Development Level

Tchem 25 | 1,598
Tbio 17 | 11,445
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 3 | 187
increased neutrophil cell numb... 3 | 46
abnormal gait 2 | 69
decreased lymphocyte cell numb... 2 | 83
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
increased circulating glucose ... 2 | 24
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating iron lev... 1 | 32
decreased heart weight 1 | 27
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Cancer 45 | 2,499
Carcinoma 45 | 11,493
osteosarcoma 35 | 7,950
ovarian cancer 35 | 8,520
glioblastoma 32 | 5,792
psoriasis 32 | 6,694
medulloblastoma, large-cell 31 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
lung cancer 26 | 4,740
Breast cancer 20 | 3,578
Rheumatoid arthritis 19 | 1,191
ependymoma 19 | 4,679
invasive ductal carcinoma 18 | 2,951
malignant mesothelioma 17 | 3,232
Multiple myeloma 16 | 1,332
Schizophrenia 16 | 1,160
adult high grade glioma 16 | 3,801
group 3 medulloblastoma 16 | 4,104
Asthma 15 | 385
Astrocytoma, Pilocytic 15 | 3,081
Kidney cancer 15 | 2,613
diabetes mellitus 15 | 1,728
lung adenocarcinoma 15 | 2,716
Lung Neoplasms 14 | 232
Stomach Neoplasms 14 | 300
group 4 medulloblastoma 14 | 1,855
interstitial cystitis 14 | 2,312
lung carcinoma 14 | 2,843
tuberculosis 14 | 2,010
Vascular disease 13 | 319
breast carcinoma 13 | 1,638
non-small cell lung cancer 13 | 2,890
pituitary cancer 13 | 1,972
Arthritis 12 | 290
ductal carcinoma in situ 12 | 1,745
juvenile dermatomyositis 12 | 1,187
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
Melanoma 11 | 711
Multiple Sclerosis 11 | 540
Short stature 11 | 531
pancreatic cancer 11 | 2,398
Alzheimer's disease 10 | 658
Breast Neoplasms 10 | 445
Byzanthine arch palate 10 | 194
Carcinoma, Hepatocellular 10 | 228
Disease Models, Animal 10 | 155
Liver carcinoma 10 | 240
Mammary Neoplasms 10 | 425
Neoplasm Metastasis 10 | 168
Orbital separation excessive 10 | 244
astrocytic glioma 10 | 2,597
astrocytoma 10 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 10 | 1,819
Acquired scoliosis 9 | 281
Carcinoma, Squamous Cell 9 | 110
Cell Transformation, Neoplastic 9 | 97
Chronic Lymphocytic Leukemia 9 | 262
Curvature of spine 9 | 282
Downward slant of palpebral fissure 9 | 158
Heart disease 9 | 306
Hypoplastic mandible condyle 9 | 275
Immune system cancer 9 | 140
Liver Cirrhosis, Experimental 9 | 769
Liver neoplasms 9 | 130
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Muscle hypotonia 9 | 571
Noonan syndrome 9 | 34
Pick disease 9 | 1,894
Squamous cell carcinoma 9 | 129
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Atopic dermatitis 8 | 952
Blepharoptosis 8 | 231
Congenital Epicanthus 8 | 177
Delayed bone age 8 | 136
Diarrhea 8 | 253
Dull intelligence 8 | 645
Frontal bossing 8 | 157
Hepatomegaly 8 | 285
High forehead 8 | 102
Hypertrophic Cardiomyopathy 8 | 117
Intellectual disability 8 | 1,016
Joint hyperflexibility 8 | 78
Kidney disease 8 | 430
Low intelligence 8 | 645
Lung disease 8 | 142
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Neck webbing 8 | 35
Obesity 8 | 678
Pectus excavatum 8 | 100
Poor school performance 8 | 645
Strabismus 8 | 270
Tall forehead 8 | 102
cutaneous lupus erythematosus 8 | 1,057
pancreatic carcinoma 8 | 562
primary Sjogren syndrome 8 | 735

Tissue

Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Skin and soft tissues 54 | 17,230
Cardiovascular System 53 | 15,192
Endocrine System 53 | 18,159
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Urinary Tract 53 | 16,678

Target Family

Kinase 21 | 634
Non-IDG 19 | 12,091
Transcription Factor 8 | 1,400
Enzyme 6 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 54 | 54
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.16502 140.7 702