Development Level

Tbio 26 | 11,445
Tchem 24 | 1,598
Tclin 8 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
decreased circulating alanine ... 2 | 47
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
impaired righting response 1 | 26
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499

Disease

Cancer 44 | 2,499
Carcinoma 37 | 11,493
glioblastoma 36 | 5,792
lung cancer 36 | 4,740
ovarian cancer 36 | 8,520
psoriasis 36 | 6,694
osteosarcoma 32 | 7,950
medulloblastoma, large-cell 30 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
malignant mesothelioma 27 | 3,232
Breast cancer 23 | 3,578
ependymoma 22 | 4,679
Schizophrenia 20 | 1,160
lung adenocarcinoma 20 | 2,716
pituitary cancer 20 | 1,972
Astrocytoma, Pilocytic 19 | 3,081
group 3 medulloblastoma 19 | 4,104
tuberculosis 19 | 2,010
diabetes mellitus 18 | 1,728
non-small cell lung cancer 18 | 2,890
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Obesity 16 | 678
Vascular disease 16 | 319
adult high grade glioma 16 | 3,801
group 4 medulloblastoma 16 | 1,855
primitive neuroectodermal tumor 16 | 3,035
Alzheimer's disease 15 | 658
Arthritis 15 | 290
Lung Neoplasms 15 | 232
colon cancer 15 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Depressive disorder 14 | 409
adrenocortical carcinoma 14 | 1,428
lung carcinoma 14 | 2,843
ulcerative colitis 14 | 1,819
Asthma 13 | 385
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Mental Depression 13 | 333
Prostatic Neoplasms 13 | 495
Stomach Neoplasms 13 | 300
interstitial cystitis 13 | 2,312
invasive ductal carcinoma 13 | 2,951
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
Bipolar Disorder 12 | 666
Hypertension 12 | 396
Rheumatoid arthritis 12 | 1,191
acute myeloid leukemia 12 | 783
cystic fibrosis 12 | 1,696
ductal carcinoma in situ 12 | 1,745
Heart disease 11 | 306
Hypertensive disease 11 | 292
Kidney disease 11 | 430
Liver Cirrhosis, Experimental 11 | 769
Multiple Sclerosis 11 | 540
astrocytoma 11 | 1,146
Atherosclerosis 10 | 291
Cell Transformation, Neoplastic 10 | 97
Lung disease 10 | 142
Multiple myeloma 10 | 1,332
Myocardial Infarction 10 | 151
Parkinson's disease 10 | 392
Reperfusion Injury 10 | 86
Toxic encephalopathy 10 | 141
astrocytic glioma 10 | 2,597
breast carcinoma 10 | 1,638
Diabetes Mellitus, Experimental 9 | 108
Endometriosis 9 | 540
Kidney cancer 9 | 2,613
Neoplasm Metastasis 9 | 168
Neoplastic Cell Transformation 9 | 89
acute quadriplegic myopathy 9 | 1,158
spina bifida 9 | 1,074
subependymal giant cell astrocytoma 9 | 2,287
Atopic dermatitis 8 | 952
Brain Ischemia 8 | 110
Brain disease 8 | 96
Cholestasis, Extrahepatic 8 | 25
Disease Models, Animal 8 | 155
Hyperalgesia 8 | 83
Hyperglycemia 8 | 137
Inflammatory bowel disease 8 | 151
Intellectual disability 8 | 1,016
Liver disease 8 | 237
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 665
gastric cancer 8 | 459
hepatocellular carcinoma 8 | 547
nasopharyngeal carcinoma 8 | 1,058
non primary Sjogren syndrome sicca 8 | 891
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Myocardial Ischemia 7 | 169
mucosa-associated lymphoid tissue lymphoma 7 | 484
periodontitis 7 | 293
urothelial carcinoma 7 | 318

Tissue

Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Endocrine System 59 | 18,159
Female tissues 59 | 17,400
Nervous System 59 | 16,725
Skin and soft tissues 59 | 17,230
Liver and Pancreas 58 | 16,750
Respiratory system 58 | 16,393
Urinary Tract 58 | 16,678
Cardiovascular System 57 | 15,192
Male tissues 56 | 17,142

Target Family

Non-IDG 25 | 12,091
Transcription Factor 12 | 1,400
Enzyme 10 | 4,145
Kinase 9 | 634
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Jun dimerization protein 2 JDP2 Tbio Transcription Factor -1.64730 49.6 72
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.94434 736.0 704
Neurofibromin NF1 Tbio Non-IDG -3.60161 4054.2 355
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Activator of apoptosis harakiri HRK Tbio Non-IDG -2.28324 189.8 167
Transforming growth factor beta-2 TGFB2 Tbio Non-IDG -3.14427 1378.3 384
Acetylcholinesterase ACHE Tclin Enzyme -3.49768 2470.5 505
Core histone macro-H2A.1 H2AFY Tbio Non-IDG -1.78572 69.6 95