Development Level

Tbio 38 | 11,445
Tchem 20 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 3 | 298
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal gait 1 | 69
abnormal rib morphology 1 | 10
absent startle reflex 1 | 24
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
enlarged kidney 1 | 14
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
limb grasping 1 | 41
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
tremors 1 | 39

Disease

Carcinoma 49 | 11,493
ovarian cancer 41 | 8,520
glioblastoma 37 | 5,792
Cancer 36 | 2,499
atypical teratoid / rhabdoid tumor 32 | 5,112
osteosarcoma 32 | 7,950
ependymoma 31 | 4,679
psoriasis 30 | 6,694
medulloblastoma, large-cell 29 | 6,241
lung cancer 27 | 4,740
adult high grade glioma 23 | 3,801
Astrocytoma, Pilocytic 22 | 3,081
Breast cancer 22 | 3,578
group 3 medulloblastoma 22 | 4,104
Kidney cancer 21 | 2,613
oligodendroglioma 19 | 2,850
Schizophrenia 17 | 1,160
lung adenocarcinoma 17 | 2,716
primitive neuroectodermal tumor 17 | 3,035
astrocytic glioma 16 | 2,597
malignant mesothelioma 16 | 3,232
astrocytoma 15 | 1,146
invasive ductal carcinoma 15 | 2,951
subependymal giant cell astrocytoma 15 | 2,287
Intellectual disability 14 | 1,016
non-small cell lung cancer 14 | 2,890
Multiple myeloma 13 | 1,332
Pick disease 13 | 1,894
Short stature 13 | 531
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,855
pituitary cancer 13 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
juvenile dermatomyositis 12 | 1,187
Bipolar Disorder 11 | 666
Byzanthine arch palate 11 | 194
Depressive disorder 11 | 409
Muscle hypotonia 11 | 571
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Acquired scoliosis 10 | 281
Blepharoptosis 10 | 231
Carcinoma, Squamous Cell 10 | 110
Curvature of spine 10 | 282
Dull intelligence 10 | 645
Hypoplastic mandible condyle 10 | 275
Joint hyperflexibility 10 | 78
Low intelligence 10 | 645
Mandibular hypoplasia 10 | 275
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Micrognathism 10 | 275
Poor school performance 10 | 645
Stomach Neoplasms 10 | 300
diabetes mellitus 10 | 1,728
Downward slant of palpebral fissure 9 | 158
Noonan syndrome 9 | 34
Orbital separation excessive 9 | 244
Seizures 9 | 596
Squamous cell carcinoma 9 | 129
Strabismus 9 | 270
pancreatic cancer 9 | 2,398
Abnormal dermatoglyphic pattern 8 | 24
Alzheimer's disease 8 | 658
Cryptorchidism 8 | 296
Epilepsy 8 | 792
Nerve Degeneration 8 | 121
Parkinson's disease 8 | 392
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
ulcerative colitis 8 | 1,819
Amyotrophic lateral sclerosis 7 | 451
Aortic coarctation 7 | 30
Cognitive delay 7 | 608
Congenital Epicanthus 7 | 177
Delayed bone age 7 | 136
Endometrial cancer 7 | 311
Failure to gain weight 7 | 365
Frontal bossing 7 | 157
Global developmental delay 7 | 608
High forehead 7 | 102
Melanoma 7 | 711
Mental Depression 7 | 333
Mental and motor retardation 7 | 608
Myopia 7 | 176
Neck webbing 7 | 35
Neoplasm Metastasis 7 | 168
Neurodegenerative disease 7 | 414
Neuropathy 7 | 261
Pectus excavatum 7 | 100
Pediatric failure to thrive 7 | 365
Tall forehead 7 | 102
Toxic encephalopathy 7 | 141
Triangular face 7 | 58
Ventricular Septal Defects 7 | 119
breast carcinoma 7 | 1,638
hepatocellular carcinoma 7 | 547
lung carcinoma 7 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
tuberculosis 7 | 2,010

Tissue

Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 63 | 17,400
Nervous System 63 | 16,725
Skin and soft tissues 63 | 17,230
Blood and immune system 62 | 16,909
Cardiovascular System 62 | 15,192
Male tissues 62 | 17,142
Respiratory system 62 | 16,393
Urinary Tract 62 | 16,678
Liver and Pancreas 61 | 16,750

Target Family

Non-IDG 32 | 12,091
Enzyme 17 | 4,145
Kinase 12 | 634
GPCR 1 | 408
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.98363 12.4 115
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328