Development Level

Tbio 13 | 11,445
Tchem 12 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal seminal vesicle morph... 2 | 114
decreased vertical activity 2 | 208
abnormal brain morphology 1 | 13
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
cataract 1 | 92
decreased circulating alanine ... 1 | 47
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
edema 1 | 59
enlarged adrenal glands 1 | 3
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged uterus 1 | 11
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
irregularly shaped pupil 1 | 7
male infertility 1 | 123
polycystic kidney 1 | 15
preweaning lethality, complete... 1 | 979
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 24 | 11,493
Cancer 23 | 2,499
osteosarcoma 22 | 7,950
ovarian cancer 17 | 8,520
Blastic phase chronic myeloid leukemia 14 | 58
Chronic Myelocytic Leukemia Accelerated Phase 14 | 59
medulloblastoma, large-cell 14 | 6,241
Breast cancer 13 | 3,578
lung cancer 13 | 4,740
Chronic phase chronic myeloid leukemia 12 | 45
Kidney cancer 12 | 2,613
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 12 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 12 | 47
glioblastoma 12 | 5,792
lung carcinoma 12 | 2,843
Astrocytoma, Pilocytic 11 | 3,081
interstitial cystitis 11 | 2,312
psoriasis 11 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
oligodendroglioma 10 | 2,850
pancreatic cancer 10 | 2,398
astrocytic glioma 9 | 2,597
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
ulcerative colitis 9 | 1,819
adult high grade glioma 8 | 3,801
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
non-small cell lung cancer 6 | 2,890
Hypertension 5 | 396
Liver cancer 5 | 604
Waldenstrons macroglobulinemia 5 | 765
diabetes mellitus 5 | 1,728
primary Sjogren syndrome 5 | 735
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Chronic Lymphocytic Leukemia 4 | 262
Kidney disease 4 | 430
Pick disease 4 | 1,894
group 3 medulloblastoma 4 | 4,104
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Acquired immunodeficiency syndrome 3 | 197
Bipolar Disorder 3 | 666
Cognitive delay 3 | 608
Down syndrome 3 | 499
Global developmental delay 3 | 608
Heart disease 3 | 306
Hereditary spherocytosis type 1 3 | 23
Liver Cirrhosis, Experimental 3 | 769
Mental and motor retardation 3 | 608
Rheumatoid arthritis 3 | 1,191
Stomach Neoplasms 3 | 300
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
mucosa-associated lymphoid tissue lymphoma 3 | 484
primary pancreatic ductal adenocarcinoma 3 | 1,109
Alcoholic Intoxication, Chronic 2 | 289
Amyotrophic lateral sclerosis 2 | 451
Atopic dermatitis 2 | 952
Bladder Neoplasm 2 | 112
Cerebrovascular disease 2 | 238
Colorectal Neoplasms 2 | 243
Lissencephaly 2 | 69
Lung disease 2 | 142
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Neoplasm Invasiveness 2 | 161
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Peripheral T-cell lymphoma 2 | 25
Proteinuria 2 | 144
Schizophrenia 2 | 1,160
Urinary Bladder Neoplasms 2 | 114
Vascular disease 2 | 319
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
periodontitis 2 | 293
spina bifida 2 | 1,074

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Blood and immune system 31 | 16,909
Male tissues 31 | 17,142
Cardiovascular System 30 | 15,192
Respiratory system 30 | 16,393
Urinary Tract 30 | 16,678

Target Family

Kinase 20 | 634
Non-IDG 9 | 12,091
Enzyme 4 | 4,145

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ephrin type-A receptor 5 EPHA5 Tchem Kinase -2.28294 191.7 407
Ephrin-A2 EFNA2 Tbio Non-IDG -1.78296 60.7 253
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Ephrin-A3 EFNA3 Tbio Non-IDG -1.53049 26.8 219
Rho guanine nucleotide exchange factor 15 ARHGEF15 Tbio Non-IDG -0.90240 8.54 26
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Tyrosine-protein kinase Fgr FGR Tchem Kinase -2.37977 226.9 400
Phosphoinositide 3-kinase regulatory subunit 6 PIK3R6 Tbio Enzyme 0.00000 69
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227