Development Level

Tbio 33 | 11,445
Tchem 26 | 1,598
Tclin 6 | 613

IMPC Phenotype

abnormal behavior 5 | 298
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased circulating amylase ... 2 | 28
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
short tibia 2 | 97
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased urine magnesium leve... 1 | 3
decreased vertical activity 1 | 208
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
polycystic kidney 1 | 15
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 53 | 11,493
ovarian cancer 41 | 8,520
osteosarcoma 39 | 7,950
Cancer 37 | 2,499
glioblastoma 36 | 5,792
medulloblastoma, large-cell 33 | 6,241
atypical teratoid / rhabdoid tumor 30 | 5,112
psoriasis 30 | 6,694
ependymoma 28 | 4,679
lung cancer 26 | 4,740
lung carcinoma 22 | 2,843
Breast cancer 21 | 3,578
adult high grade glioma 21 | 3,801
Kidney cancer 20 | 2,613
oligodendroglioma 20 | 2,850
Astrocytoma, Pilocytic 19 | 3,081
group 3 medulloblastoma 19 | 4,104
primitive neuroectodermal tumor 19 | 3,035
non-small cell lung cancer 18 | 2,890
subependymal giant cell astrocytoma 18 | 2,287
colon cancer 17 | 1,478
diabetes mellitus 17 | 1,728
pancreatic cancer 17 | 2,398
astrocytoma 15 | 1,146
group 4 medulloblastoma 15 | 1,855
ulcerative colitis 15 | 1,819
astrocytic glioma 14 | 2,597
breast carcinoma 14 | 1,638
interstitial cystitis 14 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
lung adenocarcinoma 14 | 2,716
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
pituitary cancer 13 | 1,972
Hypertension 12 | 396
Pick disease 12 | 1,894
Depressive disorder 11 | 409
cystic fibrosis 11 | 1,696
invasive ductal carcinoma 11 | 2,951
tuberculosis 11 | 2,010
Arthritis 10 | 290
Asthma 10 | 385
Carcinoma, Hepatocellular 10 | 228
Cell Transformation, Neoplastic 10 | 97
Heart disease 10 | 306
Hypertensive disease 10 | 292
Kidney disease 10 | 430
Liver carcinoma 10 | 240
Alcoholic Intoxication, Chronic 9 | 289
Alzheimer's disease 9 | 658
Bipolar Disorder 9 | 666
Liver Cirrhosis, Experimental 9 | 769
Mental Depression 9 | 333
Neoplasm Invasiveness 9 | 161
Lung disease 8 | 142
Melanoma 8 | 711
Neoplastic Cell Transformation 8 | 89
Parkinson's disease 8 | 392
Skin cancer 8 | 469
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
pediatric high grade glioma 8 | 1,064
Atherosclerosis 7 | 291
Autosomal recessive predisposition 7 | 1,442
Carcinoma, Squamous Cell 7 | 110
Colorectal Neoplasms 7 | 243
Endometriosis 7 | 540
Epilepsy 7 | 792
Inflammatory bowel disease 7 | 151
Mammary Neoplasms, Experimental 7 | 154
Mood Disorders 7 | 184
Multiple myeloma 7 | 1,332
Obesity 7 | 678
Osteoporosis 7 | 363
Reperfusion Injury 7 | 86
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 783
acute quadriplegic myopathy 7 | 1,158
ductal carcinoma in situ 7 | 1,745
juvenile dermatomyositis 7 | 1,187
primary Sjogren syndrome 7 | 735
Brain Ischemia 6 | 110
Cerebrovascular disease 6 | 238
Colonic Neoplasms 6 | 142
Disease Models, Animal 6 | 155
Eye disease 6 | 62
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
Toxic encephalopathy 6 | 141
adrenocortical carcinoma 6 | 1,428
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
spina bifida 6 | 1,074

Tissue

Blood and immune system 65 | 16,909
Cardiovascular System 65 | 15,192
Digestive Tract 65 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678

Target Family

Non-IDG 25 | 12,091
Enzyme 18 | 4,145
Kinase 12 | 634
GPCR 5 | 408
Transcription Factor 4 | 1,400
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Interleukin-8 CXCL8 Tchem Non-IDG -4.00745 9942.8 1115
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455