Development Level

Tchem 17 | 1,598
Tbio 14 | 11,445
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
increased leukocyte cell numbe... 2 | 47
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal skin condition 1 | 6
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased basophil cell number 1 | 7
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased thermal nociceptive ... 1 | 9
small superior vagus ganglion 1 | 74

Disease

Cancer 29 | 2,499
Carcinoma 19 | 11,493
glioblastoma 19 | 5,792
ovarian cancer 19 | 8,520
psoriasis 18 | 6,694
lung cancer 17 | 4,740
osteosarcoma 13 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
atypical teratoid / rhabdoid tumor 11 | 5,112
tuberculosis 11 | 2,010
Schizophrenia 10 | 1,160
ependymoma 10 | 4,679
malignant mesothelioma 10 | 3,232
adult high grade glioma 9 | 3,801
lung carcinoma 9 | 2,843
Alzheimer's disease 8 | 658
Astrocytoma, Pilocytic 8 | 3,081
Brain Ischemia 8 | 110
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Diabetes Mellitus, Type 2 8 | 142
Hypersensitivity reaction type II disease 8 | 253
Rheumatoid arthritis 8 | 1,191
Vascular disease 8 | 319
medulloblastoma, large-cell 8 | 6,241
Breast Neoplasms 7 | 445
Diabetes Mellitus, Experimental 7 | 108
Inflammatory bowel disease 7 | 151
Mammary Neoplasms 7 | 425
Toxic encephalopathy 7 | 141
adrenocortical carcinoma 7 | 1,428
colon cancer 7 | 1,478
diabetes mellitus 7 | 1,728
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
pancreatic cancer 7 | 2,398
ulcerative colitis 7 | 1,819
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Breast cancer 6 | 3,578
Kidney cancer 6 | 2,613
Liver Cirrhosis, Experimental 6 | 769
Lung disease 6 | 142
Reperfusion Injury 6 | 86
Splenomegaly 6 | 190
hepatocellular carcinoma 6 | 547
interstitial cystitis 6 | 2,312
subependymal giant cell astrocytoma 6 | 2,287
Asthma 5 | 385
Autosomal recessive predisposition 5 | 1,442
Edema 5 | 81
Fever 5 | 138
Kidney disease 5 | 430
Liver disease 5 | 237
Lung Neoplasms 5 | 232
Parkinson's disease 5 | 392
cutaneous lupus erythematosus 5 | 1,057
group 4 medulloblastoma 5 | 1,855
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
primary pancreatic ductal adenocarcinoma 5 | 1,109
Adenocarcinoma 4 | 122
Atherosclerosis 4 | 291
Autoimmune lymphoproliferative syndrome 4 | 11
Brain disease 4 | 96
Carcinoma, Hepatocellular 4 | 228
Carcinoma, Renal Cell 4 | 124
Cardiomyopathies 4 | 110
Cell Transformation, Neoplastic 4 | 97
Colonic Neoplasms 4 | 142
Depressive disorder 4 | 409
Eye disease 4 | 62
Heart disease 4 | 306
Hypertension 4 | 396
Juvenile rheumatoid arthritis 4 | 111
Liver Failure, Acute 4 | 29
Liver carcinoma 4 | 240
Melanoma 4 | 711
Multiple Sclerosis 4 | 540
Myocardial Reperfusion Injury 4 | 37
Neoplastic Cell Transformation 4 | 89
Obesity 4 | 678
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Pick disease 4 | 1,894
Pneumonia 4 | 174
Prostatic Neoplasms 4 | 495
Renal Cell Carcinoma 4 | 214
Retinal Detachment 4 | 51
Stomach Neoplasms 4 | 300
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
primitive neuroectodermal tumor 4 | 3,035
spina bifida 4 | 1,074
Mental Depression 3 | 333
active Crohn's disease 3 | 922
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 7 | 4,145
Kinase 6 | 634
Transcription Factor 2 | 1,400

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 33 | 33
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Death domain-containing protein CRADD CRADD Tbio Non-IDG -1.34614 23.0 400
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Caspase-6 CASP6 Tchem Enzyme -2.49135 293.6 874
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.62553 373.2 500
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.66223 525.4 1185