Development Level

Tbio 9 | 11,445
Tchem 7 | 1,598
Tclin 2 | 613

IMPC Phenotype

decreased body length 2 | 101
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal limb morphology 1 | 13
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
protruding tongue 1 | 3
small superior vagus ganglion 1 | 74

Disease

Carcinoma 16 | 11,493
ovarian cancer 13 | 8,520
Cancer 12 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
glioblastoma 9 | 5,792
medulloblastoma, large-cell 7 | 6,241
Kidney cancer 6 | 2,613
Schizophrenia 6 | 1,160
adult high grade glioma 6 | 3,801
lung cancer 6 | 4,740
Renal Cell Carcinoma 5 | 214
ependymoma 5 | 4,679
malignant mesothelioma 5 | 3,232
medulloblastoma 5 | 720
oligodendroglioma 5 | 2,850
Bipolar Disorder 4 | 666
Breast cancer 4 | 3,578
Familial adenomatous polyposis 4 | 32
Liver cancer 4 | 604
Osteoporosis 4 | 363
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Alzheimer's disease 3 | 658
Carcinoma of colon 3 | 32
Carcinoma, Hepatocellular 3 | 228
Colonic Neoplasms 3 | 142
Colorectal Neoplasms 3 | 243
Endometrial cancer 3 | 311
Hereditary nonpolyposis colorectal carcinoma 3 | 18
Hypoplastic mandible condyle 3 | 275
Increased gastric cancer 3 | 21
Increased hepatocellular carcinoma risk 3 | 27
Increased incidence of hepatocellular carcinoma 3 | 27
Intellectual disability 3 | 1,016
Leiomyosarcoma of uterus 3 | 13
Liver carcinoma 3 | 240
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Micronodular cirrhosis 3 | 12
Osteoarthritis 3 | 184
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Somatic mutation 3 | 61
Stomach Neoplasms 3 | 300
Subacute progressive viral hepatitis 3 | 9
Transitional cell carcinoma of bladder 3 | 17
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Abdominal Pain 2 | 98
Abnormality of retinal pigmentation 2 | 111
Adenocarcinoma 2 | 122
Adenoma 2 | 167
Bipolar disorder in remission 2 | 19
Craniofacial Abnormalities 2 | 151
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Depressive disorder 2 | 409
ENSP00000256078 2 | 30
Fever 2 | 138
Hypodontia 2 | 81
Hypoplasia of the maxilla 2 | 66
Hypotrophic maxilla 2 | 66
Large intestine cancer 2 | 126
Liver neoplasms 2 | 130
Long philtrum 2 | 137
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Lynch syndrome 2 | 35
Major Depressive Disorder 2 | 301
Malabsorption 2 | 82
Maxillary retrognathia 2 | 66
Melanoma 2 | 711
Muscular atrophy 2 | 71
Oligodontia 2 | 24
Retinal pigment epithelial abnormality 2 | 111
Retrusion of upper jaw bones 2 | 66
Skin cancer 2 | 469
Stevens-Johnson syndrome 2 | 92
Thin upper lip vermilion 2 | 67
Tooth agenesis 2 | 44
Vascular disease 2 | 319
esophageal adenocarcinoma 2 | 737
posterior fossa group A ependymoma 2 | 468

Tissue

Digestive Tract 17 | 17,369
Female tissues 17 | 17,400
Male tissues 17 | 17,142
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Endocrine System 16 | 18,159
Liver and Pancreas 16 | 16,750
Nervous System 16 | 16,725
Urinary Tract 16 | 16,678

Target Family

Non-IDG 11 | 12,091
Kinase 5 | 634
Enzyme 1 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

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http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.90646 66.5 508
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Axin-2 AXIN2 Tchem Non-IDG -2.44870 241.5 237
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.78290 63.1 310
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Axin-1 AXIN1 Tbio Non-IDG -2.52218 301.0 370
Segment polarity protein dishevelled homolog DVL-2 DVL2 Tbio Non-IDG -1.87063 68.4 288