Development Level

Tbio 16 | 11,445
Tchem 13 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
tremors 2 | 39
abnormal esophagus morphology 1 | 5
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
prenatal lethality 1 | 28

Disease

Carcinoma 28 | 11,493
Cancer 25 | 2,499
osteosarcoma 23 | 7,950
glioblastoma 22 | 5,792
psoriasis 22 | 6,694
medulloblastoma, large-cell 21 | 6,241
ovarian cancer 21 | 8,520
lung cancer 18 | 4,740
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 15 | 4,679
Breast cancer 14 | 3,578
Schizophrenia 14 | 1,160
Kidney cancer 13 | 2,613
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
pituitary cancer 11 | 1,972
adult high grade glioma 10 | 3,801
group 4 medulloblastoma 10 | 1,855
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
group 3 medulloblastoma 9 | 4,104
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
juvenile dermatomyositis 9 | 1,187
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Bipolar Disorder 8 | 666
Breast Neoplasms 8 | 445
astrocytic glioma 8 | 2,597
ductal carcinoma in situ 8 | 1,745
ulcerative colitis 8 | 1,819
Mammary Neoplasms 7 | 425
Pick disease 7 | 1,894
Rheumatoid arthritis 7 | 1,191
Stomach Neoplasms 7 | 300
diabetes mellitus 7 | 1,728
lung carcinoma 7 | 2,843
tuberculosis 7 | 2,010
Alzheimer's disease 6 | 658
Depressive disorder 6 | 409
Endometriosis 6 | 540
Intellectual disability 6 | 1,016
Lung Neoplasms 6 | 232
Ovarian Neoplasms 6 | 102
breast carcinoma 6 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
non-small cell lung cancer 6 | 2,890
Amyotrophic lateral sclerosis 5 | 451
Animal Mammary Neoplasms 5 | 136
Arthritis 5 | 290
Autosomal recessive predisposition 5 | 1,442
Dull intelligence 5 | 645
Heart disease 5 | 306
Liver Cirrhosis, Experimental 5 | 769
Low intelligence 5 | 645
Mammary Neoplasms, Animal 5 | 136
Mammary Neoplasms, Experimental 5 | 154
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neoplasm Metastasis 5 | 168
Polycystic ovary syndrome 5 | 360
Poor school performance 5 | 645
Prostatic Neoplasms 5 | 495
cystic fibrosis 5 | 1,696
fibroadenoma 5 | 559
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
ovarian neoplasm 5 | 99
pancreatic carcinoma 5 | 562
Adenocarcinoma 4 | 122
Adenoma 4 | 167
Anemia 4 | 365
Arthritis, Juvenile 4 | 126
Autistic Disorder 4 | 364
Brain Ischemia 4 | 110
Carcinoma, Squamous Cell 4 | 110
Cognitive delay 4 | 608
Disease Models, Animal 4 | 155
Epilepsy 4 | 792
Fatigue 4 | 182
Global developmental delay 4 | 608
Juvenile arthritis 4 | 126
Melanoma 4 | 711
Mental Depression 4 | 333
Mental and motor retardation 4 | 608
Obesity 4 | 678
Squamous cell carcinoma 4 | 129
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Myocardial Ischemia 3 | 169
Vascular disease 3 | 319
esophageal adenocarcinoma 3 | 737
mucosa-associated lymphoid tissue lymphoma 3 | 484

Tissue

Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Liver and Pancreas 35 | 16,750
Skin and soft tissues 35 | 17,230
Blood and immune system 34 | 16,909
Female tissues 34 | 17,400
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Urinary Tract 34 | 16,678
Respiratory system 33 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 15 | 12,091
Kinase 9 | 634
Enzyme 7 | 4,145
Transcription Factor 3 | 1,400
Ion Channel 1 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Protein CBFA2T3 CBFA2T3 Tbio Non-IDG -1.80148 64.9 82
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
Pro-neuregulin-3, membrane-bound isoform NRG3 Tbio Non-IDG -1.56404 39.4 165
WW domain-containing oxidoreductase WWOX Tbio Enzyme -3.61683 3311.4 251
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Prolactin receptor PRLR Tbio Non-IDG -2.77379 616.6 494
Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 Tchem Enzyme -3.55216 3569.0 718