Development Level

Tclin 23 | 613
Tbio 22 | 11,445
Tchem 15 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 3 | 278
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
cataract 2 | 92
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 51 | 11,493
Cancer 48 | 2,499
ovarian cancer 41 | 8,520
glioblastoma 36 | 5,792
osteosarcoma 34 | 7,950
Breast cancer 30 | 3,578
lung cancer 30 | 4,740
psoriasis 29 | 6,694
medulloblastoma, large-cell 28 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
invasive ductal carcinoma 23 | 2,951
malignant mesothelioma 23 | 3,232
ependymoma 22 | 4,679
interstitial cystitis 22 | 2,312
Kidney cancer 21 | 2,613
Schizophrenia 21 | 1,160
oligodendroglioma 21 | 2,850
Rheumatoid arthritis 19 | 1,191
diabetes mellitus 19 | 1,728
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 17 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung adenocarcinoma 17 | 2,716
non-small cell lung cancer 17 | 2,890
pancreatic cancer 17 | 2,398
Autosomal recessive predisposition 16 | 1,442
ulcerative colitis 16 | 1,819
Multiple myeloma 15 | 1,332
Short stature 15 | 531
astrocytic glioma 15 | 2,597
breast carcinoma 15 | 1,638
juvenile dermatomyositis 15 | 1,187
Depressive disorder 14 | 409
Intellectual disability 14 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
lung carcinoma 14 | 2,843
pituitary cancer 14 | 1,972
Alzheimer's disease 13 | 658
Blepharoptosis 13 | 231
Breast Neoplasms 13 | 445
Downward slant of palpebral fissure 13 | 158
Hypoplastic mandible condyle 13 | 275
Major Depressive Disorder 13 | 301
Mammary Neoplasms 13 | 425
Mandibular hypoplasia 13 | 275
Melanoma 13 | 711
Micrognathism 13 | 275
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,855
Astrocytoma, Pilocytic 12 | 3,081
Bipolar Disorder 12 | 666
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Pick disease 12 | 1,894
Poor school performance 12 | 645
Seizures 12 | 596
Stomach Neoplasms 12 | 300
Asthma 11 | 385
Byzanthine arch palate 11 | 194
Cryptorchidism 11 | 296
Delayed bone age 11 | 136
Diarrhea 11 | 253
Epilepsy 11 | 792
Mental Depression 11 | 333
Orbital separation excessive 11 | 244
Unipolar Depression 11 | 250
primary pancreatic ductal adenocarcinoma 11 | 1,109
Autistic Disorder 10 | 364
Carcinoma, Hepatocellular 10 | 228
Cerebrovascular disease 10 | 238
Heart disease 10 | 306
Hepatomegaly 10 | 285
High forehead 10 | 102
Kidney disease 10 | 430
Liver Cirrhosis 10 | 181
Liver Cirrhosis, Experimental 10 | 769
Liver carcinoma 10 | 240
Lung Neoplasms 10 | 232
Muscle hypotonia 10 | 571
Neoplasm Metastasis 10 | 168
Neuropathy 10 | 261
Obesity 10 | 678
Pectus excavatum 10 | 100
Prostatic Neoplasms 10 | 495
Renal Cell Carcinoma 10 | 214
Strabismus 10 | 270
Tall forehead 10 | 102
acute quadriplegic myopathy 10 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
tuberculosis 10 | 2,010
Cognitive delay 9 | 608
Endometriosis 9 | 540
Mental and motor retardation 9 | 608
astrocytoma 9 | 1,146
cutaneous lupus erythematosus 9 | 1,057
dermatomyositis 9 | 966

Tissue

Blood and immune system 60 | 16,909
Digestive Tract 60 | 17,369
Female tissues 60 | 17,400
Male tissues 60 | 17,142
Skin and soft tissues 60 | 17,230
Cardiovascular System 59 | 15,192
Endocrine System 59 | 18,159
Liver and Pancreas 59 | 16,750
Nervous System 59 | 16,725
Respiratory system 59 | 16,393
Urinary Tract 59 | 16,678

Target Family

Non-IDG 32 | 12,091
Kinase 20 | 634
Enzyme 7 | 4,145
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
LIM domain transcription factor LMO4 LMO4 Tbio Non-IDG -1.08353 14.5 216