 9 | 242
Enzyme 8 | 4,145
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.21333 1562.7 1125
Retinol-binding protein 2 RBP2 Tbio Non-IDG -2.08995 120.9 150
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.48992 0.00000 324
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Pulmonary surfactant-associated protein D SFTPD Tbio Non-IDG -2.81488 698.4 291
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
CCAAT/enhancer-binding protein delta CEBPD Tbio Transcription Factor -2.49029 299.9 179
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518