Development Level

Tclin 15 | 613
Tchem 7 | 1,598
Tbio 4 | 11,445

IMPC Phenotype

abnormal behavior 2 | 298
abnormal embryo size 2 | 220
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased startle reflex 2 | 112
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased body weight 1 | 25
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glycerol... 1 | 9
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
pale yolk sac 1 | 25
pallor 1 | 34
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 22 | 11,493
osteosarcoma 19 | 7,950
Cancer 18 | 2,499
psoriasis 18 | 6,694
ovarian cancer 15 | 8,520
malignant mesothelioma 12 | 3,232
diabetes mellitus 11 | 1,728
medulloblastoma, large-cell 11 | 6,241
Obesity 10 | 678
glioblastoma 10 | 5,792
Schizophrenia 9 | 1,160
Bipolar Disorder 8 | 666
Carcinoma, Hepatocellular 8 | 228
Liver carcinoma 8 | 240
atypical teratoid / rhabdoid tumor 8 | 5,112
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
Atherosclerosis 7 | 291
Breast Neoplasms 7 | 445
Hypertension 7 | 396
Hypertensive disease 7 | 292
Kaposi's Sarcoma Skin Lesions 7 | 8
Mammary Neoplasms 7 | 425
ductal carcinoma in situ 7 | 1,745
lung cancer 7 | 4,740
pituitary cancer 7 | 1,972
tuberculosis 7 | 2,010
Breast cancer 6 | 3,578
Diabetes Mellitus, Experimental 6 | 108
Endometriosis 6 | 540
Lipid metabolism disorder 6 | 114
Liver disease 6 | 237
Prostatic Neoplasms 6 | 495
adult high grade glioma 6 | 3,801
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
group 4 medulloblastoma 6 | 1,855
Adenocarcinoma 5 | 122
Chemical and Drug Induced Liver Injury 5 | 195
Cholestasis 5 | 155
Colorectal Neoplasms 5 | 243
Coronary artery disease 5 | 268
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Fatty Liver 5 | 70
Fatty liver disease 5 | 103
Hyperglycemia 5 | 137
Insulin Resistance 5 | 72
Kidney Failure, Chronic 5 | 46
Kidney cancer 5 | 2,613
adrenocortical carcinoma 5 | 1,428
interstitial cystitis 5 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Acne vulgaris 4 | 14
Acute promyelocytic leukemia, FAB M3 4 | 11
Alzheimer's disease 4 | 658
Asthma 4 | 385
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Crohn Disease 4 | 45
Diaphragmatic Hernia 4 | 40
Facial Fine Wrinkling 4 | 5
Fine Wrinkling 4 | 5
Heart disease 4 | 306
Hepatomegaly 4 | 285
Hernia, Diaphragmatic 4 | 40
Hyperinsulinism 4 | 133
Hyperkeratosis 4 | 50
Hyperlipidemia 4 | 43
Inflammation 4 | 120
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Liver neoplasms 4 | 130
Mood Disorders 4 | 184
Multiple Sclerosis 4 | 540
Myocardial Infarction 4 | 151
Non-alcoholic Fatty Liver Disease 4 | 42
Osteoporosis 4 | 363
Pancreatic Neoplasms 4 | 85
Pick disease 4 | 1,894
Primary cutaneous T-cell lymphoma 4 | 29
Reperfusion Injury 4 | 86
Severe Recalcitrant Nodular Acne 4 | 5
Solar Lentigines 4 | 6
Stomach Neoplasms 4 | 300
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
sarcoidosis 4 | 370
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Nervous System 25 | 16,725
Cardiovascular System 24 | 15,192

Target Family

Nuclear Receptor 16 | 48
Non-IDG 4 | 12,091
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634
Transporter 1 | 473

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.20455 130.6 2273
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773
Retinoic acid receptor RXR-alpha RXRA Tclin Nuclear Receptor -2.48285 237.9 299
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Nuclear receptor corepressor 2 NCOR2 Tchem Transcription Factor -2.83392 645.1 189
Retinoic acid receptor alpha RARA Tclin Nuclear Receptor -2.97339 919.3 562
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.36613 239.2 307
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
Sterol regulatory element-binding protein 1 SREBF1 Tbio Transcription Factor -3.12075 1267.4 429