Development Level

Tbio 12 | 11,445
Tclin 6 | 613
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased body length 1 | 32
increased circulating LDL chol... 1 | 13
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 15 | 11,493
Cancer 12 | 2,499
ovarian cancer 11 | 8,520
glioblastoma 10 | 5,792
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
Astrocytoma, Pilocytic 9 | 3,081
atypical teratoid / rhabdoid tumor 9 | 5,112
diabetes mellitus 9 | 1,728
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 8 | 2,890
pituitary cancer 8 | 1,972
Obesity 7 | 678
group 3 medulloblastoma 7 | 4,104
lung cancer 7 | 4,740
oligodendroglioma 7 | 2,850
psoriasis 7 | 6,694
Alzheimer's disease 6 | 658
Epilepsy 6 | 792
Stomach Neoplasms 6 | 300
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
Autosomal recessive predisposition 5 | 1,442
Bipolar Disorder 5 | 666
Bladder Neoplasm 5 | 112
Breast cancer 5 | 3,578
Depressive disorder 5 | 409
Mental Depression 5 | 333
Seizures 5 | 596
Urinary Bladder Neoplasms 5 | 114
adult high grade glioma 5 | 3,801
breast carcinoma 5 | 1,638
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,312
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Acne 4 | 52
Alcoholic Intoxication, Chronic 4 | 289
Breast Neoplasms 4 | 445
Colorectal Neoplasms 4 | 243
Down syndrome 4 | 499
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Mammary Neoplasms 4 | 425
Schizophrenia 4 | 1,160
Short stature 4 | 531
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
lung carcinoma 4 | 2,843
pancreatic cancer 4 | 2,398
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Animal Mammary Neoplasms 3 | 136
Arthritis 3 | 290
Broad forehead 3 | 59
Byzanthine arch palate 3 | 194
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Squamous Cell 3 | 110
Cerebral atrophy 3 | 178
Cerebrovascular disease 3 | 238
Cholangiocarcinoma 3 | 35
Cholestasis 3 | 155
Cognitive delay 3 | 608
Craniosynostosis 3 | 74
Dermatitis 3 | 157
Diarrhea 3 | 253
Dull intelligence 3 | 645
Endometriosis 3 | 540
Eye disease 3 | 62
Fatty liver disease 3 | 103
Global developmental delay 3 | 608
Gout 3 | 106
Heart disease 3 | 306
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Low intelligence 3 | 645
Lung disease 3 | 142
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Osteoporosis 3 | 363
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Renal Cell Carcinoma 3 | 214
Squamous cell carcinoma 3 | 129
Strabismus 3 | 270
Urinary bladder cancer 3 | 36
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074

Tissue

Endocrine System 23 | 18,159
Nervous System 23 | 16,725
Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Female tissues 22 | 17,400
Male tissues 22 | 17,142
Urinary Tract 22 | 16,678
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Cardiovascular System 20 | 15,192
Liver and Pancreas 20 | 16,750

Target Family

Non-IDG 11 | 12,091
Kinase 7 | 634
Enzyme 4 | 4,145
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 23 | 23
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Syndecan-3 SDC3 Tbio Non-IDG -1.86172 78.8 179
Fibroblast growth factor receptor 3 FGFR3 Tclin Kinase -3.00731 1050.1 479
Pleiotrophin PTN Tbio Non-IDG -2.85163 746.7 392
Fibroblast growth factor 23 FGF23 Tbio Non-IDG -3.19500 1726.4 296
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.44255 276.4 502
Peripheral plasma membrane protein CASK CASK Tchem Kinase -2.12241 130.2 227
Melanocortin receptor 4 MC4R Tchem GPCR -2.95116 930.2 251