Development Level

Tbio 8 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
short tibia 1 | 97

Disease

Carcinoma 12 | 11,493
osteosarcoma 9 | 7,950
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
atypical teratoid / rhabdoid tumor 7 | 5,112
ovarian cancer 7 | 8,520
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
psoriasis 6 | 6,694
Astrocytoma, Pilocytic 5 | 3,081
Cancer 5 | 2,499
astrocytic glioma 5 | 2,597
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
Substance Withdrawal Syndrome 4 | 55
adult high grade glioma 4 | 3,801
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
Disease Models, Animal 3 | 155
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Neoplasm Invasiveness 3 | 161
Stomach Neoplasms 3 | 300
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
juvenile dermatomyositis 3 | 1,187
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
pediatric high grade glioma 3 | 1,064
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Amnesia 2 | 17
Animal Mammary Neoplasms 2 | 136
Arthritis 2 | 290
Asthma 2 | 385
Bipolar Disorder 2 | 666
Brain Ischemia 2 | 110
CEROID LIPOFUSCINOSIS, NEURONAL, 6 2 | 6
Carcinoma, Squamous Cell 2 | 110
Cardiomyopathies 2 | 110
Cholestasis, Extrahepatic 2 | 25
Clostridium difficile colitis 2 | 12
Cocaine-Related Disorders 2 | 92
Cognitive delay 2 | 608
Crohn's disease 2 | 321
Diabetes Mellitus, Experimental 2 | 108
Female infertility 2 | 30
Gastrointestinal system disease 2 | 54
Gliosis 2 | 56
Global developmental delay 2 | 608
Head and Neck Neoplasms 2 | 26
Heart disease 2 | 306
Hyperalgesia 2 | 83
Hypertrophy 2 | 17
Infertility, Female 2 | 28
Intellectual disability 2 | 1,016
Kidney Neoplasm 2 | 29
Kidney Neoplasms 2 | 37
Kidney disease 2 | 430
Liver Neoplasms, Experimental 2 | 59
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Lymphoma, T-Cell, Cutaneous 2 | 22
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mental Depression 2 | 333
Mental and motor retardation 2 | 608
Neoplasm Metastasis 2 | 168
Nerve Degeneration 2 | 121
Neurodegenerative disease 2 | 414
Ovarian Neoplasms 2 | 102
Pneumonia, Pneumococcal 2 | 6
Radiation Injuries, Experimental 2 | 11
Relapsing remitting multiple sclerosis 2 | 14
Rheumatoid arthritis 2 | 1,191
Sepsis 2 | 24
Sezary Syndrome 2 | 27
Squamous cell carcinoma 2 | 129
Streptococcal pneumonia 2 | 6
Trigeminal Neuralgia 2 | 24
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
gastric cancer 2 | 459
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
ovarian neoplasm 2 | 99
pancreatic cancer 2 | 2,398
primary pancreatic ductal adenocarcinoma 2 | 1,109
Angioimmunoblastic Lymphadenopathy 1 | 4
Epileptic encephalopathy 1 | 26
Immunoblastic Lymphadenopathy 1 | 4
Lymphoma, T-Cell, Peripheral 1 | 9
Round face 1 | 45
Round, full face 1 | 45

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 3 | 4,145
GPCR 2 | 408
Kinase 2 | 634

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 137 | 137
http://pathwaycommons.org/pc2/... 125 | 125
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Sphingosine 1-phosphate receptor 5 S1PR5 Tclin GPCR -1.70131 47.1 273
Guanine nucleotide-binding protein subunit alpha-12 GNA12 Tbio Non-IDG -0.97325 9.11 163
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Sphingosine 1-phosphate receptor 4 S1PR4 Tclin GPCR -1.78966 58.4 256
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.25466 17.2 212
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501