Development Level

Tbio 17 | 11,445
Tchem 13 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased lactate dehydrogenas... 1 | 16
embryonic lethality prior to o... 1 | 239
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
prenatal lethality 1 | 28

Disease

Carcinoma 22 | 11,493
osteosarcoma 20 | 7,950
ovarian cancer 20 | 8,520
glioblastoma 18 | 5,792
medulloblastoma, large-cell 18 | 6,241
ependymoma 15 | 4,679
Cancer 14 | 2,499
atypical teratoid / rhabdoid tumor 14 | 5,112
lung cancer 13 | 4,740
Kidney cancer 12 | 2,613
psoriasis 12 | 6,694
astrocytic glioma 11 | 2,597
lung adenocarcinoma 11 | 2,716
oligodendroglioma 11 | 2,850
Astrocytoma, Pilocytic 10 | 3,081
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
group 3 medulloblastoma 10 | 4,104
invasive ductal carcinoma 10 | 2,951
primitive neuroectodermal tumor 10 | 3,035
Noonan syndrome 9 | 34
Melanoma 8 | 711
group 4 medulloblastoma 8 | 1,855
Blepharoptosis 7 | 231
Cryptorchidism 7 | 296
Downward slant of palpebral fissure 7 | 158
Muscle hypotonia 7 | 571
Neck webbing 7 | 35
Orbital separation excessive 7 | 244
Pick disease 7 | 1,894
Short stature 7 | 531
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
Abnormal dermatoglyphic pattern 6 | 24
Acquired scoliosis 6 | 281
Bleeding tendency 6 | 37
Byzanthine arch palate 6 | 194
Cardiac Arrhythmia 6 | 103
Cardiac conduction abnormalities 6 | 78
Conduction disorder of the heart 6 | 79
Congenital pectus carinatum 6 | 52
Curvature of spine 6 | 282
Decreased projection of midface 6 | 105
Delayed bone age 6 | 136
EKG abnormalities 6 | 78
Electrocardiogram abnormal 6 | 81
Electrocardiogram change 6 | 78
Excess nuchal skin 6 | 30
Exophthalmos 6 | 112
Full lower lip 6 | 64
Hypoplastic mandible condyle 6 | 275
Hypotrophic midface 6 | 105
Intellectual disability 6 | 1,016
Joint hyperflexibility 6 | 78
Low posterior hairline 6 | 52
Low-set, posteriorly rotated ears 6 | 110
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Midface retrusion 6 | 105
Muscle Weakness 6 | 170
Prominent lower lip 6 | 64
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Small midface 6 | 105
Stomach Neoplasms 6 | 300
Strabismus 6 | 270
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Abnormality of pulmonary valve 5 | 23
Autistic Disorder 5 | 364
Blood Coagulation Disorders 5 | 42
Coagulation abnormalities 5 | 27
Coarse hair 5 | 31
Dull intelligence 5 | 645
Dysarthria 5 | 192
Epilepsy 5 | 792
Feeding difficulties in infancy 5 | 175
Hemorrhagic Disorders 5 | 30
Hepatomegaly 5 | 285
High forehead 5 | 102
Low intelligence 5 | 645
Lymphangioma, Cystic 5 | 21
Mental deficiency 5 | 645
Pectus excavatum 5 | 100
Poor school performance 5 | 645
Prominent eyes 5 | 96
Prominent globes 5 | 96
Protruding eyes 5 | 96
Rough hair texture 5 | 31
Short neck 5 | 140
Tall forehead 5 | 102
Triangular face 5 | 58
astrocytoma 5 | 1,146
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 9 | 4,145
Kinase 5 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 31 | 31
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.47836 299.2 58
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99
Ras-specific guanine nucleotide-releasing factor 2 RASGRF2 Tbio Non-IDG -1.31521 23.7 21
Neurofibromin NF1 Tbio Non-IDG -3.60161 4054.2 355