Development Level

Tchem 18 | 1,598
Tbio 12 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
short tibia 3 | 97
abnormal retina morphology 2 | 71
decreased prepulse inhibition 2 | 82
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
absent seminal vesicle 1 | 4
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
small uterus 1 | 3
thrombocytopenia 1 | 56

Disease

Carcinoma 27 | 11,493
Cancer 26 | 2,499
osteosarcoma 24 | 7,950
ovarian cancer 24 | 8,520
atypical teratoid / rhabdoid tumor 22 | 5,112
medulloblastoma, large-cell 21 | 6,241
glioblastoma 20 | 5,792
lung cancer 18 | 4,740
psoriasis 18 | 6,694
ependymoma 17 | 4,679
adult high grade glioma 14 | 3,801
oligodendroglioma 14 | 2,850
Breast cancer 13 | 3,578
Kidney cancer 12 | 2,613
Schizophrenia 12 | 1,160
Bipolar Disorder 11 | 666
astrocytic glioma 11 | 2,597
group 3 medulloblastoma 11 | 4,104
group 4 medulloblastoma 11 | 1,855
Astrocytoma, Pilocytic 10 | 3,081
diabetes mellitus 10 | 1,728
primitive neuroectodermal tumor 10 | 3,035
juvenile dermatomyositis 9 | 1,187
lung adenocarcinoma 9 | 2,716
Breast Neoplasms 8 | 445
Intellectual disability 8 | 1,016
Mammary Neoplasms 8 | 425
Parkinson's disease 8 | 392
Seizures 8 | 596
Vascular disease 8 | 319
pancreatic cancer 8 | 2,398
Depressive disorder 7 | 409
Downward slant of palpebral fissure 7 | 158
Epilepsy 7 | 792
Hypoplastic mandible condyle 7 | 275
Lung Neoplasms 7 | 232
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Orbital separation excessive 7 | 244
Pick disease 7 | 1,894
Stomach Neoplasms 7 | 300
breast carcinoma 7 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
primary pancreatic ductal adenocarcinoma 7 | 1,109
subependymal giant cell astrocytoma 7 | 2,287
Adenocarcinoma of lung 6 | 142
Adenocarcinoma of lung (disorder) 6 | 60
Alzheimer's disease 6 | 658
Autosomal recessive predisposition 6 | 1,442
Byzanthine arch palate 6 | 194
Carcinoma, Squamous Cell 6 | 110
Cognitive delay 6 | 608
Colorectal Neoplasms 6 | 243
Dull intelligence 6 | 645
Endometrial cancer 6 | 311
Frontal bossing 6 | 157
Global developmental delay 6 | 608
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Multiple myeloma 6 | 1,332
Muscle hypotonia 6 | 571
Noonan syndrome 6 | 34
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Splenomegaly 6 | 190
Squamous cell carcinoma 6 | 129
astrocytoma 6 | 1,146
dermatomyositis 6 | 966
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,312
malignant mesothelioma 6 | 3,232
Acquired scoliosis 5 | 281
Adenoma 5 | 167
Blepharoptosis 5 | 231
Carcinoma, Hepatocellular 5 | 228
Cocaine-Related Disorders 5 | 92
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Curvature of spine 5 | 282
Delayed bone age 5 | 136
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Hepatomegaly 5 | 285
High forehead 5 | 102
Infantile onset 5 | 238
Isolated cases 5 | 72
Joint hyperflexibility 5 | 78
Liver carcinoma 5 | 240
Mental Depression 5 | 333
Pectus excavatum 5 | 100
Tall forehead 5 | 102
Toxic encephalopathy 5 | 141
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 15 | 12,091
Kinase 10 | 634
Enzyme 5 | 4,145
Transcription Factor 4 | 1,400
Ion Channel 2 | 344

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387