Development Level

Tchem 12 | 1,598
Tbio 10 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
hypoactivity 2 | 132
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased basophil cell number 1 | 7
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 20 | 11,493
Cancer 16 | 2,499
ovarian cancer 16 | 8,520
glioblastoma 12 | 5,792
lung cancer 10 | 4,740
psoriasis 10 | 6,694
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
osteosarcoma 9 | 7,950
oligodendroglioma 8 | 2,850
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
tuberculosis 7 | 2,010
Crohn's disease 6 | 321
Kidney cancer 6 | 2,613
Multiple myeloma 6 | 1,332
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
acute quadriplegic myopathy 6 | 1,158
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,728
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Arthritis 5 | 290
Autosomal recessive predisposition 5 | 1,442
Brain Ischemia 5 | 110
Breast Neoplasms 5 | 445
Fever 5 | 138
Immunologic Deficiency Syndromes 5 | 113
Inflammatory bowel disease 5 | 151
Mammary Neoplasms 5 | 425
Multiple Sclerosis 5 | 540
Pick disease 5 | 1,894
acute myeloid leukemia 5 | 783
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
Astrocytoma, Pilocytic 4 | 3,081
Carcinoma, Hepatocellular 4 | 228
Colitis, Ulcerative 4 | 59
Diabetes Mellitus, Experimental 4 | 108
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Leprosy 4 | 73
Liver carcinoma 4 | 240
group 3 medulloblastoma 4 | 4,104
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
mucosa-associated lymphoid tissue lymphoma 4 | 484
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Anemia 3 | 365
Anorexia 3 | 43
Arthritis, Rheumatoid 3 | 174
B-Cell Lymphomas 3 | 12
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Colonic Neoplasms 3 | 142
Constipation 3 | 181
Decreased antibody level in blood 3 | 35
Dyschezia 3 | 135
Epilepsy 3 | 792
Fatigue 3 | 182
Hyperhidrosis disorder 3 | 81
Hypertension 3 | 396
Hypogammaglobulinemia 3 | 35
Hypohidrotic ectodermal dysplasia 3 | 15
Immune system cancer 3 | 140
Increased sweating 3 | 81
Infantile onset 3 | 238
Liver Cirrhosis, Experimental 3 | 769
Lung disease 3 | 142
Lymphadenopathy 3 | 62
Lymphoid leukemia 3 | 160
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Pneumonia 3 | 174
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Sweating 3 | 81
Telangiectasia of the skin 3 | 39
Uveitis 3 | 103
Waldenstrons macroglobulinemia 3 | 765
Weight decreased 3 | 103
adrenocortical carcinoma 3 | 1,428
esophageal adenocarcinoma 3 | 737
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Blood and immune system 24 | 16,909
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 13 | 12,091
Kinase 7 | 634
Enzyme 2 | 4,145
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
ELKS/Rab6-interacting/CAST family member 1 ERC1 Tbio Non-IDG -1.92560 79.7 119
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.73612 54.7 183
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Ubiquitin-conjugating enzyme E2 D3 UBE2D3 Tbio Non-IDG -1.33082 20.0 161
Receptor-interacting serine/threonine-protein kinase 2 RIPK2 Tchem Kinase -2.03990 107.3 474
GTP-binding nuclear protein Ran RAN Tbio Enzyme -2.54769 316.0 452