Development Level

Tbio 31 | 11,445
Tchem 24 | 1,598
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 4 | 298
decreased total body fat amoun... 3 | 207
abnormal femur morphology 2 | 14
decreased body weight 2 | 161
decreased vertical activity 2 | 208
hyperactivity 2 | 148
increased heart weight 2 | 62
increased startle reflex 2 | 112
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 57 | 11,493
ovarian cancer 41 | 8,520
medulloblastoma, large-cell 37 | 6,241
osteosarcoma 35 | 7,950
glioblastoma 32 | 5,792
atypical teratoid / rhabdoid tumor 31 | 5,112
Cancer 30 | 2,499
lung cancer 30 | 4,740
ependymoma 29 | 4,679
psoriasis 29 | 6,694
group 3 medulloblastoma 27 | 4,104
adult high grade glioma 24 | 3,801
Breast cancer 23 | 3,578
Kidney cancer 22 | 2,613
lung carcinoma 22 | 2,843
Astrocytoma, Pilocytic 21 | 3,081
oligodendroglioma 21 | 2,850
primitive neuroectodermal tumor 21 | 3,035
Schizophrenia 18 | 1,160
colon cancer 18 | 1,478
lung adenocarcinoma 18 | 2,716
non-small cell lung cancer 18 | 2,890
ulcerative colitis 18 | 1,819
astrocytic glioma 17 | 2,597
Hypertension 16 | 396
subependymal giant cell astrocytoma 15 | 2,287
Heart disease 14 | 306
Pick disease 14 | 1,894
breast carcinoma 14 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
invasive ductal carcinoma 14 | 2,951
tuberculosis 14 | 2,010
Kidney disease 13 | 430
diabetes mellitus 13 | 1,728
malignant mesothelioma 13 | 3,232
pancreatic cancer 13 | 2,398
astrocytoma 12 | 1,146
interstitial cystitis 12 | 2,312
Depressive disorder 11 | 409
Intellectual disability 11 | 1,016
Liver Cirrhosis, Experimental 11 | 769
Melanoma 11 | 711
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Arthritis 10 | 290
Asthma 10 | 385
Breast Neoplasms 10 | 445
Epilepsy 10 | 792
Hypertensive disease 10 | 292
Mammary Neoplasms 10 | 425
Obesity 10 | 678
Skin cancer 10 | 469
group 4 medulloblastoma 10 | 1,855
Autosomal recessive predisposition 9 | 1,442
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Lung Neoplasms 9 | 232
Mental Depression 9 | 333
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Osteoporosis 9 | 363
Poor school performance 9 | 645
Rheumatoid arthritis 9 | 1,191
Stomach Neoplasms 9 | 300
Vascular disease 9 | 319
cystic fibrosis 9 | 1,696
pituitary cancer 9 | 1,972
Alzheimer's disease 8 | 658
Bipolar Disorder 8 | 666
Cardiomyopathies 8 | 110
Hyperalgesia 8 | 83
Hypoplastic mandible condyle 8 | 275
Lung disease 8 | 142
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Multiple myeloma 8 | 1,332
Neoplasm Invasiveness 8 | 161
Short stature 8 | 531
Substance Withdrawal Syndrome 8 | 55
ductal carcinoma in situ 8 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
urothelial carcinoma 8 | 318
Crohn's disease 7 | 321
Disease Models, Animal 7 | 155
Hyperglycemia 7 | 137
Major Depressive Disorder 7 | 301
Muscle hypotonia 7 | 571
Premature Birth 7 | 77
Seizures 7 | 596
Unipolar Depression 7 | 250
Waldenstrons macroglobulinemia 7 | 765
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
juvenile dermatomyositis 7 | 1,187
acute myeloid leukemia 6 | 783
cutaneous lupus erythematosus 6 | 1,057
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 807
nephrosclerosis 6 | 333

Tissue

Blood and immune system 64 | 16,909
Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Liver and Pancreas 64 | 16,750
Male tissues 64 | 17,142
Skin and soft tissues 64 | 17,230
Nervous System 63 | 16,725
Respiratory system 63 | 16,393
Urinary Tract 63 | 16,678
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 18 | 4,145
Kinase 18 | 634
GPCR 4 | 408
Transcription Factor 2 | 1,400
Transporter 2 | 473
Ion Channel 1 | 344

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.05332 113.7 111
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.61657 45.3 134