Development Level

Tchem 6 | 1,598
Tclin 6 | 613
Tbio 2 | 11,445

IMPC Phenotype

abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
increased blood urea nitrogen ... 1 | 48
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
preweaning lethality, complete... 1 | 979
thrombocytopenia 1 | 56

Disease

Cancer 12 | 2,499
osteosarcoma 11 | 7,950
Carcinoma 10 | 11,493
lung cancer 9 | 4,740
ovarian cancer 9 | 8,520
medulloblastoma, large-cell 8 | 6,241
glioblastoma 7 | 5,792
Breast cancer 6 | 3,578
invasive ductal carcinoma 6 | 2,951
dermatomyositis 5 | 966
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
psoriasis 5 | 6,694
Anemia 4 | 365
Kidney cancer 4 | 2,613
Mastocytosis 4 | 27
Rheumatoid arthritis 4 | 1,191
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
Adenocarcinoma 3 | 122
Arthritis 3 | 290
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Dermatitis, Allergic Contact 3 | 67
Fatigue 3 | 182
Hypereosinophilic syndrome 3 | 71
Hypoplastic mandible condyle 3 | 275
Immune system cancer 3 | 140
Leukemia 3 | 104
Lymphoid leukemia 3 | 160
Mammary Neoplasms 3 | 425
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Myopia 3 | 176
Pick disease 3 | 1,894
Polycythemia vera 3 | 27
Precancerous Conditions 3 | 80
Primary polycythemia 3 | 8
Schizophrenia 3 | 1,160
Somatic mutation 3 | 61
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
atypical teratoid / rhabdoid tumor 3 | 5,112
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Abortion, Spontaneous 2 | 109
Acquired scoliosis 2 | 281
Allergic hypersensitivity disease 2 | 126
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Congenital Epicanthus 2 | 177
Curvature of spine 2 | 282
DOID:2627 2 | 94
Delayed bone age 2 | 136
Downward slant of palpebral fissure 2 | 158
Endometrial cancer 2 | 311
Failure to gain weight 2 | 365
Fever 2 | 138
Frontal bossing 2 | 157
Hepatomegaly 2 | 285
High forehead 2 | 102
Isolated cases 2 | 72
Joint hyperflexibility 2 | 78
Lung Neoplasms 2 | 232
Malaria 2 | 160
Myocardial Ischemia 2 | 169
Nasal bridge wide 2 | 236
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Prostatic Neoplasms 2 | 495
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Sensorineural Hearing Loss (disorder) 2 | 284
Spontaneous abortion 2 | 113
Tall forehead 2 | 102
Triangular face 2 | 58
Ventricular Septal Defects 2 | 119
Weight decreased 2 | 103
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
periodontitis 2 | 293
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 6 | 12,091
Kinase 5 | 634
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 14 | 14
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-5 IL5 Tclin Non-IDG -3.45852 2701.9 571
Serine/threonine-protein kinase pim-1 PIM1 Tchem Kinase -2.87679 758.8 531
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Cytokine-inducible SH2-containing protein CISH Tbio Non-IDG -2.93418 780.9 119
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484
Interleukin-5 receptor subunit alpha IL5RA Tclin Non-IDG -1.63572 35.8 259
Syntenin-1 SDCBP Tbio Non-IDG -2.35478 226.2 320